Linköping University Medical Dissertation

Immune mechanisms in Borrelia burgdorferi sensu lato infection in relation to clinical outcom

N.B.: When citing this work, cite the original article. Original Publication:

Low risk of developing Borrelia burgdorferi infection in the south-east of Sweden after being bitten by a Borrelia burgdorferi-infected tic

Northern Europe: seasonal pattern of infestation,

Ixodes ricinus ticks removed from humans i

http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-62152 Prevalence and Diversity of Borrelia Species in Ticks that have Bitten Humans in Sweden

Members of the genus Borrelia are among the most common infectious agents causing tickborne disease in humans worldwide. Here, we developed a Light Upon eXtension ™ (LUX) real-time PCR assay that can detect and quantify Borrelia species in ticks that have fed on humans, and we applied the assay to 399 such ticks. Borrelia PCR-positive ticks were identified to species by sequencing the products of conventional PCR performed using Borrelia group-specific primers. There was a 19 % prevalence of Borrelia spp. in the detache