The genotype distributions of TLR9-1486 T/C in cases and controls.

a<p>Adjusted for age, sex, and <i>H. pylori</i> infection.</p><p>OR, odds ratio; CI, confidence interval.</p

Baseline characteristics of cases and controls.

<p>TNM: Tumor, Lymph Node, Metastasis.</p><p>Among 314 patients, 53 have missing TNM stage data.</p

Association between TLR9 -1486 T/C and gastric carcinoma in relation to <i>H. pylori</i> infection.

*<p>Adjusted for age and sex.</p

Stratified analyses between TLR9 -1486 T/C polymorphisms and gastric cancer risk.

*<p>Adjusted for age, sex, and <i>H. pylori</i> infection in a logistic dominant model.</p><p>OR, odds ratio; CI, confidence interval.</p

Regions showing differences in activation between the preferential choice task and the judgment-based choice task.

<p>Regions showing differences in activation between the preferential choice task and the judgment-based choice task.</p

Construction of pSPI12-cured <i>Salmonella enterica</i> serovar Pullorum and identification of IpaJ as an immune response modulator

<p>In <i>Salmonella</i>, plasmids participate in many pathways involved in virulence, metabolism, and antibiotic resistance. To investigate the function of the <i>ipaJ</i> gene in a multi-copy plasmid pSPI12 prevalent in <i>Salmonella enterica</i> serovar Pullorum (<i>S</i>. Pullorum), we established a method to eliminate the plasmid and constructed the plasmid-cured bacteria C79-13-ΔpSPI12 by using the suicide vector pDM4. Briefly, a 500 bp fragment <i>ipaJU</i> from pSPI12 was cloned into pDM4 and transformed into <i>S.</i> Pullorum C79-13 by conjugative transfer. After homologous recombination, the suicide vector was inserted into pSPI12 to produce pSPI12-pDM4-<i>ipaJU</i>. Induction of the expression of the <i>sacB</i> gene in the suicide vector killed the bacteria harbouring plasmid, while the progeny losing the plasmid survived in the plate with sucrose. The plasmid-cured strain showed extremely decreased ability to infect chicken macrophage HD11 cells and LMH hepatic epithelial cells compared to wild type strain and complementary strain carrying <i>ipaJ</i>. Additionally, IFN-<i>γ</i> mRNA levels were up-regulated in HD11 cells or chicken spleens infected by plasmid-cured strain, but no difference was detected in IL-4 among the three strains. Transforming <i>ipaJ</i> into <i>S.</i> Enteritidis also decreased expression of proinflammatory cytokines in infected macrophages or chicken spleens compared to wild type strain. These results suggest that the <i>ipaJ</i> gene in pSPI12 is involved in <i>S.</i> Pullorum infection and that IpaJ protein modulates immune response.</p

Brain regions tracking variations in decision parameters.

<p>MPFC showed differences in sensitivity to the intradimensional difference in the probability dimension in Model I (A), in sensitivity to the unidimensional difference in Model I (B), and in sensitivity to the intradimensional difference in the payoff dimension in Model II (C). In the left column, the region was displayed in a T1-weighted MRI template. In the right column, the mean parameter estimates of the corresponding region in the two choice tasks were shown.</p

Regional sensitivity to the intradimensional difference in the payoff dimension and regional sensitivity to the unidimensional difference within each task.

<p>*Two clusters located in the left MPFC survived the height but not the extent threshold.</p

Task trial structure.

<p>A. Trial types. B. Trial timing. Two bets were presented and the participants' task was to indicate their decision by pressing one of two buttons on a response pad.</p

Regions sensitive to the intradimensional difference in the probability dimension and regional sensitivity to the unidimensional difference within each task.

<p>Regions sensitive to the intradimensional difference in the probability dimension and regional sensitivity to the unidimensional difference within each task.</p