The Significance of a Viral Post on Social Media

Social media platforms have quickly become one of the main ways for communication, especially among young adults. These platforms have provided a new field of data of interest to researchers. Popular content on social media is often referred to as “viral,” and can be posted in the format of a “meme” relating to the culture of the platform. Such content is often posted by social media influencers. This exploratory study investigates a particular instance of viral content, using Twitter data. Quantitative analyses were used to determine the frequency of tweets related to the topics of the viral video using hashtags. A content analysis was done to investigate the themes present within the data set. Findings suggest that attitudes and behaviors of Twitter users are influenced by viral video posts. Viral marketing businesses may use these results to improve advertising on social media platforms

Peggy\u27s Favorite : Characteristi Two - Step

https://digitalcommons.library.umaine.edu/mmb-ps/1584/thumbnail.jp

Nature of Deaf Mentoring Dyads: Role of Subjugated Knowledge

Research has indicated that the United States is lagging behind the rest of the world in producing science, technology, engineering, and math (STEM) majors and career professionals. The National Science Foundation has launched one particular initiative to address this need which is centered on underrepresented communities. Matching mentoring dyads based on similar social identities may provide necessary role models (Davidson & Foster-Johnson, 2001) and unlock subjugated knowledge (Collins 2000) about how to be both deaf and scientist. Among their underrepresented counterparts, deaf individuals are disproportionately underrepresented in STEM careers (NSF, 2011). The leakage in the STEM pipeline between undergraduate enrollment and the awarding of doctoral degrees to deaf students may be attributed, in part, to a lack of individuals in academic mentoring roles who are deaf; sharing the same social circumstances and characteristics as these students (Mertens & Hopson, 2006). Understanding the experience of deaf scholars and deaf students engaged in formally mentored undergraduate research efforts is helpful in determining the appropriate long term plans and strategies necessary to promote growth of deaf people entering STEM fields. This phenomenological study captured the experiences of three deaf mentoring dyads operating in undergraduate research laboratories. Informed by the subjugated knowledge framework (Collins, 2000), participants described the nature of their mentoring dyad and the nature and content of subjugated knowledge extended to deaf mentees. This process was identified as central to and helping deaf undergraduates to develop as both deaf individuals and ultimately deaf scientists. This study employed a triangulated data set, including semi-structured individual interviews with deaf mentors and deaf mentees, dyad interviews, and document collection. From data analysis, three themes emerged: (a) The “Psychology Of Deaf Space”, (b), How To Be A Deaf Scientist: Building Navigational Capital, and (c) Deaf Role Models: Transforming Experiences. The findings from this study inform undergraduate faculty and administrators in higher education on the importance of having deaf mentors as a part of the deaf undergraduate students’ success in the STEM arena. This study also offers to hearing mentors and administrators a series of recommendations for supporting deaf students with whom they may be working in isolation. These individuals have many opportunities to support the individual deaf student as the student works to successfully navigates predominantly hearing STEM communities

Work-Related Resilience: Deaf Professionals’ Perspectives

Ten Deaf professionals were interviewed about their perspectives on resilience risk and protective factors that affect career success. Thematic analysis revealed four main risk factors, all related to inequalities: (a) audism and linguistism; (b) networking challenges; (c) working harder than hearing peers; and, (d) promotion limitations. The Deaf community was described as a resilience protective factor that counters the work-related risk factors because it provides: (a) social support; (b) role models; and, (c) “Deaf can” optimism. The results have important implications for vocational rehabilitation, education and counseling programs as they highlight the protective factors Deaf employees need for work-related resilience

University American Sign Language Learners: Longitudinal Self- and Faculty Evaluation Ratings

