The Clustering of Luminous Red Galaxies in the Sloan Digital Sky Survey Imaging Data

We present the 3D real space clustering power spectrum of a sample of \~600,000 luminous red galaxies (LRGs) measured by the Sloan Digital Sky Survey (SDSS), using photometric redshifts. This sample of galaxies ranges from redshift z=0.2 to 0.6 over 3,528 deg^2 of the sky, probing a volume of 1.5 (Gpc/h)^3, making it the largest volume ever used for galaxy clustering measurements. We measure the angular clustering power spectrum in eight redshift slices and combine these into a high precision 3D real space power spectrum from k=0.005 (h/Mpc) to k=1 (h/Mpc). We detect power on gigaparsec scales, beyond the turnover in the matter power spectrum, on scales significantly larger than those accessible to current spectroscopic redshift surveys. We also find evidence for baryonic oscillations, both in the power spectrum, as well as in fits to the baryon density, at a 2.5 sigma confidence level. The statistical power of these data to constrain cosmology is ~1.7 times better than previous clustering analyses. Varying the matter density and baryon fraction, we find \Omega_M = 0.30 \pm 0.03, and \Omega_b/\Omega_M = 0.18 \pm 0.04, The detection of baryonic oscillations also allows us to measure the comoving distance to z=0.5; we find a best fit distance of 1.73 \pm 0.12 Gpc, corresponding to a 6.5% error on the distance. These results demonstrate the ability to make precise clustering measurements with photometric surveys (abridged).Comment: 23 pages, 27 figures, submitted to MNRA

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

The multisubunit Mediator (MED) complex bridges DNA-bound transcriptional regulators to the RNA polymerase II (PolII) initiation machinery. In yeast, the 25 MED subunits are distributed within three core subcomplexes and a separable kinase module composed of Med12, Med13 and the Cdk8-CycC pair thought to control the reversible interaction between MED and PolII by phosphorylating repeated heptapeptides within the Rpb1 carboxyl-terminal domain (CTD). Here, MED conservation has been investigated across the eukaryotic kingdom. Saccharomyces cerevisiae Med2, Med3/Pgd1 and Med5/Nut1 subunits are apparent homologs of metazoan Med29/Intersex, Med27/Crsp34 and Med24/Trap100, respectively, and these and other 30 identified human MED subunits have detectable counterparts in the amoeba Dictyostelium discoideum, indicating that none is specific to metazoans. Indeed, animal/fungal subunits are also conserved in plants, green and red algae, entamoebids, oomycetes, diatoms, apicomplexans, ciliates and the ‘deep-branching’ protists Trichomonas vaginalis and Giardia lamblia. Surprisingly, although lacking CTD heptads, T. vaginalis displays 44 MED subunit homologs, including several CycC, Med12 and Med13 paralogs. Such observations have allowed the identification of a conserved 17-subunit framework around which peripheral subunits may be assembled, and support a very ancient eukaryotic origin for a large, four-module MED. The implications of this comprehensive work for MED structure–function relationships are discussed

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

25th annual computational neuroscience meeting: CNS-2016

The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong

Sistema constructivo industrializado con placas alveolares y su aplicación en el diseño de una vivienda social en San Martín

Para este trabajo de investigación se tuvo como objetivo validar el diseño de una vivienda social en la región San Martín que emplea el sistema constructivo industrializado con placas alveolares. En lo referente al tipo de estudio empleado fue básico y con un diseño no experimental y estudio de casos. Como resultados principales se encontró que las necesidades de habitabilidad físico espacial que requieren las personas son la distribución espacial, la comodidad en relación al clima y acústica de la vivienda, y la creación de ambientes más adecuados para las actividades; así como también que las características del sistema constructivo industrializado son el confort térmico, el factor de modificación y reutilización de las placas alveolares. Para finalizar, se concluyó que la validación del diseño de una vivienda social se consiguió por medio de la revisión y visto bueno de dos ingenieros y tres arquitectos conocedores del tema dando su aprobación conjunta a la propuesta

