Consistent123: One Image to Highly Consistent 3D Asset Using Case-Aware Diffusion Priors

Reconstructing 3D objects from a single image guided by pretrained diffusion models has demonstrated promising outcomes. However, due to utilizing the case-agnostic rigid strategy, their generalization ability to arbitrary cases and the 3D consistency of reconstruction are still poor. In this work, we propose Consistent123, a case-aware two-stage method for highly consistent 3D asset reconstruction from one image with both 2D and 3D diffusion priors. In the first stage, Consistent123 utilizes only 3D structural priors for sufficient geometry exploitation, with a CLIP-based case-aware adaptive detection mechanism embedded within this process. In the second stage, 2D texture priors are introduced and progressively take on a dominant guiding role, delicately sculpting the details of the 3D model. Consistent123 aligns more closely with the evolving trends in guidance requirements, adaptively providing adequate 3D geometric initialization and suitable 2D texture refinement for different objects. Consistent123 can obtain highly 3D-consistent reconstruction and exhibits strong generalization ability across various objects. Qualitative and quantitative experiments show that our method significantly outperforms state-of-the-art image-to-3D methods. See https://Consistent123.github.io for a more comprehensive exploration of our generated 3D assets

Patchouli alcohol improved diarrhea-predominant irritable bowel syndrome by regulating excitatory neurotransmission in the myenteric plexus of rats

Background and Purpose: Irritable bowel syndrome (IBS) is usually associated with chronic gastrointestinal disorders. Its most common subtype is accompanied with diarrhea (IBS-D). The enteric nervous system (ENS) modulates major gastrointestinal motility and functions whose aberration may induce IBS-D. The enteric neurons are susceptible to long-term neurotransmitter level alterations. The patchouli alcohol (PA), extracted from Pogostemonis Herba, has been reported to regulate neurotransmitter release in the ENS, while its effectiveness against IBS-D and the underlying mechanism remain unknown.Experimental Approach: In this study, we established an IBS-D model in rats through chronic restraint stress. We administered the rats with 5, 10, and 20 mg/kg of PA for intestinal and visceral examinations. The longitudinal muscle myenteric plexus (LMMP) neurons were further immunohistochemically stained for quantitative, morphological, and neurotransmitters analyses.Key Results: We found that PA decreased visceral sensitivity, diarrhea symptoms and intestinal transit in the IBS-D rats. Meanwhile, 10 and 20 mg/kg of PA significantly reduced the proportion of excitatory LMMP neurons in the distal colon, decreased the number of acetylcholine (Ach)- and substance P (SP)-positive neurons in the distal colon and restored the levels of Ach and SP in the IBS-D rats.Conclusion and Implications: These findings indicated that PA modulated LMMP excitatory neuron activities, improved intestinal motility and alleviated IBS-induced diarrheal symptoms, suggesting the potential therapeutic efficacy of PA against IBS-D

Pretargeted Radioimmunotherapy Using Genetically Engineered Antibody-Streptavidin Fusion Proteins for Treatment of Non-Hodgkin Lymphoma

Pretargeted radioimmunotherapy (PRIT) using streptavidin (SAv)-biotin technology can deliver higher therapeutic doses of radioactivity to tumors than conventional RIT. However, “endogenous” biotin can interfere with the effectiveness of this approach by blocking binding of radiolabeled biotin to SAv. We engineered a series of SAv FPs that down-modulate the affinity of SAv for biotin, while retaining high avidity for divalent DOTA-bis-biotin to circumvent this problem

Data-driven Convexification for Frequency Nadir Constraint of Unit Commitment

The increasing penetration of the renewable energy sources brings new challenges to the frequency security of power systems. In order to guarantee the system frequency security, frequency constraints are incorporated into unit commitment (UC) models. Due to the non-convex form of the frequency nadir constraint which makes the frequency constrained UC (FCUC) intractable, this letter proposes a revised support vector machine (SVM) based system parameter separating plane method to convexify it. Based on this data-driven convexification method, we obtain a tractable FCUC model which is formulated as a mixed-integer quadratic programming (MIQP) problem. Case studies indicate that the proposed method can obtain less conservative solution than the existing methods with higher efficiency

Properties comparison of high density polyethylene composites filled with three kinds of shell fibers

The extrusion method was applied to prepare composites with peanut husk, rice husk and walnut shell based on high density polyethylene (HDPE) and the properties of the three composites were compared and analyzed in this study. It was found that the rice husk/HDPE composite has the best mechanical strength and creep resistance compared with peanut husk/HDPE composite and walnut shell/HDPE composite. Moreover, the basic characterization of the three composite showed that the bonding interface of rice husk/HDPE composite was the smoothest and the most uniform compared with peanut husk/HDPE composite and walnut shell/HDPE composite. Although the fiber content had an important effect on the diffraction peak intensity of the composites, it did not change the microcrystalline structure of the three composites. Keywords: Shell fibers, HDPE, Composites, Properties compariso