Preface

Preface to the issue as Guest Edito

Iridium-mediated Bond Activation and Water Oxidation as an Exemplary Case of CARISMA, A European Network for the Development of Catalytic Routines for Small Molecule Activation

CARISMA is a currently running COST Action that pools leading European experts in computational and experimental chemistry to foster synergies for developing new catalytic processes for the transformation of abundant small molecules such as water, carbon dioxide, or ammonia into high-value chemicals and energy-relevant products. CARISMA promotes new collaborations, exchange of knowledge and skills, frontier training to young as well as established researchers, and a platform for the advancement of theoretical and experimental research in an iterative process, comprised of expertise in various connate domains including synthesis, catalysis, spectroscopy, kinetics, and computational chemistry. These interactions stimulate the discovery of new and efficient catalytic processes, illustrated in the second part of this contribution with the collaborative development of powerful iridium-based complexes for bond activation and water oxidation catalysis

alpha,alpha',alpha"-[Nitrilo-N)tris(methylene)]tris[benzenemethanolato-O](2-propanolato)titanium

The title catalyst belongs to a family of titanium complexes bearing C3-symmetric trialkanolamines ligands, which bind tightly to the Ti(IV) center in a tetradentate fashion providing very stable titanatranes. These complexes effect the enantioselective oxidation of prostereogenic sulfides in the presence of alkyl hydroperoxide

Revisiting the Hammett\u3c1Parameter for the Determination of Philicity: Nucleophilic Substitution with Inverse Charge Interaction

In oxygen transfer (OT) reactions the inversion of the \u3c1\u2005value is not representative of a change in mechanism. Substituents bonded to aromatic sulfoxides have the opposite effect on the rates of oxidation depending on whether the reaction is dominated by electrostatic or orbital-overlap effects

Metal-Ion-Binding Peptides: From Catalysis to Protein Tagging

Peptide-based ligands for metal ions (see schematic representation) have a diverse range of applications that extends from stereoselective catalysis to the sensing of proteins. The possibility to screen large libraries of ligands for the selection of the best systems and their coexpression with proteins make peptide-based ligands powerful tools for bridging the gap between chemistry and biolog