Targeted drug delivery for the treatment of blood cancers

Blood cancers are a type of liquid tumor which means cancer is present in the body fluid. Multiple myeloma, leukemia, and lymphoma are the three common types of blood cancers. Chemotherapy is the major therapy of blood cancers by systemic administration of anticancer agents into the blood. However, a high incidence of relapse often happens, due to the low efficiency of the anticancer agents that accumulate in the tumor site, and therefore lead to a low survival rate of patients. This indicates an urgent need for a targeted drug delivery system to improve the safety and efficacy of therapeutics for blood cancers. In this review, we describe the current targeting strategies for blood cancers and recently investigated and approved drug delivery system formulations for blood cancers. In addition, we also discuss current challenges in the application of drug delivery systems for treating blood cancers

Mechanical, economic, and environmental assessment of recycling reclaimed asphalt rubber pavement using different rejuvenation schemes

Asphalt rubber (AR) is a prevailing sustainable paving material, but the recycling of reclaimed asphalt rubber pavement (RARP) faces the lack of proper rejuvenation strategies and the uncertainties in its economic and environmental values. To fill these gaps, this study assesses the comprehensive performance of RARP-included mixtures using different rejuvenation schemes through mechanical tests, life cycle cost analysis (LCCA), and life cycle assessment. The addition of rejuvenators increased the rutting depth of RARP mixture but their effects on the cracking resistance varied from different types of rejuvenators. The supplement of swollen rubber content was more effective in improving the cracking and aging resistances. Recycling 40 % of RARP into new AR mixture can save 24.5 % of greenhouse gas (GHG) emissions and 35 % of cost within the geographic scope of Hong Kong. The use of rejuvenator increased the GHG emission and cost, while incorporating extra rubber could further reduce the cost

Survey on Factuality in Large Language Models: Knowledge, Retrieval and Domain-Specificity

This survey addresses the crucial issue of factuality in Large Language Models (LLMs). As LLMs find applications across diverse domains, the reliability and accuracy of their outputs become vital. We define the Factuality Issue as the probability of LLMs to produce content inconsistent with established facts. We first delve into the implications of these inaccuracies, highlighting the potential consequences and challenges posed by factual errors in LLM outputs. Subsequently, we analyze the mechanisms through which LLMs store and process facts, seeking the primary causes of factual errors. Our discussion then transitions to methodologies for evaluating LLM factuality, emphasizing key metrics, benchmarks, and studies. We further explore strategies for enhancing LLM factuality, including approaches tailored for specific domains. We focus two primary LLM configurations standalone LLMs and Retrieval-Augmented LLMs that utilizes external data, we detail their unique challenges and potential enhancements. Our survey offers a structured guide for researchers aiming to fortify the factual reliability of LLMs.Comment: 62 pages; 300+ reference

Shewanella Phage Encoding a Putative Anti-crispr-Like Gene Represents a Novel Potential Viral Family

Shewanella is a prevalent bacterial genus in deep-sea environments including marine sediments, exhibiting diverse metabolic capabilities that indicate its significant contributions to the marine biogeochemical cycles. However, only a few Shewanella phages were isolated and deposited in the NCBI database. In this study, we report the isolation and characterization of a novel Shewanella phage, vB_SbaS_Y11, that infects Shewanella KR11 and was isolated from the sewage in Qingdao, China. Transmission electron microscopy revealed that vB_SbaS_Y11 has an icosahedral head and a long tail. The genome of vB_SbaS_Y11 is a linear, double-stranded DNA with a length of 62,799 bp and a G+C content of 46.9%, encoding 71 putative open reading frames. No tRNA genes or integrase-related feature genes were identified. An uncharacterized anti-CRISPR AcrVA2 gene was detected in its genome. Phylogenetic analysis based on the amino acid sequences of whole genomes and comparative genomic analyses indicate that vB_SbaS_Y11 has a novel genomic architecture and shares low similarity to Pseudomonas virus H66 and Pseudomonas phage F116. vB_SbaS_Y11 represents a potential new family-level virus cluster with eight metagenomic assembled viral genomes named Ranviridae. IMPORTANCE The Gram-negative Shewanella bacterial genus currently includes about 80 species of mostly aquatic Gammaproteobacteria, which were isolated around the globe in a multitude of environments, such as freshwater, seawater, coastal sediments, and the deepest trenches. Here, we present a Shewanella phage vB_SbaS_Y11 that contains an uncharacterized anti-CRISPR AcrVA2 gene and belongs to a potential virus family, Ranviridae. This study will enhance the knowledge about the genome, diversity, taxonomic classification, and global distribution of Shewanella phage populations