Students who are Deaf or hard of hearing (D/HH) represent a small yet diverse population of students with individual needs who often receive educational services provided by sign language interpreters and teachers of the Deaf/hard of hearing (D/HH). Many interpreters and teachers appear unprepared to model fluent American Sign Language (ASL) skills when working with D/HH students who use sign language for communication and instruction. We investigated the ASL skills of 19 interpreting and Deaf education candidates within one university preparation program at two points in time: the end of ASL I class (Time 1) and a year later at the end of ASL IV (Time 2). We used video recordings of candidates’ signed renditions of a picture book, a rubric of 12 sign language indicators with five levels of proficiency across each indicator, and ratings conducted independently by the candidates and the five authors. Four of these authors were university professors in two different Deaf education/interpreting preparation programs and the fifth was a teacher at a residential school for the Deaf. Three have typical hearing and use ASL as a secondary language; two are Deaf and use ASL as their primary language. We compared candidates’ self-ratings to those of the five authors. We found that candidates tended to over-estimate their skills at T1; self-ratings and author ratings increased from T1 to T2, and candidates had higher agreement with most authors at T2 compared to T1. In addition, we found differences among ratings between the university faculty and the high school teacher. We discuss these differences in our findings and address implications for evaluating and improving university candidates’ ASL skills

Demographic changes and marker properties affect detection of human population differentiation

<p>Abstract</p> <p>Background</p> <p>Differentiating genetically between populations is valuable for admixture and population stratification detection and in understanding population history. This is easy to achieve for major continental populations, but not for closely related populations. It has been claimed that a large marker panel is necessary to reliably distinguish populations within a continent. We investigated whether empirical genetic differentiation could be accomplished efficiently among three Asian populations (Hmong, Thai, and Chinese) using a small set of highly variable markers (15 tetranucleotide and 17 dinucleotide repeats).</p> <p>Results</p> <p>Hmong could be differentiated from Thai and Chinese based on multi-locus genotypes, but Thai and Chinese were indistinguishable from each other. We found significant evidence for a recent population bottleneck followed by expansion in the Hmong that was not present in the Thai or Chinese. Tetranucleotide repeats were less useful than dinucleotide repeat markers in distinguishing between major continental populations (Asian, European, and African) while both successfully distinguished Hmong from Thai and Chinese.</p> <p>Conclusion</p> <p>Demographic history contributes significantly to robust detection of intracontinental population structure. Populations having experienced a rapid size reduction may be reliably distinguished as a result of a genetic drift -driven redistribution of population allele frequencies. Tetranucleotide markers, which differ from dinucleotide markers in mutation mechanism and rate, are similar in information content to dinucleotide markers in this situation. These factors should be considered when identifying populations suitable for gene mapping studies and when interpreting interpopulation relationships based on microsatellite markers.</p

Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research

<p>Abstract</p> <p>Background</p> <p>GABA transporter-1 (GAT-1; genetic locus <it>SLC6A1</it>) is emerging as a novel target for treatment of neuropsychiatric disorders. To understand how population differences might influence strategies for pharmacogenetic studies, we identified patterns of genetic variation and linkage disequilibrium (LD) in <it>SLC6A1 </it>in five populations representing three continental groups.</p> <p>Results</p> <p>We resequenced 12.4 kb of <it>SLC6A1</it>, including the promoters, exons and flanking intronic regions in African-American, Thai, Hmong, Finnish, and European-American subjects (total n = 40). LD in <it>SLC6A1 </it>was examined by genotyping 16 SNPs in larger samples. Sixty-three variants were identified through resequencing. Common population-specific variants were found in African-Americans, including a novel 21-bp promoter region variable number tandem repeat (VNTR), but no such variants were found in any of the other populations studied. Low levels of LD and the absence of major LD blocks were characteristic of all five populations. African-Americans had the highest genetic diversity. European-Americans and Finns did not differ in genetic diversity or LD patterns. Although the Hmong had the highest level of LD, our results suggest that a strategy based on the use of tag SNPs would not translate to a major improvement in genotyping efficiency.</p> <p>Conclusion</p> <p>Owing to the low level of LD and presence of recombination hotspots, <it>SLC6A1 </it>may be an example of a problematic gene for association and haplotype tagging-based genetic studies. The 21-bp promoter region VNTR polymorphism is a putatively functional candidate allele for studies focusing on variation in GAT-1 function in the African-American population.</p

