1 research outputs found
Relationship between total vitamin D metabolites and complications in patients with type 2 diabetes
In our previous study, it was
shown that endogenous vitamin D3 and its metabolites are associated with diabetic
microvascular complications and cardiovascular risk factors. The aim of the
present study was to determine if the relationship between total vitamin D
(vitamin D2 supplements plus endogenous vitamin D3) was a better predictor of complications in type 2 diabetes
(T2DM). A total of 460 patients with T2DM participated in the present
cross-sectional study. Plasma levels of total vitamin D and its metabolites
(1,25-dihydroxyvitamin D (1,25(OH)D), 25-hydroxyvitamin D (25(OH)D) and
24,25-dihydroxyvitamin D (24,25(OH)D) were measured by isotope-dilution liquid
chromatography tandem mass spectrometry analysis. 1,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 were associated with diabetic retinopathy and coronary
artery disease, but total 1,25-dihydroxyvitamin D and total 25-hydroxyvitamin D
levels were not statistically associated with any complications. Total
1,25-dihydroxyvitamin D showed the same positive association as
1,25-dihydroxyvitamin D3 for hypertension and dyslipidemia, and total
25-hydroxyvitamin D showed the same positive association as 25-hydroxyvitamin D3 for dyslipidemia. Total 24,25-dihydroxyvitamin D showed
the same positive association only with dyslipidemia as did
24,25-dihydroxyvitamin D3. However, total 25-hydroxyvitamin D was associated with
hypertension, whereas 25-hydroxyvitamin D3 was not. Vitamin D3 metabolites were associated with diabetic retinopathy,
whereas total vitamin D levels were not, suggesting that endogenous vitamin D3 metabolites are a better measure of diabetic
microvascular complications. However, both total vitamin D and vitamin D3 metabolites were associated with cardiovascular risk
factors in patients with type 2 diabetes.<br