4 research outputs found
Aggressiveness in different presentations of cluster headache: Results from a controlled multicentric study
Background: The hypothalamus has been discussed as a pivotal structure for both cluster headache (CH) and aggres-siveness, but little is known about the extent of self-reported aggressiveness in patients with CH. Patients and methods: Twenty-six patients with chronic, 25 with active episodic and 22 with episodic CH outside the active period were examined interictally with a validated questionnaire quantifying factors of aggression and compared with 24 migraine patients and 31 headache-free volunteers. Results: The ANOVA was significant for the subscale βself-aggression/depression β (F4, 123 5.771, p< 0.001) with signifi-cant differences between chronic and episodic CH and healthy volunteers. No significant changes were found for other subscales and the sum scale (F4, 123< 1.421, p> 0.230). Especially in the clinically most affected group of patients (chronic CH and active episodic CH), high levels of ββself-aggression/depressionβ β correlate with higher prevalence of depressive symptoms and higher impairment measured on an emotional and functional level. Discussion: Self-aggressive and depressive cognitions with highest scores in chronic CH seem to be reactive as they correlate with depressive symptoms and impairment. They should be considered as an important therapeutic target since they impair the patientβs life significantly
Cluster headache and neuropsychological functioning
Background: Despite significant advances in unravelling the pathophysiology of cluster headache (CH), little is known about neuropsychological functioning. Apart from neuroimaging studies indicating involvement of posterior hypothalamic and other areas frequently involved in nociception, some studies suggest involvement of prefrontal areas. Among others, these mediate executive functioning (EF).
Methods: Therefore, three neuropsychological tests (Trail Making Test (TMT), Go/Nogo Task and Stroop Task) were completed by four headache patient samples (chronic CH, episodic CH in the active or inactive period, and migraine patients) and compared to healthy controls.
Results: Analyses revealed that patients especially with chronic and active episodic CH were particularly impaired in tests relying more on intact EF (i.e. TMT-B, Stroop interference) than on basal cognitive processes (i.e. TMT-A, Stroop naming). Within the CH groups performance decreased linearly with increasing severity.
Discussion: These findings are in line with a recently proposed involvement of prefrontal structures in CH pathophysiology as patients performed worse on neuropsychological tasks relying on these structures. Impaired EF could also result from medication and sleep disturbances due to active CH. Because the decreased performance was also present outside the attacks it may hint at generally altered brain functions, but do not necessarily reflect clinically relevant behaviour
ΠΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² Π½Π°ΡΠΊΠ΅, ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ, ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΡΠ΅ ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅. Π§. 1
Π‘Π±ΠΎΡΠ½ΠΈΠΊ ΠΏΠΎΡΠ²ΡΡΡΠ½ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π°ΡΠΏΠ΅ΠΊΡΠ°ΠΌ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ. ΠΡΠΎΠ±ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»Π΅Π½ΠΎ Π²ΠΎΠΏΡΠΎΡΠ°ΠΌ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΏΡΠ΅Π΄ΠΌΠ΅ΡΠ½ΡΡ
ΠΎΠ±Π»Π°ΡΡΡΡ
. Π ΡΠ±ΠΎΡΠ½ΠΈΠΊΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΡΠΈΡΠΎΠΊΠΈΠΉ ΠΊΡΡΠ³ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠΎΡΡΠΈΠΉΡΠΊΠΈΡ
ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
ΡΡΡΠ½ΡΡ
, ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°ΡΠ΅Π»Π΅ΠΉ, Π°ΡΠΏΠΈΡΠ°Π½ΡΠΎΠ² ΠΈ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ², ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π½Π° IV ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ Β«ΠΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² Π½Π°ΡΠΊΠ΅, ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ, ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΡΠ΅ ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅Β», ΠΏΡΠΎΡΠ΅Π΄ΡΠ΅ΠΉ Π² Π³. Π’ΠΎΠΌΡΠΊΠ΅ Π½Π° Π±Π°Π·Π΅ Π’ΠΎΠΌΡΠΊΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° ΡΠΈΡΡΠ΅ΠΌ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΈ ΡΠ°Π΄ΠΈΠΎΡΠ»Π΅ΠΊΡΡΠΎΠ½ΠΈΠΊΠΈ ΠΈ Π’ΠΎΠΌΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ°