Descripción de la cadena global de valor de la industria automotriz: actores, actividades e impactos en la sustentabilidad reportados

Fil: Amato, Celina Noé. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.El enfoque de cadenas globales de valor [CGV] es de utilidad paraanalizar las empresas de países en desarrollo que se insertan en las cadenas globalescomo proveedoras de insumos y partes, y que deben adaptarse a los criterios desustentabilidad impuestos por las empresas líderes. Una de las formas actuales quelas empresas han incorporado para la comunicación de sus prácticas sociales yambientales, son los llamados informes o reportes de sustentabilidad.publishedVersionFil: Amato, Celina Noé. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Negocios y Administració

Descripción de la cadena global de valor de la industria automotriz: actores, actividades e impactos en la sustentabilidad reportados

Fil: Amato, Celina Noé. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Fil: Berrino, Liliana Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Fil: Cohen, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Fil: Pereyra, Walter Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Fil: Romero, Mariano Andrés. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.El presente trabajo forma parte de un proyecto de investigación en curso titulado "Contexto institucional y conflictos de intereses como condicionantes del upgrading sustentable en cadenas globales de valor argentinas", por lo que aquí se exponen los avances en una de las cadenas de valor analizadas y en uno de los objetivos específicos de dicho proyecto. Dicho avance se concentra en la cadena global de valor [CGV] de la industria automotriz, en un intento de realizar una descripción de su configuración a nivel global, regional y local, para luego definir su estructura y los principales impactos en la sustentabilidad informados.Fil: Amato, Celina Noé. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Fil: Berrino, Liliana Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Fil: Cohen, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Fil: Pereyra, Walter Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Fil: Romero, Mariano Andrés. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Administración; Argentina.Negocios y Administració

Efficacy of albendazole in the treatment of enterobiasis

Albendazole was shown to be very effective in the treatment of enterobiasis. A cure rate of 100% was noticed, when a single dose of 10 mg/kg was given to 29 children. The drug was quite well tolerated by all recipients. This trial has brought additional evidence of the efficacy of albendazole as an antihelminthic agent, contributing to the proper establishment of its spectrum of activity.Verificaram os Autores que o albendazol é muito eficiente no tratamento da enterobíase. Usando dose única de 10 mg/kg, obtiveram 100% de curas quando administraram esse anti-helmíntico a 29 crianças. Foi comprovada tolerância bastante satisfatória e o estudo realizado contribuiu para a melhor demarcação do espectro de atividade antiparasitária do composto referido

Pesquisa de ovos de helmintos e de cistos de protozoários em dinheiro

Due to the high prevalence of intestinal parasitic diseases in Brazil and to the fact that inanimate objects may play an important role in their transmission, it was decided to carry out an investigation into the existence of helminthic eggs and protozoan cysts in money currently handled by the community. A thousand and three banknotes and 1,011 coins of different origins were analysed, yielding the following results. Entamoeba histolytica cysts were found twice, and fertile and infertile Ascaris lumbricoides eggs and one intact Taenia sp. egg, besides other nonpathogenic elements, were also found. The importance of the handling of money in the epidemiology of common intestinal parasitic diseases is emphasized and it is suggested that further similar studies should be carried out; possible means of prevention are also indicated.Em virtude da elevada prevalência de parasitoses intestinais no Brasil e da possível participação de objetos na transmissão dessas afecções, foi desenvolvida pesquisa envolvendo dinheiro difundido na coletividade. Foram analisadas, quanto à presença de ovos de helmintos e de cistos de protozoários, 1.003 cédulas e 1.011 moedas, de valores e procedências diversos. Do estudo resultou o encontro de cistos de Entamoeba histolytica em duas eventualidades, de ovos de Ascaris lumbricoides larvado e infértil, de ovo de Taenia sp. morfologicamente íntegro e de outros elementos não patogênicos. Ficou salientada a importância do dinheiro circulante na epidemiologia das enteroparasitoses, tendo havido sugestão de novos trabalhos de natureza congênere, inclusive delineando diretrizes de ordem profilática

Evaluation of the activity of albendazole in the therapy of experimentally-infected rats

