235 research outputs found

    A Generalized Recurrent Neural Architecture for Text Classification with Multi-Task Learning

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    Multi-task learning leverages potential correlations among related tasks to extract common features and yield performance gains. However, most previous works only consider simple or weak interactions, thereby failing to model complex correlations among three or more tasks. In this paper, we propose a multi-task learning architecture with four types of recurrent neural layers to fuse information across multiple related tasks. The architecture is structurally flexible and considers various interactions among tasks, which can be regarded as a generalized case of many previous works. Extensive experiments on five benchmark datasets for text classification show that our model can significantly improve performances of related tasks with additional information from others

    A Study of Coordinated Vehicle Traction Control System Based on Optimal Slip Ratio Algorithm

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    Under complicated situations, such as the low slippery road surface and split-μ road surface, traction control system is the key issue to improve the performance of vehicle acceleration and stability. In this paper, a novel control strategy with engine controller and active pressure controller is presented. First and foremost, an ideal vehicle model is proposed for simulation; then a method for the calculation of optimal slip ratio is also brought. Finally, the scheme of control method with engine controller and active brake controller is presented. From the results of simulation and road tests, it can be concluded that the acceleration performance and stability of a vehicle equipped with traction control system (TCS) can be improved

    Minimization of the environmental impact in the chrome tanning process by a closed-loop recycling technology

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    Content: It is acknowledged that conventional chrome tanning in leather processing discharges significant amounts of chromium, dissolved solids and chlorides. The recycling technology is one of the effective solutions to reduce the environmental impact of chrome tanning waste water at source. In this work, a novel closed recycling technology of chrome tanning wastewater was applied in the tanning process of the goat skins at a pilot scale level. The properties of chrome tanning liquors obtained by the recycling technology and the resultant crust were analyzed. The results show that this close recycling process works well. The contents of Cr2O3, total organic carbon, ammonia nitrogen and chloride ion in the waste water tend to accumulate with the increase of recycling times, and finally reach a balance after 5 times of recycling. The obtained leather sample is full, soft and having a shrinkage temperature comparable to that of conventional chrome tanned leather. SEM images indicate that the resulting leather samples by this recycling technology show fine and clean grain and well-dispersed fibrils. TG and DSC results show that the thermal stability of wet blue leathers tanned by the circular process are similar to those tanned by conventional chrome tanning process. Compared with conventional chrome tanning technology, water, salt and chrome tanning agent are saved in this process, and the zero emission of chrome tanning wastewater is realized. The cleaner production technology exhibits promising application prospect for its economic and environmental benefits. Take-Away: 1. A novel closed recycling technology of chrome tanning wastewater was applied in the tanning process of the goat skins at a pilot scale level. 2. The chrome tanning liquors obtained by the recycling technology and the resultant crust were analyzed. 3. Water, Sodium chloride and chrome tanning agent are saved by the closed recycling technology, and the zero emission of chrome tanning wastewater is realized

    3,3′-Dimethyl-1,1′-methyl­ene­diimidazolium dibromide

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    In the crystal structure of the title compound, C9H14N4 2+·2Br−, the cation and anions have crystallographic mirror symmetry, with the mirror plane running through the central CH2 group for the cation. The latter are stacked along the a axis, forming channels hosting the bromide anions. The crystal packing is stabilized by C—H⋯Br hydrogen-bonding inter­actions, generating a two-dimensional network

    ЭКСПЕРИМЕНТАЛЬНОЕ ИЗУЧЕНИЕ ТЕПЛОВЫХ И ДЕФОРМАЦИОННЫХ ПОЛЕЙ В ПРОЦЕССЕ РАЗРУШЕНИЯ ЭШЕЛОНИРОВАННЫХ РАЗЛОМОВ И ИЗМЕНЕНИЯ ГЕОЛОГИЧЕСКИХ УСЛОВИЙ

