Quantum interference in nested d-wave superconductors: a real-space perspective

We study the local density of states around potential scatterers in d-wave superconductors, and show that quantum interference between impurity states is not negligible for experimentally relevant impurity concentrations. The two impurity model is used as a paradigm to understand these effects analytically and in interpreting numerical solutions of the Bogoliubov-de Gennes equations on fully disordered systems. We focus primarily on the globally particle-hole symmetric model which has been the subject of considerable controversy, and give evidence that a zero-energy delta function exists in the DOS. The anomalous spectral weight at zero energy is seen to arise from resonant impurity states belonging to a particular sublattice, exactly as in the 2-impurity version of this model. We discuss the implications of these findings for realistic models of the cuprates.Comment: 12 pages, 10 figs, submitted to Phys. Rev.

Two impurities in a d-wave superconductor:local density of states

We study the problem of two local potential scatterers in a d-wave superconductor, and show how quasiparticle bound state wave functions interfere. Each single-impurity electron and hole resonance energy is in general split in the presence of a second impurity into two, corresponding to one even parity and one odd parity state. We calculate the local density of states (LDOS), and argue that scanning tunneling microscopy (STM) measurements should be capable of extracting information about the Green's function in the pure system by a systematic study of 2-impurity configurations. In some configurations highly localized, long-lived states are predicted. We discuss the effects of realistic band structures, and how 2-impurity STM measurements could help distinguish between current explanations of LDOS impurity spectra in the BSCCO-2212 system.Comment: 16 pages,21 figure,New Version to be Published on P.R.

Quantum interference in dirty d-wave superconductors

The local differential tunneling conductance on a Zn impurity in a disordered d-wave superconductors is studied. Quantum interference between many impurities leads to definitive quasiparticle spectra. We suggest that an elaborate analysis on impurity-induced spectra with quantum interference effect included may be able to pin down the sign and strength of the scattering potential of a Zn impurity in low density limit. Numerical simulations calculated with appropriately determined impurity parameters are in satisfactory agreement with the observations from scanning tunneling microscopy (STM) experiments even in subtle details

Power spectrum of many impurities in a d-wave superconductor

Recently the structure of the measured local density of states power spectrum of a small area of the \BSCCO (BSCCO) surface has been interpreted in terms of peaks at an "octet" of scattering wave vectors determined assuming weak, noninterfering scattering centers. Using analytical arguments and numerical solutions of the Bogoliubov-de Gennes equations, we discuss how the interference between many impurities in a d-wave superconductor alters this scenario. We propose that the peaks observed in the power spectrum are not the features identified in the simpler analyses, but rather "background" structures which disperse along with the octet vectors. We further consider how our results constrain the form of the actual disorder potential found in this material.Comment: 5 pages.2 figure

Activation of P2X7-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice

<p>Abstract</p> <p>Background</p> <p>The study tested the hypothesis that apoptosis can prevent and control growth of neoplastic cells. Previous studies in-vitro have shown that the pro-apoptotic P2X₇receptor regulates growth of epithelial cells. The specific objective of the present study was to understand to what degree the P2X₇system controls development and growth of skin cancer in vivo, and what cellular and molecular mechanisms are involved in the P2X₇action.</p> <p>Methods</p> <p>Skin neoplasias in mice (papillomas, followed by squamous spindle-cell carcinomas) were induced by local application of DMBA/TPA. Experiments in-vitro utilized cultured epidermal keratinocytes generated from wild-type or from P2X₇-null mice. Assays involved protein immunostaining and Western blots; mRNA real-time qPCR; and apoptosis (evaluated in situ by TUNEL and quantified in cultured keratinocytes as solubilized DNA or by ELISA). Changes in cytosolic calcium or in ethidium bromide influx (P2X₇pore formation) were determined by confocal laser microscopy.</p> <p>Results</p> <p>(a) Co-application on the skin of the P2X₇specific agonist BzATP inhibited formation of DMBA/TPA-induced skin papillomas and carcinomas. At the completion of study (week 28) the proportion of living animals with cancers in the DMBA/TPA group was 100% compared to 43% in the DMBA/TPA+BzATP group. (b) In the normal skin BzATP affected mainly P2X₇-receptor – expressing proliferating keratinocytes, where it augmented apoptosis without evoking inflammatory changes. (c) In BzATP-treated mice the degree of apoptosis was lesser in cancer than in normal or papilloma keratinocytes. (d) Levels of P2X₇receptor, protein and mRNA were 4–5 fold lower in cancer tissues than in normal mouse tissues. (e) In cultured mouse keratinocytes BzATP induced apoptosis, formation of pores in the plasma membrane, and facilitated prolonged calcium influx. (f) The BzATP-induced apoptosis, pore-formation and augmented calcium influx had similar dose-dependence for BzATP. (g) Pore formation and the augmented calcium influx were depended on the expression of the P2X₇receptor, while the BzATP-induced apoptosis depended on calcium influx. (h) The BzATP-induced apoptosis could be blocked by co-treatment with inhibitors of caspase-9 and caspase-3, but not of caspase-8.</p> <p>Conclusion</p> <p>(a) P2X₇-dependent apoptosis is an important mechanism that controls the development and progression of epidermal neoplasia in the mouse. (b) The P2X₇-dependent apoptosis is mediated by calcium influx via P2X₇pores, and involves the caspase-9 (mitochondrial) pathway. (c) The diminished pro-apoptotic effect of BzATP in mouse cancer keratinocytes is possibly the result of low expression of the P2X₇receptor. (d) Activation of P2X₇-dependent apoptosis, e.g. with BzATP could be a novel chemotherapeutic growth-preventive modality for papillomas and epithelial cancers in vivo.</p

