Information Literacy in Students Entering Higher Education in the French Speaking Community of Belgium: lessons learned from an evaluation

Although universities are providing more and more information literacy training for their undergraduate students, the students’ real level of information literacy at the beginning of their studies has never been assessed. Hence EduDOC has decided to team up with the CIUF ‘Library’ Commission in order to organize a wide study aiming at objectively describing this initial level of information literacy, at identifying the students’ main weaknesses, as well as allowing instructors to adjust their training on this basis. The questionnaire was based on a similar study carried out in Québec and contains 20 questions grouped in five themes relating to information search steps. It was sent in September 2007 to a random sample of students entering a higher education institution in the French Speaking Community of Belgium for the first time. The students’ rather poor results confirm that organizing an information literacy program is imperative if students are to perform well in their studies.Peer reviewe

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk