General characteristics of the study population at baseline and follow-up.

<p>Differences between baseline and follow-up are tested for statistical differences: paired t-test for continuous variables, McNemar’s paired chi squared test for binary outcomes. The number of persons included in each analysis depends on the source of the outcome data: questionnaire (n = 234), lung function (n = 161), or serological data (n = 212).</p

Changes in reported health symptoms and IgE positivity between baseline and follow-up.

<p>Participants are categorized as never (absent at baseline and follow-up), new onset (negative at baseline and positive at follow up), loss (positive at baseline and negative at follow up) and persistent (positive both at baseline and follow up) health symptoms.</p

General characteristics of the study population at baseline and follow-up.

<p>Differences between baseline and follow-up are tested for statistical differences: paired t-test for continuous variables, McNemar’s paired chi squared test for binary outcomes. The number of persons included in each analysis depends on the source of the outcome data: questionnaire (n = 234), lung function (n = 161), or serological data (n = 212).</p

Odds of loss, new onset and persistence of allergic outcomes during follow-up in association with endotoxin exposure.

<p>Analyses are adjusted for potential confounders (age, gender, smoking and farm childhood). A consistent protective pattern is observed for hay fever, grass IgE sensitization and atopy, although not all associations meet statistical significance.</p

Multivariate kernel analyses.

<p>Multivariate kernel analyses.</p

Descriptive statistics of the spatial, temporal and spatial-temporal characteristics.

<p>Descriptive statistics of the spatial, temporal and spatial-temporal characteristics.</p

Overview of monthly averaged outdoor temperature and pattern of kidding season (estimated monthly percentages of goats born in the Netherlands based on the paper of Hermans et al [22]).

<p>Overview of monthly averaged outdoor temperature and pattern of kidding season (estimated monthly percentages of goats born in the Netherlands based on the paper of Hermans et al [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151281#pone.0151281.ref022" target="_blank">22</a>]).</p

Percentage of positive samples for <i>C</i>. <i>burnetii</i> DNA per week from March–September 2011.

<p>Percentage of positive samples for <i>C</i>. <i>burnetii</i> DNA per week from March–September 2011.</p

Significant temporal and spatial associations to the presence of <i>C</i>. <i>burnetii</i> in PM10, mutually adjusted in the multivariable model.

<p>Significant temporal and spatial associations to the presence of <i>C</i>. <i>burnetii</i> in PM10, mutually adjusted in the multivariable model.</p

Univariable associations between the presence of <i>C</i>. <i>burnetii</i> in PM10 and spatial, temporal and spatial-temporal characteristics.

<p>Univariable associations between the presence of <i>C</i>. <i>burnetii</i> in PM10 and spatial, temporal and spatial-temporal characteristics.</p