Extraction and optimization for modeling ofdesalination by capacitive deionization

Water scarcity is set to become a big challenge in the 21st century and more efficient desalinationtechnologies will be needed in the future. In this project, one desalination method called capacitivedeionization (CDI) is explored and we used a model called the ELC model to simulate CDI withComsol. The goal of this project focuses on evaluating the performance of CDI and how changingdifferent operational parameters of the process affects other aspects of desalination. Some examplesare power consumption, desalination rate and water usage. With the gathered information, the process of CDI can be optimized in some way. Even though our project simulates a specific model ofCDI, the hope is to have come to general conclusions regarding CDI so that the results can be usedfor other models. If the correlations between parameters are known, it will be easier to calibrate anysetup of CDI. The gathered data is exported, stored, processed, and plotted using Matlab functionsintegrated with Comsol. The results consist of two sets, the first for constant voltage and the secondfor constant current. Both have results on how desalination rate and energy efficiency are related toparameters such as internal voltage intervals controlling how long the desalination cycle is running,external voltage, and inflow salt concentration in the water. The key conclusions drawn are as thefollowing for constant voltage. High external voltages are effective in increasing both desalinationrate and energy efficiency but will degrade the CDI electrodes. The internal voltage span should bepretty long with high max internal voltage and the minimum internal voltage the same as the external voltage. The energy efficiency increase with lower salt concentrations in the inflow water up toa point. The best setup for the desalination rate is at quite a high maximum internal voltage withvaried low minimum internal voltage. For constant current, low current is generally efficient, whilethe maximum external voltage depends on the current. Avoid a high current with a low externalvoltage. By relating all these parameters, we get more insights into what an energy-efficient and fastadsorbing CDI setup looks like

Styrelsesammansättning och finansiell prestation : En kvantitativ undersökning på Stockholm Large Cap

Bakgrund: Bolagsstyrning är en kombination av mekanismer som mäter företagsledningens förmåga att effektivisera ett företags finansiella prestation. Ansvaret styrelsen bär inkluderar att sätta företagets strategiska mål och bidra med ledarskap för att kunna verkställa dessa mål. I detta införlivas i allra högsta grad beslut som rör och kommer att beröra den finansiella prestationen. Styrelsesammansättningen för varje enskilt land kan bero på substantiella kulturella skillnader såväl som skillnader i bolagsstyrning, rättssystem, ägarstruktur, styrelsestruktur och chefsincitament. Syfte: Syftet med denna studie är att analysera samband mellan styrelsesammansättning och finansiell prestation hos ett urval av dagens OMX Stockholm Large Cap-företag. Detta genomförs med finansiella variablerna Tobin’s Q och ROA, och styrelsevariablerna könsfördelning och styrelsens storlek.  Slutsats: Resultaten är inte tillräckligt starka för att bekräfta studiens hypoteser. Följaktligen bevisar det att studiens variabler inte har något samband med ett företags finansiella prestation. Fynden stödjer inte tidigare forsknings empiriska resultat och teoretiska perspektiv i den mån att könsfördelning i styrelsen och styrelsens storlek har ett statistiskt signifikant samband med finansiell prestation. Vidare konkluderas att andra styrelsevariabler kan ha större inverkan i svensk kontext. Detta kan förklaras av skillnader i nordisk bolagsstyrning gentemot andra geografiska kontexter där ämnet studerats.

