Identifying patient‐ and family‐centered outcomes relevant to inpatient versus at‐home management of neutropenia in children with acute myeloid leukemia

Efficacy of therapeutic strategies relative to patient‐ and family‐centered outcomes in pediatric oncology must be assessed. We sought to identify outcomes important to children with acute myeloid leukemia and their families related to inpatient versus at‐home management of neutropenia. We conducted qualitative interviews with 32 children ≥8 years old and 54 parents. Analysis revealed the impact of neutropenia management strategy on siblings, parent anxiety, and child sleep quality as being outcomes of concern across respondents. These themes were used to inform the design of a questionnaire that is currently being used in a prospective, multiinstitutional comparative effectiveness trial.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142562/1/pbc26927.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142562/2/pbc26927_am.pd

Effects of Music on Physiological Response

For this study the heart rates of twenty-two members of a college-level music appreciation class were recorded while students listened to the first movement of Beethoven's fifth symphony. The measurements were taken at three different times over a six-week period before, during, and after experimental treatment. Experimental treatment consisted of either audiotutorial tapes or repetitive listening sessions devised for specific musical-ability groups. The same test music was used throughout the entire study to determine the effects of learning and repetitive exposure on heart rate response. A control group had no further exposure to the test music during the study. Stable segments of the test music provoked tachycardia (elevated heart rate) in the subjects, while alternating segments produced bradycardia (lowered heart rate). Heart rate response to music was found to be linked with the presence or absence of learning.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Multiple Nuclear Gene Phylogenetic Analysis of the Evolution of Dioecy and Sex Chromosomes in the Genus Silene

In the plant genus Silene, separate sexes and sex chromosomes are believed to have evolved twice. Silene species that are wholly or largely hermaphroditic are assumed to represent the ancestral state from which dioecy evolved. This assumption is important for choice of outgroup species for inferring the genetic and chromosomal changes involved in the evolution of dioecy, but is mainly based on data from a single locus (ITS). To establish the order of events more clearly, and inform outgroup choice, we therefore carried out (i) multi-nuclear-gene phylogenetic analyses of 14 Silene species (including 7 hermaphrodite or gynodioecious species), representing species from both Silene clades with dioecious members, plus a more distantly related outgroup, and (ii) a BayesTraits character analysis of the evolution of dioecy. We confirm two origins of dioecy within this genus in agreement with recent work on comparing sex chromosomes from both clades with dioecious species. We conclude that sex chromosomes evolved after the origin of Silene and within a clade that includes only S. latifolia and its closest relatives. We estimate that sex chromosomes emerged soon after the split with the ancestor of S. viscosa, the probable closest non-dioecious S. latifolia relative among the species included in our study