Niedertemperaturdiffusion von Siliziumverunreinigungen

In der Arbeit werden die Versuchsergebnisse der Verfasser zur Niedertemperaturdiffusion der Nebengruppenelemente I (Au, Ag), VI (Cr) und VII (Ni, pd) des Periodensystems in Si verallgemeinert dargestellt. Die Problemstellung ergab sich aus der Bedeutung, die die Niedertemperaturdiffusion in der neuen Technologie der Festphasenepitaxie des Siliziums spielt, aber auch aufgrund der Erscheinungen, die die physikalische Zuverlässigkeit der elektronischen Bauteile bestimmen

EFFECT OF RITUXIMAB ON THE BLOOD CHOLESTEROL TRANSPORT SYSTEM IN PATIENTSWITH RHEUMATOID ARTHRITIS

Objective: To study the time course of changes in the indices of the blood lipid spectrum in patients with rheumatoid arthritis (RA) treated with rituximab during a 24-week follow-up. Subjects and methods. The study enrolled 39 patients (36 females and 3 males) with a valid diagnosis of RA; their mean age was 50 years; disease duration 93.5 months; duration activity scale (DAS) 6.1 scores. A previous ineffective treatment with methotrexate was found in 6 patients; that with two basic anti-inflammatory drugs or more in 30, and previous TNF- inhibitor therapy failed in 14 of the 39 patients. The blood lipid spectrum and intima-media thickness (IMT) were determined before and 24 weeks after the first injection of rituximab. The drug was intravenously administered dropwise in a dose of 1000 mg twice at a 14-week interval. Therapeutic efficiency was estimated according to the RA activity index - DAS28. All the patients showed a satisfactory/good response to rituximab therapy. Results. There was a double reduction in the frequency of hypoalfalipoproteinemia and in the increased atherogenicity index (AI). Elevated cholesterol (CH), triglycerides (TG), and low-density lipoprotein (LDL CH) levels were found in equal frequencies before and 24 week after rituximab administration. There was a 5% rise in CH concentrations, a considerable (22%) increase in high-density lipoprotein CH, and an 18.6% decrease in AI (

Erratum to: Sedimentary Basins of the East Siberian Sea and the Chukchi Sea and the Adjacent Area of the Amerasia Basin: Seismic Stratigraphy and Stages of Geological History (Geotectonics, (2019), 53, 6, (635-657), 10.1134/S0016852119060104)

The article “Sedimentary Basins of the East Siberian Sea and the Chukchi Sea and the Adjacent Area of the Amerasia Basin: Seismic Stratigraphy and Stages of Geological History”, written by A. M. Nikishin, K. F. Startseva, V. E. Verzhbitsky, S. Cloetingh, N. A.Malyshev, E. I. Petrov, H. Posamentier, S. I. Freiman, M. D. Lineva, and N. N. Zhukov, was originally published electronically in SpringerLink on 31 January 2020 without Open Access. After publication in volume 53, issue 6, pages 635–657 the authors decided to make the article an Open Access publication. Therefore, the copyright of the article has been changed t

Sedimentary Basins of the East Siberian Sea and the Chukchi Sea and the Adjacent Area of the Amerasia Basin: Seismic Stratigraphy and Stages of Geological History

Abstract: The seismic stratigraphy scheme for the shelf basins of the East Siberian Sea and the Chukchi Sea region and the adjacent deepwater area of the Amerasia basin has been developed, and mega-sequences (or tectonostratigraphic units) with the conventional ages of 125‒100, 100‒80, 80‒66, 66‒56, 46‒45, 45‒34, 34‒20, 20‒0 Ma are distinguished. Zhokhov foredeep basin of the Late Jurassic‒Neocomian age is distinguished between the New Siberia and the De Long islands. Three main phases of rifting are identified on the shelves in the region with ages of 125–100, 66–56, and 45–37 Ma. The main phase of continental rifting occurred in the Podvodnikov and Toll basins at 125‒100 Ma. The typical clinoform accumulation of sediments occurred at the edge of the shelf at 66–20 Ma. We identified three syntectonic epochs of the formation of clinoform sequences with the ages of 66–45, 45–34, and 34–20 Ma. The phase of uplifting and compression in the region of Wrangel Island happened at ≈66 Ma. The relatively monotonous tectonic setting with approximately the same thicknesses of the sedimentary cover began at 20 Ma

