3 research outputs found
Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis
Secretory leukocyte protease inhibitor (SLPI), a pleiotropic protein expressed by healthy intestinal epithelial cells, functions as an inhibitor of NF-κB and neutrophil proteases and exerts antimicrobial activity. We
previously showed SLPI suppresses intestinal epithelial chemokine production in response to microbial
contact. Increased SLPI expression was recently detected in various types of carcinoma. In addition,
accumulating evidence indicates SLPI expression is favorable for tumor cells. In view of these findings
and the abundance of SLPI in the colonic epithelium, we hypothesized SLPI promotes colorectal cancer
(CRC) growth and metastasis. Here, we aimed to establish wh