Identification of population substructure among Jews using STR markers and dependence on reference populations included

Background: Detecting population substructure is a critical issue for association studies of health behaviors and other traits. Whether inherent in the population or an artifact of marker choice, determining aspects of a population's genetic history as potential sources of substructure can aid in design of future genetic studies. Jewish populations, among which association studies are often conducted, have a known history of migrations. As a necessary step in understanding population structure to conduct valid association studies of health behaviors among Israeli Jews, we investigated genetic signatures of this history and quantified substructure to facilitate future investigations of these phenotypes in this population. Results: Using 32 autosomal STR markers and the program STRUCTURE, we differentiated between Ashkenazi (AJ, N = 135) and non-Ashkenazi (NAJ, N = 226) Jewish populations in the form of Northern and Southern geographic genetic components (AJ north 73%, south 23%, NAJ north 33%, south 60%). The ability to detect substructure within these closely related populations using a small STR panel was contingent on including additional samples representing major continental populations in the analyses. Conclusions: Although clustering programs such as STRUCTURE are designed to assign proportions of ancestry to individuals without reference population information, when Jewish samples were analyzed in the absence of proxy parental populations, substructure within Jews was not detected. Generally, for samples with a given grandparental country of birth, STRUCTURE assignment values to Northern, Southern, African and Asian clusters agreed with mitochondrial DNA and Y-chromosomal data from previous studies as well as historical records of migration and intermarriage

NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults

Background : Neuropeptide Y (NPY) has been found to be anxiolytic in animals and humans. A recent study found NPY expression to be inversely correlated with trait anxiety. We examined whether rs16147, a functional single nucleotide polymorphism in the promoter region of NPY, moderated the relationship between hurricane exposure and risk for generalized anxiety disorder (GAD) in an epidemiologic sample of adults living in areas affected by the 2004 Florida Hurricanes. Methods : Data from this study comes from 616 adults from the 2004 Florida Hurricanes study who returned buccal DNA samples via mail. Selection of participants occurred via random digit-dial procedures. Participants were interviewed via telephone about hurricane exposure and posthurricane GAD symptoms. The outcome measure was DSM-IV GAD diagnosis, assessed via structured interview. Results : Rs16147 in NPY was associated with increased risk of GAD diagnosis under conditions of high hurricane exposure (P<.01). This gene by environment interaction remained significant after adjustment for sex, ancestry (as determined by Bayesian clustering of genotypes), and age. Conclusions : NPY rs16147 modifies risk of postdisaster GAD under conditions of high stressor (hurricane) exposure. This is the first demonstration of gene–environment interaction for this locus. Depression and Anxiety, 2010. © 2009 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69171/1/20648_ftp.pd

Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α

Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B and TNF) coding for these two cytokines. Prior to induction, TNF exhibited pre-bound TATA Binding Protein (TBP) and paused RNA Polymerase II (Pol II), hallmarks of poised immediate-early (IE) genes. In contrast, unstimulated IL1B displayed very low levels of both TBP and paused Pol II, requiring the lineage-specific Spi-1/PU.1 (Spi1) transcription factor as an anchor for induction-dependent interaction with two TLR-activated transcription factors, C/EBPβ and NF-κB. Activation and DNA binding of these two pre-expressed factors resulted in de novo recruitment of TBP and Pol II to IL1B in concert with a permissive state for elongation mediated by the recruitment of elongation factor P-TEFb. This Spi1-dependent mechanism for IL1B transcription, which is unique for a rapidly-induced/poised IE gene, was more dependent upon P-TEFb than was the case for the TNF gene. Furthermore, the dependence on phosphoinositide 3-kinase for P-TEFb recruitment to IL1B paralleled a greater sensitivity to the metabolic state of the cell and a lower sensitivity to the phenomenon of endotoxin tolerance than was evident for TNF. Such differences in induction mechanisms argue against the prevailing paradigm that all IE genes possess paused Pol II and may further delineate the specific roles played by each of these rapidly expressed immune modulators. © 2013 Adamik et al