Targeted Drug Delivery for the Treatment of Blood Cancers

Blood cancers are a type of liquid tumor which means cancer is present in the body fluid. Multiple myeloma, leukemia, and lymphoma are the three common types of blood cancers. Chemotherapy is the major therapy of blood cancers by systemic administration of anticancer agents into the blood. However, a high incidence of relapse often happens, due to the low efficiency of the anticancer agents that accumulate in the tumor site, and therefore lead to a low survival rate of patients. This indicates an urgent need for a targeted drug delivery system to improve the safety and efficacy of therapeutics for blood cancers. In this review, we describe the current targeting strategies for blood cancers and recently investigated and approved drug delivery system formulations for blood cancers. In addition, we also discuss current challenges in the application of drug delivery systems for treating blood cancers

Financing and pricing strategies of construction supply chain under capital constraint

Affected by factors such as cost, the financial constraints faced by the supply chain are becoming more and more severe. This paper constructs a financing and pricing decision-making model for the construction supply chain under capital constraints, and uses Stackelberg game theory to analyze and obtain the best financing and pricing strategy for the construction supply chain under the internal and external financing modes. The study found that when centralized decision-making is adopted, there is a profit distribution model that makes the profits obtained by construction developers and contractors greater than the profits obtained in decentralized decision-making; the internal financing model of the construction supply chain is better than external financing, and can enable the construction supply chain get higher profits

Complete chloroplast genome sequence of tropical orchid Renanthera imschootiana

Renanthera imschootiana Rolfe is an epiphyte of genus Renanthera in family Orchidaceae. R. imschootiana is a rare tropical orchid with high ornamental value. We determined its complete chloroplast genome sequence to better understand its relationship with other Orchidaceae species. The chloroplast genome of R. imschootiana has a length of 143,836 bp, which comprises a large single copy region of 83,356 bp, a small single copy region of 11,172 bp, and a pair of reverse repeat regions of 24,654 bp each. Its genome has a total GC content of 36.8% and contains 127 genes, including 82 protein-coding genes, 37 tRNA genes, and 8 rRNA genes. Maximum likelihood phylogenetic analysis showed that R. imschootiana is closely related to Vanda brunnea, Holcoglossum flavescens, and H. amesianum

Effects of tillage management on cbbL-carrying bacteria and soil organic carbon dynamics across aggregate size classes in the farmland of North China Plain

Calvin-Benson-Bassham cycle (cbbL)-carrying bacteria in soil are essential to renew and circulate organic matter. However, the relation between cbbL-carrying bacteria and soil carbon dynamics under tillage managements, especially across the aggregate size remains unclear. Thus, in our study, soil organic carbon (SOC) storages, mineralization, and the cbbL-carrying bacterial community across five soil aggregate sizes were thoroughly investigated under four tillage treatments: conventional rotary tillage (CT), deep plowing (DP), subsoiling (SS), no-tillage (NT). We found macroaggregates (>2 mm) contributed most with regard to SOC stocks, whereas microaggregates (1 mm) with the highest cumulative SOC mineralization were found in subsoiling, whereas microaggregates had the lowest cumulative mineralization under no-tillage. By physically protecting, no-tillage specifically inhibited carbon dioxide (CO2) emissions in macroaggregates (>1 mm), whereas increased SOC levels and encouraged CO2 releases across microaggregates. Shifts in the co-occurrence network demonstrated that subsoiling promoted the joint symbiotic function between cbbL-carrying bacteria, the efficiency of matter and energy, and information transfer. And the keystone species, the enhanced cooperation and stochastic processes of autotrophic microorganisms under subsoiling lead to increased carbon fixation and reduced CO2 emissions in microaggregates with limited oxygen and nutrients. Overall, our work verified physical protection of large aggregates under no-tillage and improvement of microbial interaction efficiency under subsoiling. This may offer a theoretical foundation for the choice of tillage practices in fluvo-aquic soil regions