Extraction and optimization for modeling ofdesalination by capacitive deionization

Water scarcity is set to become a big challenge in the 21st century and more efficient desalinationtechnologies will be needed in the future. In this project, one desalination method called capacitivedeionization (CDI) is explored and we used a model called the ELC model to simulate CDI withComsol. The goal of this project focuses on evaluating the performance of CDI and how changingdifferent operational parameters of the process affects other aspects of desalination. Some examplesare power consumption, desalination rate and water usage. With the gathered information, the process of CDI can be optimized in some way. Even though our project simulates a specific model ofCDI, the hope is to have come to general conclusions regarding CDI so that the results can be usedfor other models. If the correlations between parameters are known, it will be easier to calibrate anysetup of CDI. The gathered data is exported, stored, processed, and plotted using Matlab functionsintegrated with Comsol. The results consist of two sets, the first for constant voltage and the secondfor constant current. Both have results on how desalination rate and energy efficiency are related toparameters such as internal voltage intervals controlling how long the desalination cycle is running,external voltage, and inflow salt concentration in the water. The key conclusions drawn are as thefollowing for constant voltage. High external voltages are effective in increasing both desalinationrate and energy efficiency but will degrade the CDI electrodes. The internal voltage span should bepretty long with high max internal voltage and the minimum internal voltage the same as the external voltage. The energy efficiency increase with lower salt concentrations in the inflow water up toa point. The best setup for the desalination rate is at quite a high maximum internal voltage withvaried low minimum internal voltage. For constant current, low current is generally efficient, whilethe maximum external voltage depends on the current. Avoid a high current with a low externalvoltage. By relating all these parameters, we get more insights into what an energy-efficient and fastadsorbing CDI setup looks like

Styrelsesammansättning och finansiell prestation : En kvantitativ undersökning på Stockholm Large Cap

Bakgrund: Bolagsstyrning är en kombination av mekanismer som mäter företagsledningens förmåga att effektivisera ett företags finansiella prestation. Ansvaret styrelsen bär inkluderar att sätta företagets strategiska mål och bidra med ledarskap för att kunna verkställa dessa mål. I detta införlivas i allra högsta grad beslut som rör och kommer att beröra den finansiella prestationen. Styrelsesammansättningen för varje enskilt land kan bero på substantiella kulturella skillnader såväl som skillnader i bolagsstyrning, rättssystem, ägarstruktur, styrelsestruktur och chefsincitament. Syfte: Syftet med denna studie är att analysera samband mellan styrelsesammansättning och finansiell prestation hos ett urval av dagens OMX Stockholm Large Cap-företag. Detta genomförs med finansiella variablerna Tobin’s Q och ROA, och styrelsevariablerna könsfördelning och styrelsens storlek.  Slutsats: Resultaten är inte tillräckligt starka för att bekräfta studiens hypoteser. Följaktligen bevisar det att studiens variabler inte har något samband med ett företags finansiella prestation. Fynden stödjer inte tidigare forsknings empiriska resultat och teoretiska perspektiv i den mån att könsfördelning i styrelsen och styrelsens storlek har ett statistiskt signifikant samband med finansiell prestation. Vidare konkluderas att andra styrelsevariabler kan ha större inverkan i svensk kontext. Detta kan förklaras av skillnader i nordisk bolagsstyrning gentemot andra geografiska kontexter där ämnet studerats.

The patients’ perspective on the burden of idiopathic intracranial hypertension

Background!#!Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure without evidence of a tumor or any other underlying cause. Headache and visual disturbances are frequent complaints of IIH patients, but little is known about other symptoms. In this study, we evaluated the patients' perspective on the burden of IIH.!##!Methods!#!For this cross-sectional study, we developed an online survey for patients with IIH containing standardized evaluations of headache (HIT-6), sleep (PROMIS Sleep Disturbance Scale) and depression (MDI) in relation to BMI, lumbar puncture opening pressure (LP OP) and treatment.!##!Results!#!Between December 2019 and February 2020, 306 patients completed the survey. 285 (93 %) were female, mean age was 36.6 years (± 10.8), mean BMI 34.2 (± 7.3) and mean LP OP at diagnosis was 37.8 cmH!##!Conclusions!#!In addition to headaches and visual disturbances, sleep disturbances and depression are frequent symptoms in IIH and contribute to the patients' burden. Structured questionnaires can help to identify IIH patients' needs and can lead to personalized and better treatment