Large deviations for two scale chemical kinetic processes

We formulate the large deviations for a class of two scale chemical kinetic processes motivated from biological applications. The result is successfully applied to treat a genetic switching model with positive feedbacks. The corresponding Hamiltonian is convex with respect to the momentum variable as a by-product of the large deviation theory. This property ensures its superiority in the rare event simulations compared with the result obtained by formal WKB asymptotics. The result is of general interest to understand the large deviations for multiscale problems

Entanglement renormalization and integral geometry

We revisit the applications of integral geometry in AdS$_3$ and argue that the metric of the kinematic space can be realized as the entanglement contour, which is defined as the additive entanglement density. From the renormalization of the entanglement contour, we can holographically understand the operations of disentangler and isometry in multi-scale entanglement renormalization ansatz. Furthermore, a renormalization group equation of the long-distance entanglement contour is then derived. We then generalize this integral geometric construction to higher dimensions and in particular demonstrate how it works in bulk space of homogeneity and isotropy.Comment: 40 pages, 7 figures. v2: discussions on the general measure added, typos fixed; v3: sections reorganized, various points clarified, to appear in JHE

Relative Entropy and Torsion Coupling

We evaluate the relative entropy on a ball region near the UV fixed point of a holographic conformal field theory deformed by a fermionic operator of nonzero vacuum expectation value. The positivity of the relative entropy considered here is implied by the expected monotonicity of decrease of quantum entanglement under RG flow. The calculations are done in the perturbative framework of Einstein-Cartan gravity in four-dimensional asymptotic anti-de Sitter space with a postulated standard bilinear coupling between axial fermion current and torsion. By requiring positivity of relative entropy, our result yields a constraint on axial current-torsion coupling, fermion mass and equation of state.Comment: 31 pages; match the version accepted by PR

Holographic QCD with Topologically Charged Domain-Wall/Membranes

We study the thermodynamical phase structures of holographic QCD with nontrivial topologically charged domain-wall/membranes which are originally related to the multiple $\theta$-vacua in the large $N_c$ limit. We realize the topologically charged membranes as the holographic D6-brane fluxes in the Sakai-Sugimoto model. The D6-brane fluxes couple to the probe D8-anti-D8 via Chern-Simon term, and act as the source for the baryonic current density of QCD. We find rich phase structures of the dual meson system by varying asymptotic separation of D8 and anti-D8. Especially, there can be a thermodynamically favored and stable phase of finite baryonic current density. This provides the supporting evidence for the discovery of the topologically charged membranes found in the lattice QCD calculations. We also find a crossover phase with the limiting baryonic current density and temperature which suggest a Hagedorn-like phase transition of meson dissociation.Comment: 23 pages, 19 figures;v2 typos corrected;v3 text improve

Quantum measurement in two-dimensional conformal field theories: Application to quantum energy teleportation

We construct a set of quasi-local measurement operators in 2D CFT, and then use them to proceed the quantum energy teleportation (QET) protocol and show it is viable. These measurement operators are constructed out of the projectors constructed from shadow operators, but further acting on the product of two spatially separated primary fields. They are equivalently the OPE blocks in the large central charge limit up to some UV-cutoff dependent normalization but the associated probabilities of outcomes are UV-cutoff independent. We then adopt these quantum measurement operators to show that the QET protocol is viable in general. We also check the CHSH inequality a la OPE blocks.Comment: match the version published on PLB, the main conclusion didn't change, some techincal details can be found in the previous versio

Two-scale large deviations for chemical reaction kinetics through second quantization path integral

Motivated by the study of rare events for a typical genetic switching model in systems biology, in this paper we aim to establish the general two-scale large deviations for chemical reaction systems. We build a formal approach to explicitly obtain the large deviation rate functionals for the considered two-scale processes based upon the second-quantization path integral technique. We get three important types of large deviation results when the underlying two times scales are in three different regimes. This is realized by singular perturbation analysis to the rate functionals obtained by path integral. We find that the three regimes possess the same deterministic mean-field limit but completely different chemical Langevin approximations. The obtained results are natural extensions of the classical large volume limit for chemical reactions. We also discuss its implication on the single-molecule Michaelis-Menten kinetics. Our framework and results can be applied to understand general multi-scale systems including diffusion processes