2,575 research outputs found
Book Review: Common Sense and the Fifth Amendment
For years Professor Hook has waged a public love-affair with the Goddess of Reason. Rival suitors, humbly aware that she does not always requite their passion, may be forgiven when they wonder on what evidence Professor Hook lays exclusive claim to her favors, and by what commission he has annointed himself High Priest of her temple. In recent utterances on political subjects, he has invoked the Goddess ritually against the massed attacking hordes of ritualistic liberals. It almost seems as though he spent the greater part of his time belaying his allies because they get in the way of the blows that he might otherwise strike at their common enemies.
At the start of this slender though repetitious volume, Professor Hook has disarmed criticism and propitiated the Goddess by using common sense in the title; by dedicating the work to the memory of Morris Raphael Cohen; by informing his readers that his position expresses a common-sense truth which can be overlooked only by \u27a trained incapacity,\u27 to use Veblen\u27s phrase, to see the obvious in a search for the historically recondite ; and by proclaiming his standpoint as that of unreconstructed liberalism which recognizes the primacy of morality to law, and the centrality of intelligence in morality.... Experience has shown that those who, no matter in what cause, are foes of intelligence are the foes of freedom, too. It turns out that the main target of the book is that old archfoe of intelligence, Dean Erwin N. Griswold of the Harvard Law School, who wrote a booklet on The Fifth Amendment Today and later dared to take issue with Professor Hook in a polemic in the New Leader
The Soviet View of International Law
In the first part of our time this morning, then, I should like to take you rapidly through the development of Soviet international law in its historical setting, describe some salient features of contempoÂrary Soviet international law, dwell at some length upon the soÂ-called principles of peaceful coexistence, and hazard some specuÂlation on the future
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Exotic herbaceous species interact with severe drought to alter soil N cycling in a semi-arid shrubland
Mediterranean-type ecosystems are increasingly threatened by climate change and exotic annual species, jeopardizing the native communities and their global biodiversity. In these systems, soil nitrogen (N) limits net primary production, and its availability can be influenced by both of these stressors. To understand the interactive effects of droughts and exotic herbaceous species on soil N, we monitored the temporal variability of soil inorganic N, net N mineralization, net nitrification, and NO3- leaching under native- and exotic-dominated stands exposed to rainfall manipulation plots in a Mediterranean-type shrub-dominated community. Increasing drought severity resulted in the accumulation of soil NH4+ and NO3-, with a more pronounced increase in exotic-dominated plots. Increased net N mineralization and net nitrification and reduced leaching losses were observed as mechanisms of inorganic N accumulation. In comparison to soils under native plants, soils under exotic plants had enhanced leaching losses upon soil rewetting. We propose that distinct traits of exotic annual herbaceous species associated with higher N inputs, faster turnover, and reduced temporal uptake determine the changes in N cycling in response to droughts. Severe droughts and exotic plants may produce a larger, more vulnerable pool of N that is prone to losses while providing a competitive advantage to promote exotic growth in these N-limited ecosystems
Geometries and energetics of methanol–ethanol clusters: a VUV laser/time-of-flight mass spectrometry and density functional theory study
Hydrogen-bonded clusters, formed above liquid methanol (Me) and ethanol (Et) mixtures of various compositions, were entrained in a supersonic jet and probed using 118 nm vacuum ultraviolet (VUV) laser single-photon ionization/time-of-flight mass spectrometry. The spectra are dominated by protonated cluster ions, formed by ionizing hydrogen-bonded MemEtn neutrals, m = 0–4, n = 0–3, and m + n = 2–5. The structures and energetics of the neutral and ionic species were investigated using both the all-atom optimized potential for liquid state, OPLS-AA, and the density functional (DFT) calculations. The energetic factors affecting the observed cluster distributions were examined. Calculations indicate that the large change in binding energy going from trimer to tetramer can be attributed more to pair-wise interactions than to cooperativity effects
Synchronization of Micromechanical Oscillators Using Light
Synchronization, the emergence of spontaneous order in coupled systems, is of
fundamental importance in both physical and biological systems. We demonstrate
the synchronization of two dissimilar silicon nitride micromechanical
oscillators, that are spaced apart by a few hundred nanometers and are coupled
through optical radiation field. The tunability of the optical coupling between
the oscillators enables one to externally control the dynamics and switch
between coupled and individual oscillation states. These results pave a path
towards reconfigurable massive synchronized oscillator networks
High-Performance Silicon-Based Multiple Wavelength Source
We demonstrate a stable CMOS-compatible on-chip multiple-wavelength source by
filtering and modulating individual lines from a frequency comb generated by a
microring resonator optical parametric oscillator.. We show comb operation in a
low-noise state that is stable and usable for many hours. Bit-error rate
measurements demonstrate negligible power penalty from six independent
frequencies when compared to a tunable diode laser baseline. Open eye diagrams
confirm the fidelity of the 10 Gb/s data transmitted at the comb frequencies
and the suitability of this device for use as a fully integrated silicon-based
WDM source.Comment: 3 pages, 3 figure
Single-inhaler fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol plus umeclidinium using two inhalers for chronic obstructive pulmonary disease: A randomized non-inferiority study
Background: Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patients with chronic obstructive pulmonary disease (COPD). We evaluated the non-inferiority of single-inhaler FF/UMEC/VI versus FF/VI + UMEC using two inhalers.
Methods: Eligible patients with COPD (aged ≥40 years; ≥1 moderate/severe exacerbation in the 12 months before screening) were randomized (1:1; stratified by the number of long-acting bronchodilators [0, 1 or 2] per day during run-in) to receive 24-week FF/UMEC/VI 100/62.5/25 μg and placebo or FF/VI 100/25 μg + UMEC 62.5 μg; all treatments/placebo were delivered using the ELLIPTA inhaler once-daily in the morning. Primary endpoint: change from baseline in trough forced expiratory volume in 1 s (FEV1) at Week 24. The non-inferiority margin for the lower 95% confidence limit was set at − 50 mL.
Results: A total of 1055 patients (844 [80%] of whom were enrolled on combination maintenance therapy) were randomized to receive FF/UMEC/VI (n = 527) or FF/VI + UMEC (n = 528). Mean change from baseline in trough FEV1 at Week 24 was 113 mL (95% CI 91, 135) for FF/UMEC/VI and 95 mL (95% CI 72, 117) for FF/VI + UMEC; the between-treatment difference of 18 mL (95% CI -13, 50) confirmed FF/UMEC/VI’s was considered non-inferior to FF/ VI + UMEC. At Week 24, the proportion of responders based on St George’s Respiratory Questionnaire Total score was 50% (FF/UMEC/VI) and 51% (FF/VI + UMEC); the proportion of responders based on the Transitional Dyspnea Index focal score was similar (56% both groups). A similar proportion of patients experienced a moderate/severe exacerbation in the FF/UMEC/VI (24%) and FF/VI + UMEC (27%) groups; the hazard ratio for time to first moderate/ severe exacerbation with FF/UMEC/VI versus FF/VI + UMEC was 0.87 (95% CI 0.68, 1.12). The incidence of adverse events was comparable in both groups (48%); the incidence of serious adverse events was 10% (FF/UMEC/VI) and 11% (FF/VI + UMEC).
Conclusions: Single-inhaler triple therapy (FF/UMEC/VI) is non-inferior to two inhalers (FF/VI + UMEC) on trough FEV1 change from baseline at 24 weeks. Results were similar on all other measures of efficacy, health-related quality of life, and safety.
Trial registration: GSK study CTT200812; ClinicalTrials.gov NCT02729051 (submitted 31 March 2016)
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