Local Stereo Matching Using Adaptive Cross-Region-Based Guided Image Filtering with Orthogonal Weights

Adaptive cross-region-based guided image filtering (ACR-GIF) is a commonly used cost aggregation method. However, the weights of points in the adaptive cross-region (ACR) are generally not considered, which affects the accuracy of disparity results. In this study, we propose an improved cost aggregation method to address this issue. First, the orthogonal weight is proposed according to the structural feature of the ACR, and then the orthogonal weight of each point in the ACR is computed. Second, the matching cost volume is filtered using ACR-GIF with orthogonal weights (ACR-GIF-OW). In order to reduce the computing time of the proposed method, an efficient weighted aggregation computing method based on orthogonal weights is proposed. Additionally, by combining ACR-GIF-OW with our recently proposed matching cost computation method and disparity refinement method, a local stereo matching algorithm is proposed as well. The results of Middlebury evaluation platform show that, compared with ACR-GIF, the proposed cost aggregation method can significantly improve the disparity accuracy with less additional time overhead, and the performance of the proposed stereo matching algorithm outperforms other state-of-the-art local and nonlocal algorithms

High-Temperature Cracking of Pentene to Ethylene and Propylene over H-ZSM-5 Zeolites: Effect of Reaction Conditions and Mechanistic Insights

The effects of reaction conditions on the yield of ethylene and propylene from pentene cracking were investigated in a fixed-bed reactor at 500–750 °C and for a weight hourly space velocity (WHSV) of 15–83 h−1. The total yield of ethylene and propylene reached a maximum (67.8 wt%) at 700 °C and 57 h−1. In order to explore the reaction mechanism at high temperatures, a thermal/catalytic cracking proportion model was established. It was found that the proportion of pentene feed chemically adsorbed with the acid sites and cracked through catalytic cracking was above 88.4%, even at 750 °C. Ethylene and propylene in the products were mainly derived from catalytic cracking rather than thermal cracking at 650–750 °C. In addition, the suitable reaction network for pentene catalytic cracking was deduced and estimated. The results showed that the monomolecular cracking proportion increased from 1% at 500 °C to 95% at 750 °C. The high selectivity of ethylene and propylene at high temperatures was mainly due to the intensification of the monomolecular cracking reaction. After 20 times of regeneration, the acidity and pore structure of the zeolite had hardly changed, and the conversion of pentene remained above 80% at 650 °C

A Novel Graphic-Aided Algorithm (gNIPT) Improves the Accuracy of Noninvasive Prenatal Testing

Noninvasive Prenatal Testing (NIPT) has advanced the detection of fetal chromosomal aneuploidy by analyzing cell-free DNA in peripheral maternal blood. The statistic Z-test that it utilizes, which measures the deviation of each chromosome dosage from its negative control, is now widely accepted in clinical practice. However, when a chromosome has loss and gain regions which offset each other in the z-score calculation, merely using the Z-test for the result tends to be erroneous. To improve the performance of NIPT in this aspect, a novel graphic-aided algorithm (gNIPT) that requires no extra experiment procedures is reported in this study. In addition to the Z-test, this method provides a detailed analysis of each chromosome by dividing each chromosome into multiple 2 Mb size windows, calculating the z-score and copy number variation of each window, and visualizing the z-scores for each chromosome in a line chart. Data from 13537 singleton pregnancy women were analyzed and compared using both the normal NIPT (nNIPT) analysis and the gNIPT method. The gNIPT method had significantly improved the overall positive predictive value (PPV) of nNIPT (88.14% vs. 68.00%, p=0.0041) and the PPV for trisomy 21 (T21) detection (93.02% vs. 71.43%, p=0.0037). There were no significant differences between gNIPT and nNIPT in PPV for trisomy 18 (T18) detection (88.89% vs. 63.64%, p=0.1974) and in PPV for trisomy 13 (T13) detection (57.14% vs. 50.00%, p=0.8004). One false-negative T18 case in nNIPT was detected by gNIPT, which demonstrates the potency of gNIPT in discerning chromosomes that have variation in multiple regions with an offsetting effect in z-score calculation. The gNIPT was also able to detect copy number variation (CNV) in chromosomes, and one case with pathogenic CNV was detected during the study. With no additional test requirement, gNIPT presents a reasonable solution in improving the accuracy of normal NIPT

A simple and scalable method for preparing low-defect ZIF-8 tubular membranes

Substrate modification by an ultrathin ZnO layer followed by surface activation promotes homogeneous surface nucleation and the growth of a low-defect ZIF-8 tubular membrane that exhibits superb gas permeation and permselectivity