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    The article presents results of experimental studies using a bi-axial servo-control system to apply load on samples with extensional and compressional en echelon faults. During the experiments, variations of temperature and thermal images were recorded synchronously by a multi-path contact-type thermometric apparatus and a thermal image system, respectively. A digital CCD camera was employed to synchronously collect images of specimens’ surfaces. The digital speckle correlation method (DSCM) was utilized to analyze the images and to define displacements and strain fields. Our experimental results show that temperature fields have clear responses to opposite stress states in the jog areas of both types of the en echelon faults. Prior to failure of the jog area, its temperature is the highest at the compressional en echelon faults and the lowest at the extensional en echelon faults. Records by DSCM give evidence that mean strain of the jog area is the highest at compressional en echelon faults and the lowest at the extensional en echelon faults. It is revealed that deformation of the en echelon faults occurs in two stages, developing from stress build-up and fault propagation in the jog area to unstable sliding along the fault. Correspondingly, the mechanism of heating-up converts from strain heating into friction heating. During the period of transformation of the temperature rising mechanism, three events are observed in the jog area and its vicinity. Analyses of our experimental results demonstrate that variations of temperatures in the jog area can be indicative of fault sliding and suggest sliding directions. Observations and studies of temperature changes during transformation of the temperature rising mechanism at sensitive portions of faults are of great importance for early detection of precursors of unstable slip on active faults.В статье представлены результаты экспериментального изучения эшелонированных разломов растяжения и сжатия с приложением нагрузки к двуосной автоматически регулируемой модели. В ходе эксперимента производились синхронные замеры температур и тепловых сигналов. Для этого были использованы, соответственно, многоканальный термометрический прибор контактного типа и система регистрации тепловых сигналов. Синхронные снимки поверхностей экспериментальных образцов были получены при помощи цифровой видеокамеры на основе устройства с зарядовой связью. Был применен цифровой метод спекл-корреляции (DSCM) для анализа снимков и определения смещений и деформационных полей. Была установлена очевидная реакция тепловых полей на состояния напряжения противоположных типов в зонах сочленения эшелонированных разломов обоих типов. Перед полным разрушением зоны сочленения самые высокие значения температуры зарегистрированы на эшелонированных разломах сжатия, самые низкие – на эшелонированных разломах растяжения. С помощью метода DSCM самые высокие значения среднего напряжения в зоне сочленения дислокаций зарегистрированы на эшелонированных разломах сжатия, самые низкие – на эшелонированных разломах растяжения. В процессе деформирования эшелонированных разломов выявлены две стадии, развивающиеся от накопления напряжений и прорастания разлома в зону сочленения дислокаций до неустойчивого скольжения по разлому. Соответственно трансформируется механизм нагревания – с нагревания напряжением до нагревания трением. В самой зоне сочленения дислокаций и поблизости от неё в процессе трансформирования механизма повышения температуры наблюдались три фазы. Анализ полученных нами экспериментальных данных показал, что вариации температуры в зоне сочленения дислокации могут указывать на смещения по разлому и позволяют предположить направление смещения. Наблюдение за изменениями температуры и их изучение в процессе трансформирования механизма повышения температуры на чувствительных отрезках разломов имеют большое значение в плане раннего выявления предвестников неустойчивого смещения по активным разломам

    BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells

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    <p>Abstract</p> <p>Background</p> <p>The role of B Lymphocyte Stimulator (BLyS) in the survival of malignant B cells and the maintenance of normal B cell development and homeostasis has been intensively studied in the literature. However, the influence of BLyS on breast cancer progression remains unclear. The study aimed to investigate the effect of hypoxia on BLyS regulation, cell migratory response to BLyS and the possible molecular mechanisms.</p> <p>Methods</p> <p>In this study, we examined the role of BLyS in the migration of human breast cancer cells by transwell assay. We also explored whether BLyS and its receptors expressed in human breast cancer cell lines by immunofluorescence and Western Blotting. Then we detected the expression level of BLyS in both normoxic and hypoxic conditions by real time-PCR and Western Blotting. Pathways involved were confirmed by Western Blotting, immunofluorescence, transwell assay and luciferase assay.</p> <p>Results</p> <p>According to our study, the expression level of BlyS was increased in human breast cancer cell lines in hypoxic conditions. Up-regulation of this protein led to activation and nuclear translocation of NF-kappa B p65. We also found that the number of migrated cells was increased in the presence of BLyS and inhibition of phosphorylation of Akt attenuated the enhanced migratory response.</p> <p>Conclusions</p> <p>It suggested that better understanding of BLyS, an immunopotentiator, may offer a potential therapeutic target for the treatment of human breast cancers. In addition, BLyS promoted breast cancer cells migration, underscoring the necessity of appropriate applications of immunopotentiators to cancer treatment.</p
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