Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported. Using an ultrasensitive and specific protein misfolding cyclic amplification–based assay for detecting variant CJD prions in cerebrospinal fluid, we discriminated this heterozygous case of variant CJD from cases of sporadic CJD

Prion amplification techniques for the rapid evaluation of surface decontamination procedures.

International audienc

Prion amplification techniques for the rapid evaluation of surface decontamination procedures.

International audienc

Earliest detection of prion seeding activity in blood of human PRP transgenic mice infected with vCJD

International audienc

Diagnosis of Variant Creutzfeldt - Jakob Disease in life Using Protein Misfolding Cyclic Amplification (PMCA).

International audienc

Diagnosis of Variant Creutzfeldt - Jakob Disease in life Using Protein Misfolding Cyclic Amplification (PMCA).

International audienc

Earliest detection of prion seeding activity in blood of human PRP transgenic mice infected with vCJD

International audienc

Diagnosis of Methionine/Valine Variant Creutzfeldt - Jakob disease using PMCA in Cerebrospinal fluid.

International audienc

Diagnosis of Methionine/Valine Variant Creutzfeldt - Jakob disease using PMCA in Cerebrospinal fluid.

International audienc

Diagnosis of Methionine/Valine Variant Creutzfeldt - Jakob disease using PMCA in Cerebrospinal fluid

International audienc