104 research outputs found
The Predictive Role of Materialistic Values on Learning Burnout by Pre-service Teachers: A Parallel Channel Model
This study set out to explore the relationship between materialistic values (MVS), ontological security threat (OST), gratitude, and learning burnout (LB) among pre-service teachers enrolled in the Free Teacher Education program in China. MVS, adolescent student burnout, gratitude, and OST questionnaires were administered to 801 pre-service teachers. Data processing was conducted using IBM SPSS 26.0 and AMOS 24.0. The SPSS macro program Model 4 was used to identify mediating mechanisms. Study findings were as follows: (1) MVS was positively correlated with both OST and LB, but negatively correlated with gratitude. (2) OST was positively correlated with LB, while gratitude was negatively correlated with LB. (3) The impact of MVS on pre-service teachers' LB was simultaneously mediated by OST and gratitude. MVS not only directly predicts pre-service teachers' LB, but also influences LB through the independent mediators of OST and gratitude
Fourier ptychographic reconstruction using Poisson maximum likelihood and truncated Wirtinger gradient
Fourier ptychographic microscopy (FPM) is a novel computational coherent
imaging technique for high space-bandwidth product imaging. Mathematically,
Fourier ptychographic (FP) reconstruction can be implemented as a phase
retrieval optimization process, in which we only obtain low resolution
intensity images corresponding to the sub-bands of the sample's high resolution
(HR) spatial spectrum, and aim to retrieve the complex HR spectrum. In real
setups, the measurements always suffer from various degenerations such as
Gaussian noise, Poisson noise, speckle noise and pupil location error, which
would largely degrade the reconstruction. To efficiently address these
degenerations, we propose a novel FP reconstruction method under a gradient
descent optimization framework in this paper. The technique utilizes Poisson
maximum likelihood for better signal modeling, and truncated Wirtinger gradient
for error removal. Results on both simulated data and real data captured using
our laser FPM setup show that the proposed method outperforms other
state-of-the-art algorithms. Also, we have released our source code for
non-commercial use
Motion-corrected Fourier ptychography
Fourier ptychography (FP) is a recently proposed computational imaging
technique for high space-bandwidth product imaging. In real setups such as
endoscope and transmission electron microscope, the common sample motion
largely degrades the FP reconstruction and limits its practicability. In this
paper, we propose a novel FP reconstruction method to efficiently correct for
unknown sample motion. Specifically, we adaptively update the sample's Fourier
spectrum from low spatial-frequency regions towards high spatial-frequency
ones, with an additional motion recovery and phase-offset compensation
procedure for each sub-spectrum. Benefiting from the phase retrieval redundancy
theory, the required large overlap between adjacent sub-spectra offers an
accurate guide for successful motion recovery. Experimental results on both
simulated data and real captured data show that the proposed method can correct
for unknown sample motion with its standard deviation being up to 10% of the
field-of-view scale. We have released our source code for non-commercial use,
and it may find wide applications in related FP platforms such as endoscopy and
transmission electron microscopy
PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.
Necroptosis, a form of regulated necrotic cell death, is governed by RIP1/RIP3-mediated activation of MLKL. However, the signaling process leading to necroptotic death remains to be elucidated. In this study, we found that PUMA, a proapoptotic BH3-only Bcl-2 family member, is transcriptionally activated in an RIP3/MLKL-dependent manner following induction of necroptosis. The induction of PUMA, which is mediated by autocrine TNF-α and enhanced NF-κB activity, contributes to necroptotic death in RIP3-expressing cells with caspases inhibited. On induction, PUMA promotes the cytosolic release of mitochondrial DNA and activation of the DNA sensors DAI/Zbp1 and STING, leading to enhanced RIP3 and MLKL phosphorylation in a positive feedback loop. Furthermore, deletion of PUMA partially rescues necroptosis-mediated developmental defects in FADD-deficient embryos. Collectively, our results reveal a signal amplification mechanism mediated by PUMA and cytosolic DNA sensors that is involved in TNF-driven necroptotic death in vitro and in vivo
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