Neuroblastoma: The Clinical Aspects

Neuroblastoma is a predominantly pediatric cancer, arising from the primordial neural crest cells that form the sympathetic nervous system. The prognosis for patients with neuroblastoma can vary from uniform survival in low risk patients to fatality in patients with high risk disease. This chapter gives a brief overview of the epidemiology, genetics, clinical presentation, diagnosis, and discussion of the various staging systems and risk classifications of neuroblastoma. We also briefly describe our understanding of the conventional and novel treatment modalities available and their effects on the current prognosis of patients with neuroblastoma. The purpose of this chapter is to serve as a brief overview of the clinical aspects of neuroblastoma, to serve as a foundation of knowledge for scientists aspiring to develop new therapeutic modalities for this dreadful pediatric disease

Routledge Handbook of Southeast Asian Development

This Handbook traces the uneven experiences that have accompanied development in Southeast Asia. The region is often considered to be a development success story; however, it is increasingly recognized that growth underpinning this development has been accompanied by patterns of inequality, violence, environmental degradation and cultural loss. In 30 chapters, written by established and emerging experts of the region, the Handbook examines development encounters through four thematic sections: • Approaching Southeast Asian development, • Institutions and economies of development, • People and development and • Environment and development. The authors draw from national or sub-national case studies to consider regional scale processes of development – tracing the uneven distribution of costs, risks and benefits. Core themes include the ongoing neoliberalization of development, issues of social and environmental justice and questions of agency and empowerment. This important reference work provides rich insights into the diverse impacts of current patterns of development and in doing so raises questions and challenges for realizing more equitable alternatives. It will be of value to students and scholars of Asian Studies, Development Studies, Human Geography, Political Ecology and Asian Politics

Hoping for a better tomorrow’: a qualitative study of stressors, informal social support and parental coping in a Direct Provision centre in the West of Ireland

This paper focuses on informal social support and coping amongst parents living in a Direct Provision (DP) reception centre in the rural west of Ireland. Since 2000, asylum seekers in Ireland are subject to DP where the state provides accommodation and food to asylum seeking families, and a small supplementary allowance. Despite calls for its abandonment and that it constitutes ‘citizenship based discrimination’, DP features prominently in Irish policy on asylum seeking. Drawing on qualitative interview materials from an evaluation of childcare services in one asylum seeker reception centre, we argue that children living in DP are frequently exposed to risky behaviours, and that the DP system adversely affects children’s resilience, stifling their educational, emotional and social development. In Ireland, supports for families and children living in DP are relatively weak, and despite protests for enhancing asylum seekers’ rights in housing and employment, asylum seekers interviewed for this study feel abandoned by the state. Instead, they rely heavily on local services for emotional and financial supports to cope with living conditions in DP. The paper argues for a culturally responsive approach to policy-making that is grounded in human rights and family support which recognizes the importance of community services in providing emotional and practical supports to parents

Outcomes for permanence and stability for children in long-term care in Ireland

This article is based on research about children in long-term care. It focuses on the factors that help and hinder a child being and feeling stable in their foster home and having a sense of permanence. The research was carried out with children in care inGalway and Donegal between 2008 and 2013. It was proposed by Tusla – Child and Family Agency and carried out by the National University of Ireland, Galway (NUI Galway)UNESCO Child and Family Research Centre (UCFRC). The main factors that were found to influence permanence and stability were relationships, communication, support and continuity. The research shows that it is not only the connection between the child and the foster family or parent that matters. Instead, the whole system surrounding the child must also be taken into account. A model was developed from the research which showed that children in care often have a more complicated system than other children, as it includes both the family of origin and the foster family. This research has been used to inform and improve practice in the children-in-care teams in Galway and Donegal. In particular, this article outlines resources available to foster families in terms of training, services and support

Can We Retain the Economy-Wide Benefits of Energy Efficiency While Reducing the Energy Rebound?

Economy-wide rebound is often presented as a necessary ‘evil’ accompanying economic expansion triggered by energy efficiency improvements. We challenge this position in two, inter-related ways. First, we question the emphasis on potential technical energy savings and losses due to rebound in energy efficiency policy evaluation. This abstracts from the wider economic and societal impacts of energy efficiency improvements that are often positive and valuable to policy makers. Second, we propose that economic expansion and economy-wide rebound need not be highly correlated. We argue that energy efficiency actions targeted at improving the competitiveness of less energy-intensive means of providing services, such as heat and transport, may provide opportunities to boost economic activity while minimising rebound effects. This perspective involves a change in current policy and research thinking, particularly in terms of the type of substitution possibilities that we should focus on in enhancing energy efficiency, economic expansion and rebound relations

Decarbonising domestic heating : the need for policy to help consumers respond to the benefits of technological progress change in electricity supply?

