Study on Resistance Switching Properties of Na0.5Bi0.5TiO3Thin Films Using Impedance Spectroscopy

The Na0.5Bi0.5TiO3(NBT) thin films sandwiched between Au electrodes and fluorine-doped tin oxide (FTO) conducting glass were deposited using a sol–gel method. Based on electrochemical workstation measurements, reproducible resistance switching characteristics and negative differential resistances were obtained at room temperature. A local impedance spectroscopy measurement of Au/NBT was performed to reveal the interface-related electrical characteristics. The DC-bias-dependent impedance spectra suggested the occurrence of charge and mass transfer at the interface of the Au/NBT/FTO device. It was proposed that the first and the second ionization of oxygen vacancies are responsible for the conduction in the low- and high-resistance states, respectively. The experimental results showed high potential for nonvolatile memory applications in NBT thin films

Erchen Decoction Ameliorates Lipid Metabolism by the Regulation of the Protein CAV-1 and the Receptors VLDLR, LDLR, ABCA1, and SRB1 in a High-Fat Diet Rat Model

Lipid metabolism disorder is a common metabolic disorder characterized by abnormal lipid levels in blood. Erchen decoction (ECD) is a traditional Chinese medicine prescription, which is used for the treatment of diseases caused by retention of phlegm dampness. It has been reported to ameliorate the disorder of lipid metabolism. The aim of the present study was to investigate the effects and underlying mechanisms of ECD in lipid metabolism disorder induced by a high-fat diet (HFD) in rats. ECD (4.35g/kg/d) and atorvastatin (10mg/kg/d, positive control) were orally administered to HFD-fed rats for four weeks. The parameters, food, water consumption, body weight, body length, liver, and visceral fat weight and the content of serum lipids and lipid transporters were assessed. The effects of ECD on the mRNA and protein expression levels of lipid transport factors were measured by real-time PCR and western blotting. The present study demonstrated that ECD improved the disorders of serum lipid and lipid transporters in HFD-fed rats, TG (0.70±0.08 mmol/L, p0.05). Concomitantly, ECD reversed the abnormal expressions of those lipid transport factors in the liver and visceral fat

Chaihu-Shugan-San administration ameliorates perimenopausal anxiety and depression in rats.

Chaihu-Shugan-San (CSS) is a traditional Chinese herbal formula that is widely used for treating perimenopausal symptoms in China; however, its mechanisms remain unknown. The present study was designed to investigate potential CSS mechanisms in rats with unpredicted chronic mild stress (UCMS) and normally aging rats (52 weeks of age). We performed the sucrose consumption test along with the forced swimming test to confirm depression-like behavior and the open field test (OFT) to confirm anxiety-like behavior in the animals. In addition, we used an enzyme-linked immunosorbent assay to measure serum and hippocampal estradiol (E2) levels and a quantitative real-time polymerase chain reaction to assess hippocampal mRNA levels of estrogen receptors (ERs) α and β as well as G protein-coupled receptor 30 (GPR30). We found that CSS administration resulted in a significant increase in the ratio of hippocampal ERα and ERβ mRNA (ERα/ERβ ratio) in UCMS rats (p<0.001). However, no significant changes were observed in E2 levels, ERα mRNA expression, and GPR30 mRNA expression. In contrast, changes in ERα/ERβ mRNA ratio were sensitively associated with changes in mood states in the animal models. These findings suggest that enhancement of ERα/ERβ ratio may play a role in the pharmacological mechanisms of CSS. Furthermore, this ratio can be employed as a potential index for evaluating mood states in animal models and can be considered as a therapeutic target for perimenopausal anxiety and depression in the future

Nitrogen Application Can Optimize Form of Selenium in Soil in Selenium-Rich Areas to Affect Selenium Absorption and Accumulation in Black Wheat

The composition and form of selenium in the soil have significant effects on the selenium content of crops. In this study, we investigated the selenium absorption pathway in plants by studying the interaction between nitrogen fertilizer and soil selenium. Our results showed that the selenium concentration enrichment factors (CEF) varied within the same region due to nitrogen fertilizer application, where they ranged from 1.33 to 5.02. The soil selenium flow coefficient (mobility factor, MF) increased with higher nitrogen application rates. The sum of the MF values for each soil layer treated with nitrogen application rates of 192 kg hm−2 and 240 kg hm−2 was 0.70, which was 64% higher than that for the control group with no nitrogen application. In the 0–20 cm soil layer, the highest summed water-soluble and exchangeable selenium and relative percentage of total selenium (12.45%) was observed at a nitrogen application rate of 240 kg hm−2. In the 20–40 cm soil layer, the highest relative percentage content of water-soluble and exchangeable selenium and total selenium (12.66%) was observed at a nitrogen application rate of 192 kg hm−2. Experimental treatment of black wheat with various concentrations of sodium selenite showed that selenium treatment at 50 μmol L−1 significantly increased the reduced glutathione (GSH) levels in the leaves and roots of seedlings, where the GSH contents increased by 155.4% in the leaves and by 91.5% in the roots. Further analysis of the soil–black wheat system showed that nitrogen application in selenium-rich areas affected the soil selenium flow coefficient and morphological composition, thereby changing the enrichment coefficient for leaves (0.823), transport capacity from leaves to grains (–0.530), and enrichment coefficient for roots (0.38). These changes ultimately affected the selenium concentration in the grains of black wheat

Nutrient Cycling and Nitrogen Management Impact of Sowing Method and Soil Water Consumption on Yield Nitrogen Utilization in Dryland Wheat (<i>Triticum aestivum</i> L.)

The current study was designed to investigate the best sowing method that encourages dry matter accumulation to increase dryland wheat yield, grain quality, and protein content. Three different seeding methods were applied: (I) wide-space sowing (WSS), (II) furrow sowing, and (III) drill sowing. Two nitrogen levels, namely low nitrogen (N1) and high nitrogen (N2), were also applied, and the pure nitrogen was 150 kg ha−1 and 210 kg ha−1, respectively. Wide-space sowing significantly increased the ears and yield production, the maximum, and average grain-filling rate while furrow sowing delayed the disappearance of the population after anthesis, increased the duration of grain filling, and then significantly increased the number of spikes and the 1000-grain weight increased, respectively. Drill sowing compared to wide-space sowing significantly increased the content of nitrogen in the grain of the nitrogen harvest index, and it increased the content of protein and the yield of protein, respectively. In addition, the grain yield and protein yield of wide-precision sowing were significantly higher than that of trench sowing. Our findings suggest that wide-space sowing was beneficial for increasing water consumption during the growth period, increasing the tiller dynamics, improving the plant dry matter quality, and increasing the grain protein

Serum and Hippocampal E₂ levels.

<p>The results for serum (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0072428#pone-0072428-g005" target="_blank">Figure 5A</a>.) and hippocampal (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0072428#pone-0072428-g005" target="_blank">Figure 5B</a>.) E₂ levels were analogous. The E₂ levels in the CON group were significantly higher than those in the other groups (<i>p</i><0.001), but no difference was observed among the other groups. Values are means ± SEM. **<i>p</i><0.001. The <i>p</i>-value was established by analysis of variance (ANOVA). The post-hoc Bonferroni test was not applied when the <i>p</i>-value was >0.05 as per ANOVA).</p