Enhancing the Supply Chain Performance by Integrating Simulated and Physical Agents into Organizational Information Systems

As the business environment gets more complicated, organizations must be able to respond to the business changes and adjust themselves quickly to gain their competitive advantages. This study proposes an integrated agent system, called SPA, which coordinates simulated and physical agents to provide an efficient way for organizations to meet the challenges in managing supply chains. In the integrated framework, physical agents coordinate with inter-organizations\' physical agents to form workable business processes and detect the variations occurring in the outside world, whereas simulated agents model and analyze the what-if scenarios to support physical agents in making decisions. This study uses a supply chain that produces digital still cameras as an example to demonstrate how the SPA works. In this example, individual information systems of the involved companies equip with the SPA and the entire supply chain is modeled as a hierarchical object oriented Petri nets. The SPA here applies the modified AGNES data clustering technique and the moving average approach to help each firm generalize customers\' past demand patterns and forecast their future demands. The amplitude of forecasting errors caused by bullwhip effects is used as a metric to evaluate the degree that the SPA affects the supply chain performance. The experimental results show that the SPA benefits the entire supply chain by reducing the bullwhip effects and forecasting errors in a dynamic environment.Supply Chain Performance Enhancement; Bullwhip Effects; Simulated Agents; Physical Agents; Dynamic Customer Demand Pattern Discovery

Asthma Exacerbation in Children: A Practical Review

Asthma is the most common chronic lower respiratory tract disease in childhood throughout the world. Despite advances in asthma management, acute exacerbations continue to be a major problem in patients and they result in a considerable burden on direct/indirect health care providers. A severe exacerbation occurring within 1 year is an independent risk factor. Respiratory tract viruses have emerged as the most frequent triggers of exacerbations in children. It is becoming increasingly clear that interactions may exist between viruses and other triggers, increasing the likelihood of an exacerbation. In this study, we provide an overview of current knowledge about asthma exacerbations, including its definition, impact on health care providers, and associated factors. Prevention management in intermittent asthma as well as intermittent wheeze in pre-school children and those with persistent asthma are discussed. Our review findings support the importance of controlling persistent asthma, as indicated in current guidelines. In addition, we found that early episodic intervention appeared to be crucial in preventing severe attacks and future exacerbations. Besides the use of medication, timely education after an exacerbation along with a comprehensive plan in follow up is also vitally important