Design of an intelligent telephone/fax switch box

While fax machines have been widely used in businesses since the early 1980's, it was only in the last decade or so that they began to proliferate homes and SOHOs (small office / home office). This can be attributed to the increasing number of fax manufacturers resulting in intense competition and a steep drop in prices.Master of Science (Consumer Electronics

Electronic Commerce in Singapore.

The objective of this project is to gain an overview and understanding of electronic commerce in Singapore. The Internet is poised to become an important business channel in the 21 st century. Internet electronic commerce is predicted to have exponential growth in the future and will have a significant impact on the way business is conducted. An understanding of the developments and uses of electronic commerce is essential for all business professionals

How globalisation affects Singapore's unit labour costs in the manufacturing sector

Given the scale of how globalisation has transformed our industries, it was imperative for us to explore if success in interconnected markets rely solely on sustaining low unit labour costs (ULC). While low ULCs are conventionally equated with constrained wage growth for workers and high labour productivities, we conducted a novel estimation study that encompasses ULC's primary determinants - real remuneration growth, capital intensity growth and total factor productivity (TFP) growth - in assessing cost competitiveness. Our findings of Singapore's manufacturing sector up to the two-digit level revealed that cost competitiveness can be maintained if increases in real wages are offset by proportionate increases in capital intensity and TFP. The results reaffirm the conclusions of Ordóñez and his colleagues (2015) and provide empirical evidence for Singapore's on-going effort to restructure her economy. Hence, an economy primarily needs to be manpower-lean, more capital-intensive and foster high TFP growth to compete more effectively

Sustained activation of non-canonical NF-κB signalling drives glycolytic reprogramming in doxorubicin-resistant DLBCL

DLBCL is the most common lymphoma with high tumor heterogeneity. Treatment refractoriness and relapse from R-CHOP therapy in patients remain a clinical problem. Activation of the non-canonical NF-κB pathway is associated with R-CHOP resistance. However, downstream targets of non-canonical NF-κB mediating R-CHOP-induced resistance remains uncharacterized. Here, we identify the common mechanisms underlying both intrinsic and acquired resistance that are induced by doxorubicin, the main cytotoxic component of R-CHOP. We performed global transcriptomic analysis of (1) a panel of resistant versus sensitive and (2) isogenic acquired doxorubicin-resistant DLBCL cell lines following short and chronic exposure to doxorubicin respectively. Doxorubicin-induced stress in resistant cells activates a distinct transcriptional signature that is enriched in metabolic reprogramming and oncogenic signalling. Selective and sustained activation of non-canonical NF-κB signalling in these resistant cells exacerbated their survival by augmenting glycolysis. In response to doxorubicin, p52-RelB complexes transcriptionally activated multiple glycolytic regulators with prognostic significance through increased recruitment at their gene promoters. Targeting p52-RelB and their targets in resistant cells increased doxorubicin sensitivity in vitro and in vivo. Collectively, our study uncovered novel molecular drivers of doxorubicin-induced resistance that are regulated by non-canonical NF-κB pathway. We reveal new avenues of therapeutic targeting for R-CHOP-treated refractory/relapsed DLBCL patients.Nanyang Technological UniversityNational Medical Research Council (NMRC)National Research Foundation (NRF)Submitted/Accepted versionThis study is funded by the National Research Foundation (NRF) Singapore, under its Singapore NRF Fellowship (NRFNRFF2018-04). In addition, we thank the Nanyang Assistant Professorship (NAP) Startup-grant to Y.L. lab and National Medical Research Council (NMRC-OFLCG18May0028), Tanoto Foundation and Ling Foundation for their support