Research on Kindergarten Diet Education from the Perspective of Life Education

Based on understanding the necessity of diet and life education, this research presents the concept of building life education step by step and divides the structure of kindergarten diet education into two sides and three levels. The study investigates the current situation of diet education in a kindergarten using interviews and observation. To promote the integration of life education and diet education, this paper discusses how insights from the perspective of life education can illuminate poor practices in kindergarten diet education and provides proposals for improving the quality of diet education for children

In vitro evaluation of bond strength and sealing ability of a new low-shrinkage, methacrylate resin-based root canal sealer

Background/PurposeThe aim of this study was to evaluate a new low-shrinkage, methacrylate resin-based root canal sealer (LSRCS) to determine its bond strength in radicular dentin and sealing ability.MethodsExtracted single-root teeth were randomly divided into three experimental groups (n=20) for obturation with Gutta-percha (GP)/AH Plus, Resilon/Epiphany, or Resilon/LSRCS. One-half of each experimental group was analyzed by the push-out test, using sections perpendicular to the long axis divided into 1mm serial slices and a universal testing machine to detect the loading force. The other half was analyzed by the dye penetration test using 2% methylene blue solution (pH=7) and measuring dye leakage under a stereomicroscope.ResultsThe push-out test revealed significant differences (p<0.05) in bond strength produced by the three sealers; the GP/AH Plus group showed the highest bond strength, followed by Resilon/LSRCS and Resilon/Epiphany. According to the microleakage data, GP/AH Plus showed the least dye penetration, which was significantly less than Resilon/Epiphany and Resilon/LSRCS. There was no difference in apical leakage between Resilon/Epiphany and Resilon/LSRCS.ConclusionThe newly developed LSRCS, although not superior to AH Plus in bond strength or sealing ability, possesses monoblock potential and application prospects

The downstream of tyrosine kinase 7 is reduced in lung cancer and is associated with poor survival of patients with lung cancer

The downstream of tyrosine kinase 7 (DOK7) is an adaptor protein mediating signalling transduction between receptors and intracellular downstream molecules. Reduced expression of DOK7 has been observed in breast cancer. The present study aimed to investigate the role played by DOK7 in lung cancer. The expression of DOK7 at both mRNA and protein levels was evaluated in human lung cancer. A reduced expression of DOK7 transcripts was seen in lung cancers compared with normal lung tissues. Kaplan-Meier analyses showed that the reduced expression of DOK7 was associated with poorer overall survival and progression-free survival of patients with lung cancer. A further western blot analysis revealed a predominant expression of DOK7 isoform 1 (DOK7V1) in normal lung tissues, which was reduced in lung cancer. Forced overexpression of DOK7V1 in lung cancer cell lines, A549 and H3122 resulted in a decrease of in vitro cell proliferation and migration, while adhesion to extracellular matrix was enhanced following the expression. In conclusion, DOK7 was reduced in lung cancer and reduced DOK7 expression was associated with poorer survival. DOK7 isoform 1 plays an inhibitory role on the proliferation and migration of lung cancer cells in which Akt pathway may be involved

Expert consensus on digital intraoral scanning technology

Digital intraoral scanning is a hot topic in the field of oral digital technology. In recent years, digital intraoral scanning has gradually become the mainstream technology in orthodontics, prosthodontics, and implant dentistry. The precision of digital intraoral scanning and the accuracy and stitching of data collection are the keys to the success of the impression. However, the operators are less familiar with the intraoral scanning characteristics, imaging processing, operator scanning method, oral tissue specificity of the scanned object, and restoration design. Thus far, no unified standard and consensus on digital intraoral scanning technology has been achieved at home or abroad. To deal with the problems encountered in oral scanning and improve the quality of digital scanning, we collected common expert opinions and sought to expound the causes of scanning errors and countermeasures by summarizing the existing evidence. We also describe the scanning strategies under different oral impression requirements. The expert consensus is that due to various factors affecting the accuracy of digital intraoral scanning and the reproducibility of scanned images, adopting the correct scanning trajectory can shorten clinical operation time and improve scanning accuracy. The scanning trajectories mainly include the E-shaped, segmented, and S-shaped methods. When performing fixed denture restoration, it is recommended to first scan the abutment and adjacent teeth. When performing fixed denture restoration, it is recommended to scan the abutment and adjacent teeth first. Then the cavity in the abutment area is excavated. Lastly, the cavity gap was scanned after completing the abutment preparation. This method not only meets clinical needs but also achieves the most reliable accuracy. When performing full denture restoration in edentulous jaws, setting markers on the mucosal tissue at the bottom of the alveolar ridge, simultaneously capturing images of the vestibular area, using different types of scanning paths such as Z-shaped, S-shaped, buccal-palatal and palatal-buccal pathways, segmented scanning of dental arches, and other strategies can reduce scanning errors and improve image stitching and overlap. For implant restoration, when a single crown restoration is supported by implants and a small span upper structure restoration, it is recommended to first pre-scan the required dental arch. Then the cavity in the abutment area is excavated. Lastly, scanning the cavity gap after installing the implant scanning rod. When repairing a bone level implant crown, an improved indirect scanning method can be used. The scanning process includes three steps: First, the temporary restoration, adjacent teeth, and gingival tissue in the mouth are scanned; second, the entire dental arch is scanned after installing a standard scanning rod on the implant; and third, the temporary restoration outside the mouth is scanned to obtain the three-dimensional shape of the gingival contour of the implant neck, thereby increasing the stability of soft tissue scanning around the implant and improving scanning restoration. For dental implant fixed bridge repair with missing teeth, the mobility of the mucosa increases the difficulty of scanning, making it difficult for scanners to distinguish scanning rods of the same shape and size, which can easily cause image stacking errors. Higher accuracy of digital implant impressions can be achieved by changing the geometric shape of the scanning rods to change the optical curvature radius. The consensus confirms that as the range of scanned dental arches and the number of data concatenations increases, the scanning accuracy decreases accordingly, especially when performing full mouth implant restoration impressions. The difficulty of image stitching processing can easily be increased by the presence of unstable and uneven mucosal morphology inside the mouth and the lack of relatively obvious and fixed reference objects, which results in insufficient accuracy. When designing restorations of this type, it is advisable to carefully choose digital intraoral scanning methods to obtain model data. It is not recommended to use digital impressions when there are more than five missing teeth

