La sécrétion gastrique d'acide de pepsine et d'ions en clinique humaine. Théories sécrétoires et aspects physio-pathologiques

info:eu-repo/semantics/nonPublishe

A PROPOS DES RISQUES ALPHA ET BETA DANS LA COMPARAISON DE DEUX MOYENNES OU COMMENT LE DROIT A LA DIFFERENCE PEUT SE CACHER A L'OMBRE DU DOUTE

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Sensibilité et spécificité de l'amylasemie, du rapport des clairances d'amylase et de créatinine et du rapport amylasurie/creatininurie pour le diagnostic des pancréatites aigues

The sensitivity and specificity of amylasemia, the ratios of amylase/creatinine clearance and amylasuria/creatininuria were determined in four groups of patients: a control group (n = 43), patients with acute pancreatitis detected on computed tomography (n = 30, 25 cases of alcoholic pancreatitis), patients with an acute surgical abdomen without pancreatitis (n = 25), and patients with renal failure (n = 20). Sensitivity was defined for the acute pancreatitis group and specificity for the other groups. When amylasemia was > 20 UI/dl and the amylasuria/creatininuria ratio > 100, sensitivity was 98 per cent. The specificity of these two results in patients with an acute surgical abdomen was 98 pe cent. When the ratio amylase/creatinine clearance ratio was > 4 sensitivity was 73 per cent and specificity in patients with acute surgical abdomen was 75 per cent. These two values were lower than those of the two preceeding tests (p 4 was 73 per cent. The amylase/creatinine clearance ratio did not seem to be reliable since its change was delayed with respect to the increase of amylasemia and amylasuria. This ratio has a poor specificity as it increased when the clearance of creatinine decreased in the group with an acute surgical abdomen associated with functional or organic renal failure. In these two groups, the correlation between the amylase/creatinine clearance ratio and creatininemia was significant. This suggested that the clearance of creatinine fell more rapidly than the clearance of amylase as renal failure increased.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

CONCENTRATIONS BASALES ET DEBITS INTEGRES POST-PRANDIAUX DE GASTRIENE CHEZ DES MALADES ATTEINTS DE GASTRITE ATROPHIQUE OU D'ULCERE DUODENAL. LIMITES A L'UTILITE DIAGNOSTIQUE

Maximal acid outputs were determined during intravenous pentagastrin tests (6 μg/kg/h) in 119 male subjects: 17 controls, 74 patients with duodenal ulcer and 28 with atrophic gastritis. Basal and postprandial serum gastrin levels were also determined in order to estimate the integrated gastrin response to the meal. In patients with atrophic gastritis the maximal acid output was decreased (p < 0.01) and the integrated gastric response was increased (p < 0.01) but the basal gastrin levels in these patients did not differ from that of controls. An integrated gastrin response greater than 2.5 ng/ml/100 min was observed in 89% of patients with atrophic gastritis. An integrated gastrin response smaller than 2.5 ng/ml/100 min was observed in 76% of controls. The maximal acid output was smaller than 20 mmol/l in all patients with atrophic gastritis but was greater than this value in all controls. In duodenal ulcer patients, the measured parameters were not significantly different from control values. The measure of the integrated gastrin response which reflects the presence of antral endocrine hyperactivity may be useful to detect patients with atrophic gastritis, but this test is less sensitive and less specific than the determination of the maximal acid output.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Lymphangiectasies et entéropathie exsudative

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Influence de la consommation de cigarettes sur la cicatrisation de l'ulcere duodenal chez des malades traites par la cimetidine. Role de l'hypersecretion acide

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Lymphangiectasies et entéropathie exsudative

The authors report the case of a 56 yr old man suffering from oedema of the inferior limbs. This oedema was secondary to a protein-loosing enteropathy of lymphatic origin. Histological examination revealed intestinal lymphangiectasia. After reviewing all the cases of secondary intestinal lymphangiectasia, the diagnosis of primary lymphangiectasia was proposed. Middle chain triglycerides administration induced clinical and biological improvement.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

EFFET DE 300 MG DE RANITIDINE, DE 800 MG DE CIMETIDINE ET D'UN PLACEBO ADMINISTRES APRES LE REPAS DU SOIR SUR LE pH GASTRIQUE DE 24 HEURES CHEZ L'ULCEREUX DUODENAL

Twenty-four-hour intragastric pH monitoring was performed in 20 patients with duodenal ulcer in order to compare the results obtained with placebo, ranitidine 300 mg and cimetidine 800 mg administered one hour (7 PM) after evening meal (6 PM). During each 24 h period (8 AM-8 AM), gastric pH was continuously monitored in standardized dietary conditions. Treatment was started the evening (7 PM) before the test. Median acidity was calculated and percent of time of recording at or above any pH unit was graphically represented. Median acidity and areas under the curves were submitted to statistical comparison. The values were computed for the 24-h period, for the 8 AM-8 PM period, for the 8 PM-8 AM period. In these three periods studied gastric acidity decreased more with ranitidine than with cimetidine. No statistical difference was found between cimetidine and placebo for the 8 AM-8 PM period.SCOPUS: re.jinfo:eu-repo/semantics/publishe

COMPARAISON DU PH GASTRIQUE DE 24 HEURES CHEZ DES TEMOINS, DES ULCEREUX DUODENAUX ET DES MALADES ATTEINTS DE GASTRITE ATROPHIQUE

Twenty-four intragastric acidity was measured by continuous recording using intragastric glass electrodes in 16 normal controls, 18 inactive duodenal ulcer patients and 7 patients with atrophic gastritis. Median pH for the 24 h period, for the 8 AM-8 PM period, and for the 8 PM-8 AM period were significantly lower in duodenal ulcer patients than in controls (1.19 vs. 1.78; 1.17 vs 2.05; 1.27 vs 1.64). Median pH for these 3 periods were significantly higher in patients with atrophic gastritis than in controls (3.90; 3.72; 3.81). The median pH for the 24 h period was higher than the lower quartile value of the control group in 33 per cent of duodenal ulcer patients. During the night (24 h-3 h), duodenal ulcer patients had significantly lower median pH (1.03) than controls (1.51). Antisecretory treatment should be directed to decrease this period of unbuffered acidity.SCOPUS: ar.jinfo:eu-repo/semantics/publishe