Synthetic studies towards bioactive frondosins: rapid framework access and diversity creation

A very concise and diversity-oriented approach to rapidly access frondosin-related frameworks from commercially available building blocks is outlined

A total synthesis of (+/-)-frondosins A and B

A total synthesis of the bioactive meroterpenoid natural products frondosin B and frondosin A (formal) from readily available cyclohexanone and gentisic aldehyde dimethyl ether, involving RCM as the key step to generate the bicyclic 6,7-fused core structure, is Outlined

Synthetic studies towards bioactive frondosins: rapid framework access and diversity creation

A very concise and diversity-oriented approach to rapidly access frondosin-related frameworks from commercially available building blocks is outlined

A concise synthesis of the bioactive meroterpenoid natural product (±)-liphagal, a potent PI3k inhibitor

A short, diversity-oriented synthesis that follows a biomimetic route to the marine natural product liphagal, from a commercially available building block, is delineated

A concise synthesis of the bioactive meroterpenoid natural product (+/-)-liphagal, a potent PI3K inhibitor

A short, diversity-oriented synthesis that follows a biomimetic route to the marine natural product liphagal, from a commercially available building block, is delineated