Having a people : beyond individualism and essentialism in resistance to interlocked oppressions.

This dissertation draws on the Aristotelian and contemporary communitarian belief that humans are socially constituted, and analyzes the manifestations of this belief in contemporary identity politics and in the concept of \u27culture\u27 that often underlies identity politics. While I argue that it is important to maintain a communitarian conception of the self, I depart from Aristotle and the communitarian tradition by rejecting the assumption that a constitutive community is characterized by unity and homogeneity. I then claim that identity politics has inherited both the virtues and the problems of communitarian theory. Just as communitarians claim that the self is never free from social constitution, so identity politics have taken the self\u27s identity to be formed along lines of socially defined group differences, and like communitarianism, some identity politics has entailed a call for unity. In the case of identity politics, the requirement for membership in the community may be sharing certain essential characteristics of identity; difference can result in marginalization, forced assimilation to the group norm, or expulsion. Because identity politics often relies upon the concept of \u27culture\u27 to ground group identities, I also examine this concept. When a community\u27s unity derives from its members understanding themselves to share a culture, the maintenance of the culture itself can be conservatizing; the culture can remain closed off from changes as it preserves the traditional or authentic ; furthermore, it can come to be treated as an object outside of the people who live it and as such the changing lived realities of these people--particularly changes that cross lines of identity--do not serve to continually offer new, changing, and ambiguous ways of conceiving of what is shared between members of the community. I argue for the development of group identity that recognizes intersecting group differences, and can permit hybridity or mixed identities. I end by suggesting that for a constitutive community to remain truly constitutive without harming its members through marginalization, forced assimilation to a norm or a shared essence, or stagnation, members must give up the sort of control that maintains the community as a unity

Moral Failure — Response to Critics

I briefly introduce Moral Failure as a book that brings together philosophical and empirical work in moral psychology to examine moral requirements that are non-negotiable and that contravene the principle that “ought implies can.” I respond to Rivera by arguing that the process of construction that imbues normative requirements with authority need not systematize or eliminate conflicts between normative requirements. My response to Schwartzman clarifies what is problematic about nonideal theorizing that limits itself to offering action-guidance. In response to Kittay, I defend my rejection of “ought implies can,” and consider the implications of the concept of unfair moral requirements

Product sieving challenges in TFF perfusion cell culture

Integrated continuous biomanufacturing has gained significant interest because of its potential to streamline production by integrating upstream and downstream processes. Combined with an intensified perfusion bioreactor, continuous processing can greatly reduce cost, space requirements, and handling steps, while improving production efficiency.1,2 During perfusion operation, product and spent media are removed while cells are retained within the bioreactor with a cell separation device. In particular hollow fiber membranes, attached externally to the bioreactor, permit tangential or alternating flow filtration (TFF, ATF), as cells are recirculated through the unit and permeate is harvested for downstream processing.3,4 However, membrane fouling and issues with product sieving, especially associated with a TFF setup, have a direct impact on total product yield from the process, and can cause hollow fiber reliability issues which in some cases can result in premature termination of a bioreactor run. It is hypothesized that membrane fouling from host cell proteins, cell debris, or additives such as antifoam can result in decreased product sieving as product transmission through the membrane decreases over time.5,6 Toward addressing issues with product sieving, we aim to identify the underlying causes of membrane fouling, associated with host cell proteins and antifoam, and to develop new methods to lengthen their lifetime during perfusion operation. This presentation will focus on some tools and experiments that we have conducted to address this issue with the goal to identify factors within the bioreactor that lead to reduced product sieving and implementation of new strategies to mitigate the effects of these factors during operation. 1. Konstantinov, K.B., Cooney C.L “White Paper on Continuous Bioprocessing” Journal of Pharmaceutical Sciences 104 (3), 2015, 813-820. 2. Warikoo, V., et al. “Integrated Continuous Production of Recombinant Therapeutic Proteins” Biotechnology and Bioengineering 109 (12), 2012, 3018-3029. 3. Clinke, M.F., et al. “Very High Density of CHO Cells in Perfusion by ATF or TFF in WAVE Bioreactor. Part I.” Biotechnology Progress 29 (3), 2013, 754-767. 4. Karst, D.J., et al. “Characterization and Comparison of ATF and TFF in Stirred Bioreactors for Continuous Mammalian Cell Culture Processes” Biochemical Engineering Journal 110, 2016, 17-26. 5. Van Reis, R., Zydney, A. “Bioprocess Membrane Technology” Journal of Membrane Science 297, 2007, 16-50. 6. Wang, S., et al. “Shear Contributions to Cell Culture Performance and Product Recovery in ATF and TFF Perfusion Systems” Journal of Biotechnology 246, 2017, 52-60

Expecting Bad Luck

This paper draws on Claudia Card’s discussions of moral luck to consider the complicated moral life of people—described as pessimists—who accept the heavy knowledge of the predictability of the bad moral luck of oppression. The potential threat to ethics posed by this knowledge can be overcome by the pessimist whose resistance to oppression, even in the absence of hope, expresses a sense of still having a ‘‘claim’’ on flourishing despite its unattainability under oppression

Identifying High Quality Youth Programs: Information for High School Youth Professionals

4 pp.This is a series of 6 fact sheets related to identifying high quality youth programs from several perspectives: middle/high school youth, parents, youth development professionals and identifying resources in the community. It also includes a check list that will be included with each of the fact sheets

Identifying High Quality Youth Programs: Information for Parents

4 pp.This is a series of 6 fact sheets related to identifying high quality youth programs from several perspectives: middle/high school youth, parents, youth development professionals and identifying resources in the community. It also includes a check list that will be included with each of the fact sheets

Identifying High Quality Youth Programs: Information for Youth Development Professionals

4 pp.This is a series of 6 fact sheets related to identifying high quality youth programs from several perspectives: middle/high school youth, parents, youth development professionals and identifying resources in the community. It also includes a check list that will be included with each of the fact sheets