Bridge Seismic Damage Assessment Model Applying Artificial Neural Networks and the Random Forest Algorithm

Earthquakes cause significant damage to bridges, which have a very strategic location in transportation services. The destruction of a bridge will seriously hinder emergency rescue. Rapid assessment of bridge seismic damage can help relevant departments to make judgments quickly after earthquakes and save rescue time. This paper proposed a rapid assessment method for bridge seismic damage based on the random forest algorithm (RF) and artificial neural networks (ANN). This method evaluated the relative importance of each uncertain influencing factor of the seismic damage to the girder bridges and arch bridges, respectively. The input variables of the ANN model were the factors with higher importance value, and the output variables were damage states. The data of the Wenchuan earthquake were used as a testing set and a training set, and the data of the Tangshan earthquake were used as a validation set. The bridges under serious and complete damage states are not accessible after earthquakes and should be overhauled and reinforced before earthquakes. The results demonstrate that the proposed approach has good performance for assessing the damage states of the two bridges. It is robust enough to extend and improve emergency decisions, to save time for rescue work, and to help with bridge construction

An Earthquake Fatalities Assessment Method Based on Feature Importance with Deep Learning and Random Forest Models

This study aims to analyze and compare the importance of feature affecting earthquake fatalities in China mainland and establish a deep learning model to assess the potential fatalities based on the selected factors. The random forest (RF) model, classification and regression tree (CART) model, and AdaBoost model were used to assess the importance of nine features and the analysis showed that the RF model was better than the other models. Furthermore, we compared the contributions of 43 different structure types to casualties based on the RF model. Finally, we proposed a model for estimating earthquake fatalities based on the seismic data from 1992 to 2017 in China mainland. These results indicate that the deep learning model produced in this study has good performance for predicting seismic fatalities. The method could be helpful to reduce casualties during emergencies and future building construction

Changes in Quality and Myofibrillar Protein Functional Properties of Two Kinds of Cuttlefish during Frozen Storage

To investigate the changes of quality and myofibrillar protein functional properties of Sepiella maindroni and Sepia esculenta during frozen storage, the two kinds of cuttlefish were frozen at −18 ℃ for 0, 30, 60, 90 and 120 days. The water content, water activity, texture, color difference and total volatile base nitrogen (TVB-N) were measured. Hematoxylin-eosin (HE) staining and scanning electronic microscopy (SEM) were used to observe the changes of muscle quality of the two cuttlefish species. The functional properties of myofibrillar proteins of the two cuttlefish species were evaluated by total sulfhydryl, carbonyl content and Ca2+-ATPase activity. The results showed that compared with fresh cuttlefish, after 120 days of frozen storage, the water content and water activity of the two cuttlefish muscles to decrease, but the Sepia esculenta decreased faster. There was no significant difference in the elasticity of the two kinds of cuttlefish muscle, and the hardness, chewiness and adhesiveness decreased first and then stabilized. The whiteness, L*, total sulfhydryl content and Ca2+-ATPase activity of the two cuttlefish species continued to decrease, TVB-N and carbonyl content to increase, and b* showed a dynamic change trend of first decline and then rise. After 90 days of frozen storage, the TVB-N content of Sepiella maindroni and Sepia esculenta muscle was 19.00 and 20.22 mg/100 g, respectively. Compared with fresh cuttlefish, they increased by 29.41% and 73.42% respectively after 120 days of frozen storage, and the rise rate of Sepia esculenta was faster. After 120 days of frozen storage, the sulfhydryl content and Ca2+-ATPase activity of the two cuttlefish species decreased to the minimum, which decreased by 52.28%, 56.12% and 70.93%, 72.00%, respectively. Compared with fresh cuttlefish, the microstructure of frozen 120 d showed that the muscle tissue of Sepiella maindroni was gelatinized into minced meat, the muscle fiber distribution of Sepia esculenta was disordered and the pores were increased. The results provide theoretical support for the quality control of the cold chain storage process of Sepiella maindroni and Sepia esculenta