Improving ot Impeding? The Local & National Effects of State & Federal Regulation

The law surrounding our three focus areas — equine, agriculture, and natural resources — uniquely impacts the Kentucky economy. And regulations, at all levels, have two often competing goals that policymakers must balance: economic growth with human and environmental protection. Please join our discussion as legal scholars, practitioners, and regulators share their thoughts on the benefits and limits of regulations

Book Reviews

Book Reviews: the Water of Life, a Jungian Journey Through Hawaiian Myth by Rita Knipe; Before the Horror: the Population of Hawai'i on the Eve of Western Contact by David E. Stannard; Observations and Interpretation of Hawaiian Volcanism and Seismicity 1779-1955. An Annotated Bibliography and Subject Index by Thomas L. Wright and Taeko Jane Takahashi; An Account of Two Voyages to the South Seas, to Australia, New Zealand, Oceania 1826-1829 in the Corvette Astrolabe; and to the Straits of Magellan, Chile, Oceania, Southeast Asia, Australia, Antarctica, New Zealand, and the Torres Strait 1837-1840 in the Corvettes Astrolabe and Zelee. by Jules S. C. Dumont d'Urville, Translated and edited by Helen Rosenman; Paths of Duty: American Missionary Wives in Nineteenth-Century Hawaii by Patricia Grimshaw; Journal of Stephen Reynolds Edited by Pauline King; Moramona: the Mormons in Hawaii by R. Lanier Britsch; the Peopling of Hawai'i by Eleanor C. Nordyk

Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques

Several HIV-1 and SIV vaccine candidates have shown partial protection against viral challenges in rhesus macaques. However, the protective efficacy of vaccine-elicited polyclonal antibodies has not previously been demonstrated in adoptive transfer studies in nonhuman primates. In this study, we show that passive transfer of purified antibodies from vaccinated macaques can protect naive animals against SIVmac251 challenges. We vaccinated 30 rhesus macaques with Ad26-SIV Env/Gag/Pol and SIV Env gp140 protein vaccines and assessed the induction of antibody responses and a putative protective signature. This signature included multiple antibody functions and correlated with upregulation of interferon pathways in vaccinated animals. Adoptive transfer of purified immunoglobulin G (IgG) from the vaccinated animals with the most robust protective signatures provided partial protection against SIVmac251 challenges in naive recipient rhesus macaques. These data demonstrate the protective efficacy of purified vaccine-elicited antiviral antibodies in this model, even in the absence of virus neutralization.National Institutes of Health (Grants AI060354, AI080289, AI102660, AI124377, AI126603, AI128751, AI129797, OD024917