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Permission to print the published articles (paper I and II) is granted from the copyright holders. Permission to figure 1 from copyright © holder Johan Thorfinn, from Linköping University Medical Dissertation No.950 Cover illustration © CMA microdialysis, Stockholm, Sweden. Adapted to cover and text b

Perioperative Myocardial Damage Cardiac Outcome in Patients-at-Risk undergoing Non-Cardiac Surgery

Despite increasingly sophisticated perioperative management, cardiovascular complications continue to be major challenges for the clinician. As a growing number of elderly patients with known coronary artery disease (CAD) or with risk factors for CAD are undergoing noncardiac surgery, cardiovascular complications will remain a significant clinical problem in the future. The overall objective of this thesis was to study the incidence of myocardial damage and perioperative adverse cardiac events, to determine predictors of poor outcome and to assess the effect of a medical intervention in patients at risk undergoing non-cardiac surgery. The studies in this thesis were conducted on a total of 952 patients undergoing non-cardiac surgery. Studies I and IV were multicenter studies; whereas the patients included in studies II and III underwent non-cardiac surgery at Linkoping University Hospital, Sweden. The correlation between postoperative myocardial damage and short- and long-term outcome were studied in 546 patients, aged 70 years or older undergoing non-cardiac surgery of at least 30 minutes duration. This study showed a close correlation between postoperative myocardial damage and poor short- as well as long-term outcome. Elevated Troponin T was a stron

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Cover: Ilustration of the tumor microenvironment in pancreatic cancer. Cover picture and all ilustrations included in the thesis was performed by Rada Chakarov