Pelvic Exenterative Therapy and Recurrent Pelvic Carcinoma1

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135384/1/ijgo00332.pd

Canine Aortofemoral Bypass: a New Technique for the Evaluation of Prosthetic Implants

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67957/2/10.1177_000331977402500901.pd

Distribution of intrarenal blood flow during bacterial Sepsis

Inappropriate polyuria during bacterial sepsis represents a poorly understood clinical entity. This study employed live Pseudomonas aeruginosa infusion to simulate this disorder in awake dogs. Intrarenal blood flow distribution was measured using radioactivity labeled microspheres. Hypotension, leucopenia, hemoconcentration, pyrexia, polyuria, and natriuresis were produced. Most dogs showed increased total renal blood flow. Redistribution of renal blood flow away from the outer cortex toward the juxtamedullary cortex, as well as increased absolute perfusion of the juxtamedullary cortex, occurred. Washout of the medullary interstitial concentration gradient by increased blood flow can explain the observed diuresis. These results support but do not prove a causal relationship between redistributed intrarenal blood flow and polyuria during bacterial sepsis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22641/1/0000192.pd

Serial arteriography of the dog: A simplified technique

A new technique for serial arteriography of the infradiaphragmatic arterial system in the experimental animal has been developed. Utilizing this technique 143 arteriograms have been obtained at weekly intervals in 24 dogs for up to 10 weeks. Advantages of the method are reproducible results, inexpensive equipment required, and ease of obtaining high-quality arteriograms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34186/1/0000475.pd

Hemodynamic effects of cecal ligation sepsis in dogs

Cecal ligation sepsis was studied in eight pentobarbital-anesthetized dogs with hemodynamic measurements at baseline, 2 days after cecal ligation, and following Ringer's lactate resuscitation. Microsphere techniques were used to measure peripheral arteriovenous (A-V) shunting and distribution of cardiac output. Cecal ligation sepsis was manifested by pyrexia, leukocytosis, decreased blood pressure, and purulent peritonitis. Although cardiac index (CI) increased in two, decreased in four, and was unchanged in two dogs, femoral artery blood flow (FAQ) decreased in all animals (125 to 84 ml/min, P 2 difference increased while O2 consumption and A-V shunting did not change. Distribution of cardiac output increased significantly to the kidneys (163%, P P 2 differences returned to baseline values. Hindlimb A-V shunting remained low and unchanged.In contrast to the effects of local inflammation in canine septic hindlimbs, there does not appear to be a specific vasodilator released during cecal ligation sepsis which causes increased peripheral blood flow and elevated A-V shunting. Cecal ligation in dogs, however, does not mimic the disproportionately low peripheral resistance and reduced O2 extraction seen in hyperdynamic human sepsis. These results should, therefore, be interpreted with caution.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23853/1/0000092.pd

Vaginal evisceration

A patient with vaginal evisceration due to prior radiation treatment of cervical carcinoma is presented, together with a review of reported cases. The salient features, predisposing causes and management of this unusual problem are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24293/1/0000559.pd

The effect of bacterial pyrogen on the distribution of intrarenal blood flow

Hemodynamic and biochemical measurements were made before and 90 min after 50 [mu]g of Pseudomonas-derived pyrogen was infused into nine awake dogs. Six control dogs received no pyrogen. Total renal blood flow (RBF) and intrarenal distribution of blood flow to four equal cortical zones (outer to juxtamedullary) were determined by the radioactive microsphere method. Pyrogen administration produced tachycardia, pyrexia, polyuria, natriuresis, and increased RBF. Cardiac output, arterial pressure, hematocrit, creatinine clearance, and white blood cell count did not change significantly. Despite increased total RBF, distribution of blood flow within the renal cortex did not change significantly after pyrogen administration. When compared with the effect of live bacteria, these studies suggest that polyuria and natriuresis result from any increased juxtamedullary blood flow without being dependent on redistribution, per se. Furthermore, the detrimental renal effect of bacterial sepsis may be related to the relative outer cortical hypoperfusion in contrast to the benign renal effect of pyrogen where no redistribution of blood flow occurs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23620/1/0000583.pd

AN EX VIVO METHOD FOR THE EVALUATION OF BIOMATERIALS IN CONTACT WITH BLOOD *

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73650/1/j.1749-6632.1977.tb41793.x.pd

Circulation studies in experimental phlegmasia cerulea dolens

A model of phlegmasia cerulea dolens in the canine hind limb was used to study the effects of heparin, sympathectomy, and venous thrombectomy plus heparin on limb hemodynamics. Only thrombectomy plus heparin restored nutrient blood flow and was associated with clinical recovery of the limb. This experimental model of phlegmasia appears to be an excellent tool for testing additional modalities of therapy for this serious disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/21765/1/0000159.pd

Corticosteroids in experimental fat embolization

Adult mongrel dogs were given intravenous oleic acid in an experimental model of pulmonary fat embolism. The changes in PaO2, chest roentgenograms, and pulmonary tissues were less marked when high doses of corticosteroids were administered.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33929/1/0000196.pd