Sedimentary Basins of the East Siberian Sea and the Chukchi Sea and the Adjacent Area of the Amerasia Basin: Seismic Stratigraphy and Stages of Geological History

Abstract: The seismic stratigraphy scheme for the shelf basins of the East Siberian Sea and the Chukchi Sea region and the adjacent deepwater area of the Amerasia basin has been developed, and mega-sequences (or tectonostratigraphic units) with the conventional ages of 125‒100, 100‒80, 80‒66, 66‒56, 46‒45, 45‒34, 34‒20, 20‒0 Ma are distinguished. Zhokhov foredeep basin of the Late Jurassic‒Neocomian age is distinguished between the New Siberia and the De Long islands. Three main phases of rifting are identified on the shelves in the region with ages of 125–100, 66–56, and 45–37 Ma. The main phase of continental rifting occurred in the Podvodnikov and Toll basins at 125‒100 Ma. The typical clinoform accumulation of sediments occurred at the edge of the shelf at 66–20 Ma. We identified three syntectonic epochs of the formation of clinoform sequences with the ages of 66–45, 45–34, and 34–20 Ma. The phase of uplifting and compression in the region of Wrangel Island happened at ≈66 Ma. The relatively monotonous tectonic setting with approximately the same thicknesses of the sedimentary cover began at 20 Ma

Erratum to: Sedimentary Basins of the East Siberian Sea and the Chukchi Sea and the Adjacent Area of the Amerasia Basin: Seismic Stratigraphy and Stages of Geological History (Geotectonics, (2019), 53, 6, (635-657), 10.1134/S0016852119060104)

The article “Sedimentary Basins of the East Siberian Sea and the Chukchi Sea and the Adjacent Area of the Amerasia Basin: Seismic Stratigraphy and Stages of Geological History”, written by A. M. Nikishin, K. F. Startseva, V. E. Verzhbitsky, S. Cloetingh, N. A.Malyshev, E. I. Petrov, H. Posamentier, S. I. Freiman, M. D. Lineva, and N. N. Zhukov, was originally published electronically in SpringerLink on 31 January 2020 without Open Access. After publication in volume 53, issue 6, pages 635–657 the authors decided to make the article an Open Access publication. Therefore, the copyright of the article has been changed t

ROLE OF MULTIPLEX CYTOKINE ANALYSIS IN THE EVALUATION OF THE EFFICACY OF RITUXIMAB DURING TREATMENT FOR RHEUMATOID ARTHRITIS

Along with its basic activity in removing B-lymphocytes, rituximab (RTM) causes depletion of a population of CD20+ T cells that can pro- duce a variety of immunoregulatory and proinflammatory cytokines and chemokines. Objective: to define a role of multiplex cytokine analysis in the evaluation of the efficiency of using RMT in rheumatoid arthritis (RA). Subjects and methods. Thirty-four patients with the valid diagnosis of RA according to the ACR criteria of 1987 were examined. The con- centrations of cytokines were measured using the xMAP technology (27-plex). Results and discussion. In the group of patients with a clinical response to therapy with the gene engineering biological agent, there was a decrease in the concentrations of interleukins (IL) 1β, 1ra, 2, 4, 6, 9, and 13, granulocyte macrophage colony-stimulating factor (GM- CSF), γ-interferon (IFN-γ), monocyte chemoattractant 1 at week 8 of therapy; that in IL 1β, 1ra, 2, 5, 6, 9, 10, 12, 13, and 15, fibroblast growth factor 2 (FGF-2), GM-CSF, IFN-γ, and tumor necrosis factor-α at week 24, and that in IL-9 at week 40. The no-clinical response group showed a reduction in GM-CSF at week 8 and in IL-2 and macrophage inflammatory protein 1β (MIP-1β) at week 40, and an increase in IL-8 at week 8. At week 8 after drug infusion, the elevated levels of IL-17 and MIP-1β can be identified as possible early pre- dictors of a response (at week 40). Comparison of the baseline cytokine levels in the groups with different clinical response demonstrated a more than three-fold increase in the concentrations of IL 4, 5, 7, 8, 10, 12, 13, 15, 17, IFN-γ, and vascular endothelial growth factor, and IL-8 at weeks 8 and 40, respectively