In order to settle the precise spectrum of activity of albendazole, its efficacy was tested in the treatment of Strongyloides venezuelensis in experimentally-infected rats. The results were compared to those obtained with two other benzimidaloze derivatives, cambendazole and mebendazole. The three compounds were shown to be effective in eradicating intestinal adult worms completely, when single doses of 625, 12.5, 25 of 50 mg/kg were used. However when smaller doses were employed (5 mg/kg) worm burdens were reduced in 87%, 98% and 80% by albendazole, cambendazole and mebendazole respectively.Com a finalidade de demarcar mais precisamente o espectro de ação do albendazol, foi estudada a atividade terapêutica desse anti-helmíntico em ratos experimentalmente infectados com Strongyloides venezuelensis, tendo sido usada, como termo de comparação, a ação do cambendazol e do mebendazol, dois outros benzimidazólicos. Os três compostos mostraram-se eficientes quando utilizadas doses únicas de 6,75, 12,5, 25 e 50 mg/kg, pois motivaram desaparecimento total das formas adultas no intestino. Com a posologia de 5 mg/kg sucederam porcentagens médias de reduções dos números de vermes de 87%, 98% e 80%, respectivamente, como decorrência do emprego do albendazol, do cambendazol e do mebendazol, traduzindo superioridade da segunda droga citada

Avaliação da atividade terapêutica do albendazol em ratos experimentalmente infectados com Strongyloides venezuelensis

Com a finalidade de demarcar mais precisamente o espectro de ação do albendazol, foi estudada a atividade terapêutica desse anti-helmíntico em ratos experimentalmente infectados com Strongyloides venezuelensis, tendo sido usada, como termo de comparação, a ação do cambendazol e do mebendazol, dois outros benzimidazólicos. Os três compostos mostraram-se eficientes quando utilizadas doses únicas de 6,75, 12,5, 25 e 50 mg/kg, pois motivaram desaparecimento total das formas adultas no intestino. Com a posologia de 5 mg/kg sucederam porcentagens médias de reduções dos números de vermes de 87%, 98% e 80%, respectivamente, como decorrência do emprego do albendazol, do cambendazol e do mebendazol, traduzindo superioridade da segunda droga citada.In order to settle the precise spectrum of activity of albendazole, its efficacy was tested in the treatment of Strongyloides venezuelensis in experimentally-infected rats. The results were compared to those obtained with two other benzimidaloze derivatives, cambendazole and mebendazole. The three compounds were shown to be effective in eradicating intestinal adult worms completely, when single doses of 625, 12.5, 25 of 50 mg/kg were used. However when smaller doses were employed (5 mg/kg) worm burdens were reduced in 87%, 98% and 80% by albendazole, cambendazole and mebendazole respectively

Long-term disability trajectories in relapsing multiple sclerosis patients treated with early intensive or escalation treatment strategies

Background and aims: No consensus exists on how aggressively to treat relapsing-remitting multiple sclerosis (RRMS) nor on the timing of the treatment. The objective of this study was to evaluate disability trajectories in RRMS patients treated with an early intensive treatment (EIT) or with a moderate-efficacy treatment followed by escalation to higher-efficacy disease modifying therapy (ESC). Methods: RRMS patients with ⩾5-year follow-up and ⩾3 visits after disease modifying therapy (DMT) start were selected from the Italian MS Registry. EIT group included patients who received as first DMT fingolimod, natalizumab, mitoxantrone, alemtuzumab, ocrelizumab, cladribine. ESC group patients received the high efficacy DMT after ⩾1 year of glatiramer acetate, interferons, azathioprine, teriflunomide or dimethylfumarate treatment. Patients were 1:1 propensity score (PS) matched for characteristics at the first DMT. The disability trajectories were evaluated by applying a longitudinal model for repeated measures. The effect of early versus late start of high-efficacy DMT was assessed by the mean annual Expanded Disability Status Scale (EDSS) changes compared with baseline values (delta-EDSS) in EIT and ESC groups. Results: The study cohort included 2702 RRMS patients. The PS matching procedure produced 363 pairs, followed for a median (interquartile range) of 8.5 (6.5-11.7) years. Mean annual delta-EDSS values were all significantly (p < 0.02) higher in the ESC group compared with the EIT group. In particular, the mean delta-EDSS differences between the two groups tended to increase from 0.1 (0.01-0.19, p = 0.03) at 1 year to 0.30 (0.07-0.53, p = 0.009) at 5 years and to 0.67 (0.31-1.03, p = 0.0003) at 10 years. Conclusion: Our results indicate that EIT strategy is more effective than ESC strategy in controlling disability progression over time