The UK Government’s acceptance of the Committee on Climate Change (CCC) advice on moving to a net zero carbon economy by 2050 makes the need to decarbonise how we heat our homes of even more pressing and strategic importance. Whatever the mix of solutions that is ultimately adopted, increased electrification of our energy system and economy is inevitable

Can the composition of energy use in an expanding economy be altered by consumers' responses to technological change?

Technological change is necessary for economies to grow and develop. This paper investigates how this technological change could be directed in order to simultaneously reduce carbon-intensive energy use and deliver a range of economic benefits. Using both partial and general equilibrium modelling we consider improvements in the efficiency in the delivery of electricity as an increasingly low carbon option in the UK. We demonstrate how linking this to policy action to assist and encourage households to substitute away from more carbon-intensive gas- to electricity-powered heating systems may change the composition of energy use, and implied emissions intensity, but not the level of the resulting economic expansion

Infrared study of the eta Chamaeleontis cluster and the longevity of circumstellar discs

We have analyzed JHKL observations of the stellar population of the ~9 Myr-old eta Chamaeleontis cluster. Using infrared (IR) colour-colour and colour-excess diagrams, we find the fraction of stellar systems with near-IR excess emission is 0.60 pm 0.13 (2_sigma). This results implies considerably longer disc lifetimes than found in some recent studies of other young stellar clusters. For the classical T Tauri (CTT) and weak-lined T Tauri (WTT) star population, we also find a strong correlation between the IR excess and H_alpha emission. The IR excesses of these stars indicate a wide range of star-disc activity; from a CTT star showing high levels of accretion, to CTT - WTT transition objects with evidence for some on-going accretion, and WTT stars with weak or absent IR excesses. Of the 15 known cluster members, 4 stars with IR excesses delta(K-L) > 0.4 mag are likely experiencing on-going accretion owing to strong or variable optical emission. The resulting accretion fraction (0.27 pm 0.13; 2_sigma) shows that the accretion phase, in addition to the discs themselves, can endure for at least ~10 Myr.Comment: 7 pages, 4 figures, accepted for MNRA

Effects of a 12-Week Aerobic Spin Intervention on Resting State Networks in Previously Sedentary Older Adults

Objective: We have previously demonstrated that aerobic exercise improves upper extremity motor function concurrent with changes in motor cortical activity using task-based functional magnetic resonance imaging (fMRI). However, it is currently unknown how a 12-week aerobic exercise intervention affects resting-state functional connectivity (rsFC) in motor networks. Previous work has shown that over a 6-month or 1-year exercise intervention, older individuals show increased resting state connectivity of the default mode network and the sensorimotor network (Voss et al., 2010b; Flodin et al., 2017). However, the effects of shorter-term 12-week exercise interventions on functional connectivity have received less attention.Method: Thirty-seven sedentary right-handed older adults were randomized to either a 12-week aerobic, spin cycling exercise group or a 12-week balance-toning exercise group. Resting state functional magnetic resonance images were acquired in sessions PRE/POST interventions. We applied seed-based correlation analysis to left and right primary motor cortices (L-M1 and R-M1) and anterior default mode network (aDMN) to test changes in rsFC between groups after the intervention. In addition, we performed a regression analysis predicting connectivity changes PRE/POST intervention across all participants as a function of time spent in aerobic training zone regardless of group assignment.Results: Seeding from L-M1, we found that participants in the cycling group had a greater PRE/POST change in rsFC in aDMN as compared to the balance group. When accounting for time in aerobic HR zone, we found increased heart rate workload was positively associated with increased change of rsFC between motor networks and aDMN. Interestingly, L-M1 to aDMN connectivity changes were also related to motor behavior changes in both groups. Respective of M1 laterality, comparisons of all participants from PRE to POST showed a reduction in the extent of bilateral M1 connectivity after the interventions with increased connectivity in dominant M1.Conclusion: A 12-week physical activity intervention can change rsFC between primary motor regions and default mode network areas, which may be associated with improved motor performance. The decrease in connectivity between L-M1 and R-M1 post-intervention may represent a functional consolidation to the dominant M1.Topic Areas: Neuroimaging, Aging

Observational Evidence of For-Profit Delivery and Inferior Nursing Home Care: When Is There Enough Evidence for Policy Change?

This research was financially supported by the Social Sciences and Humanities Research Council