Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo

Tremendous progress in synthetic micro/nanomotors has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient for deep tissue imaging and motion control in vivo. Here, we present a photoacoustic computed tomography (PACT) guided investigation of micromotors in intestines in vivo. The micromotors enveloped in microcapsules exhibit efficient propulsion in various biofluids once released. PACT has visualized the migration of micromotor capsules toward the targeted regions in real time in vivo. The integration of the developed microrobotic system and PACT enables deep imaging and precise control of the micromotors in vivo

CORRELATION BETWEEN WATER QUALITY AND Chl.a OF PHYTOPLANKTON AND THE COUNTERMEASURES FOR INHIBITING ALGAL GROWTH IN WEST LAKE, HANGZHOU

On the basis of the analysis of chlorophyll-a and physicochemical factors in the water of West Lake, the results show that algal growth in Lake Beili, Lake Yue, Lake Xili and Lake Wai is affected mainly by water temperature, and is not limited by the high concentrations of N and P in the water. The water quality in L.Xiaonan is better than that in other lake areas, because it lies at the diversion entrance and is directly influenced by drawing water from Qiantang River. Studies on biological control experiments suggested that a reasonable and coordinated ecological system would be more beneficial to the water quality than the other countermeasures.Article信州大学理学部附属諏訪臨湖実験所報告 11: 29-34(1999)departmental bulletin pape

Intracellular Signaling Molecules Activated by Epstein-Barr Virus for Induction of Interferon Regulatory Factor 7

Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) is the principal oncogenic protein in the EBV transformation process. LMP-1 induces the expression of interferon regulatory factor 7 (IRF-7) and activates IRF-7 protein by phosphorylation and nuclear translocation. LMP-1 is an integral membrane protein with two regions in its C terminus that initiate signaling processes, the C-terminal activator regions 1 (CTAR-1) and CTAR-2. Here, genetic analysis of LMP-1 has determined that the PXQXT motif that governs the interaction between LMP-1 CTAR-1 and tumor necrosis factor receptor-associated factors (TRAFs) is needed to induce the expression of IRF-7. Mutations in the PXQXT motif in CTAR-1 that disrupt the interaction between LMP-1 and TRAFs abolished the induction of IRF-7. Also, dominant-negative mutants of TRAFs inhibited the induction of IRF-7 by CTAR-1. The last three amino acids (YYD) of CTAR-2 are also important for the induction of IRF-7. When both PXQXT and YYD were mutated (LMP-DM), the LMP-1 mutant failed to induce IRF-7. Also, LMP-DM blocked the induction of IRF-7 by wild-type LMP-1. These data strongly suggest that both CTAR-1 and CTAR-2 of LMP-1 independently induce the expression of IRF-7. In addition, NF-_B is involved in the induction of IRF-7. A superrepressor of I_B (sr-I_B) could block the induction of IRF-7 by LMP-1, and overexpression of NF-_B (p65 plus p50) could induce the expression of IRF-7. In addition, we have found that human IRF-7 is a stable protein, and sodium butyrate, a modifier of chromatin structure, induces IRF-7

STUDY ON THE CORRELATION OF WATER QUALITY FACTORS WITH SPECIES DISTRIBUTION OF MANGANESE IN WEST LAKE

In this paper, changes in water quality factors of West Lake and variations in the speciation distribution of Manganese in both water and bottom sediment from June 1995 to May 1996 was reported. The correlation of manganese species distribution with water quality factors was also investigated. The results showed that besides TP, T, TIN, and chl-a etc., Manganese was also one of the main factors which affects water transparency.Article信州大学理学部附属諏訪臨湖実験所報告 11: 73-77(1999)departmental bulletin pape

DYNAMIC VARIATION OF WATER QUALITY IN WEST LAKE AND MULTIVARIATE ANALYSIS OF ITS PRIMARY FACTORS

Dynamic variation of water quality in West Lake is analyzed based on the data of 1995. Principal Component Analysis is used to reveal the mutual relationships of various factors. It is shown that there exists an obvious special and temporal variation in the main factors of water quality. Annual values of TP, TN, and Chl.a fluctuate seasonally. In addition, Chl.a has a synchronous variation with water temperature, although being lagged a little, and closely relates to TP and TN. SD has a good negative relation with Chl.a. The results from Principal Component Analysis show that SD, Ec, Tw, pH and Chl.a are the most influential factors in water quality of the West Lake.Article信州大学理学部附属諏訪臨湖実験所報告 11: 21-27(1999)departmental bulletin pape