Phenotypic and functional characterisation of cervical and peripheral HIV-1 specific T cell responses

Includes bibliographical references (leaves 92-109).Distinct HIV variants occur at the genital mucosa compared to in blood, which may similarly result in differences in HIV T cell responses. There have been no studies of the maturational status of HIV-specific T cells present at the female genital mucosa. This study aimed to characterise HIV-specific cervical immune responses and to determine if compartmentalized immune responses occur in chronic HIV infection by comparing the characteristics of T cells at the cervical mucosa to those in blood

Bugs, drugs, and HIV : the role of the vaginal microbiome in HIV risk and antiretroviral efficacy for HIV prevention.

CAPRISA, 2017.Abstract available in pdf

Randomized cross-sectional study to compare HIV-1 specific antibody and cytokine concentrations in female genital secretions obtained by menstrual cup and cervicovaginal lavage.

CAPRISA, 2015.Abstract available in pdf

Genital—systemic chemokine gradients and the risk of HIV acquisition in women.

CAPRISA, 2017.Abstract available in pdf

Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.

CAPRISA, 2016.Abstract available in pdf

Distinct genital tract HIV-specific antibody profiles associated with Tenofovir gel.

CAPRISA, 2016.Abstract available in PDF file