4,225 research outputs found

    Cold Spring Harbor Central School District and Cold Spring Harbor Teachers Association

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    In the matter of the fact-finding between Cold Spring Harbor Central School District, employer, and the Cold Spring Harbor Teachers Association, union. PERB case no. M2012-330. Before: Thomas J. Linden, fact finder

    Uniondale Union Free School District and United Public Service Employees Union (UPSEU)

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    In the matter of the fact-finding between the Uniondale Union Free School DIstrict, employer, and the United Public Service Employees Union (UPSEU), union. PERB case no. M2015-096. Before: Thomas J. Linden, fact finder

    Northport-East Northport Union Free School District and United Public Service Employees Union (UPSEU)

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    In the matter of the fact-finding between the Northport-East Northport Union Free School District, employer, and the United Public Service Employees Union (UPSEU), union. PERB case no. M2014-056. Before: Thomas J. Linden, fact finder

    West Babylon Union Free School District and West Babylon Non-Teaching Unit, CSEA, Local 1000 AFSCME, AFL-CIO

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    In the matter of the fact-finding between the West Babylon Union Free School District, employer, and the West Babylon Non-Teaching Unit, CSEA, Local 1000 AFSCME, AFL-CIO, union. PERB case no. M2017-044. Before: Thomas J. Linden, fact finder.m2017_044.pdf: 19 downloads, before Oct. 1, 2020

    Mattituck-Cutchogue Union Free School District and Mattituck-Cutchogue Teachers Association

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    In the matter of the fact-finding between the Mattituck-Cutchogue Union Free School District, employer, and the Mattituck-Cutchogue Teachers Association, union. PERB case no. M2015-135. Before: Thomas J. Linden, fact finder

    West Islip Union Free School District and United Public Service Union (UPSEU)

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    In the matter of the fact-finding between the West Islip Union Free School District, employer, and the Union Public Service Employees Union, union. PERB case no. M2017-018. Before: Thomas J. Linden, fact finder

    Rotating gravity currents: small-scale and large-scale laboratory experiments and a geostrophic model

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    Laboratory experiments simulating gravity-driven coastal surface currents produced by estuarine fresh-water discharges into the ocean are discussed. The currents are generated inside a rotating tank filled with salt water by the continuous release of buoyant fresh water from a small source at the fluid surface. The height, the width and the length of the currents are studied as a function of the background rotation rate, the volumetric discharge rate and the density difference at the source. Two complementary experimental data sets are discussed and compared with each other. One set of experiments was carried out in a tank of diameter 1 m on a small-scale rotating turntable. The second set of experiments was conducted at the large-scale Coriolis Facility (LEGI, Grenoble) which has a tank of diameter 13 m. A simple geostrophic model predicting the current height, width and propagation velocity is developed. The experiments and the model are compared with each other in terms of a set of non-dimensional parameters identified in the theoretical analysis of the problem. These parameters enable the corresponding data of the large-scale and the small-scale experiments to be collapsed onto a single line. Good agreement between the model and the experiments is found

    Antibody responses to a Cryptosporidium parvum rCP15/60 vaccine

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    Cryptosporidium parvum is a zoonotic apicomplexa-protozoan pathogen that causes gastroenteritis and diarrhoea in mammals worldwide. The organism is transmitted by ingestion of oocysts, which are shed in faeces, and completes its lifecycle in a single host.^1^ C. parvum is ubiquitous on dairy operations worldwide and is one of the leading causes of diarrhoea in calves on these farms.^2,3^ Here, for the first time, we describe the antibody response in a large group of cows to a recombinant C. parvum oocyst surface protein (rCP15/60) vaccine and the antibody response in calves fed rCP15/60-immune colostrum produced by these vaccinated cows. Results of recent genotype surveys indicate that calves are the only major reservoir for C. parvum infections in humans.^4^ Human C. parvum infections are particularly prevalent and often fatal in neonates in developing countries and to immunocompromised people, such as AIDs patients.^4^ Drug therapy against cryptosporidiosis is limited and not wholly efficacious in either humans or calves^5^, making development of an effective vaccine of paramount importance. To date, there is no commercially available effective vaccine against C. parvum, although passive immunization utilizing different zoite surface (glyco)proteins has showed promise.^6-9^ All cows we vaccinated produced an antibody response to the rCP15/60 vaccine and the magnitude of response correlated strongly with the subsequent level of antibody in their colostrum. All calves fed rCP15/60-immune colostrum showed a dose-dependent absorption of antibody. Our results demonstrate that vaccination of cows with rCP15/60 successfully induces antibodies against CP15/60 in their serum and colostrum and that these antibodies are then well absorbed when fed to neonatal calves. With further research, this C. parvum vaccine may well be a practical method of conferring passive protection to calves against cryptosporidiosis. Furthermore, a specifically targeted immune-colostrum may be valuable in protection and treatment of immunocompromised human patients with cryptosporidiosis
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