The influence of uncertainties and parameter structural dependencies in distribution system state estimation

This paper evaluates a number of uncertain parameters that affect the accuracy of distribution system state estimation, and ranks their importance using an efficient sensitivity analysis technique, Morris screening method. The influence of the uncertain parameters on state estimation performance is analysed globally and zonally. Furthermore the dependence structure between the critical variable and state estimation accuracy is analysed using copula to establish their relationship at different section of the bivariate space. The sensitivity of the critical parameter at different ranges is also studied and ranked using Morris screening methods to present the variation of state estimation performance when the critical variable is allocated at different sections within the feasible range. Accurate assessment of the importance of various uncertain parameters and the analysis of the dependence structure can inform power system operators which parameters will require the greatest levels of mitigation or increased monitoring accuracy in order to have satisfactory performance of distribution system state estimation

The north–south shift of the ridge location of the western Pacific subtropical high and its influence on the July precipitation in the Jianghuai region from 1978 to 2021

The Jianghuai region is the area between the Yangtze River and the Huai River in China and is a densely populated agriculture region therefore, the economics and human activity there are significantly affected by the precipitation changes, particularly during the summer when extreme storms and droughts normally occur. It will be helpful if the summer precipitation changes can be predicted. The monthly ERA5 atmospheric reanalysis data from 1978 to 2021 are used in this study to investigate the relationship between the ridge latitudinal location of the western Pacific subtropical high (WPSH) and the precipitation in July over the Jianghuai region. The results show that the WPSH ridge location has an important impact on the amount and spatial distribution of the precipitation in this region. When the ridge was northward, an anomalous anticyclonic circulation will appear over the western Pacific, leading to the weakening of the summer monsoon and the reduction of moisture transport from the Indian Ocean, therefore decreasing precipitation in the Jianghuai region, while the situation is opposite when the ridge was southward. The Niño 3.4 index in March and the India–Burma trough intensity index in June have significant correlations with the July WPSH ridge location, and both can be used as precursors to predict the WPSH ridge location and, therefore, the precipitation in this region

Co-sensitization and cross-reactivity of Blomia tropicalis with two Dermatophagoides species in Guangzhou, China

Around 85.50% of patients were sensitized to Der p, 85.37% of patients were sensitized to Der f, and 71.54% of patients were sensitized to Blo t. Further, 70.14% of patients were co-sensitized to Blo t, Der p, and Der f, and only seven patients were sensitized solely to Blo t. With increasing sIgE levels for Blo t, the positive rates of severe-level (class 5-6) co-sensitization to Der p or Der f significantly increased. Blo t was moderately associated with Der p and Der f, with correlation coefficients of 0.6998 and 0.6782, respectively. Der p and Der f inhibited IgE binding to Blo t more strongly than Blo t inhibited IgE binding to Der p or Der f in the patient groups CBlo t  < CDer p and CBlo t  < CDer f .Open Project of State Key Laboratory of Respiratory Disease [SKLRD-OP-201803, SKLRD-OP-201809]; Science and Technology Innovation Committee Project of Guangzhou [201831802]; Bureau of traditional Chinese Medicine Scientific Research Project of Guangdong [20192048]; National Natural Science Foundation of China [81601394, 81802076, 81871736]Open access articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Long-range prediction of the tropical cyclone frequency landfalling in China using thermocline temperature anomalies at different longitudes

The landfalls of the tropical cyclone (TC) along the coast of China have caused huge economic damages. There are approximately nine TC landfalls in China every year. It will be beneficial if the landfall frequency can be predicted in advance. Inspired by the study of Sparks and Toumi (Commun Earth Environ, 30-1-2020), six datasets, including four ocean reanalyses and two object analyses from 1993 to 2019, are employed to study the consistency in the relationship between the thermocline temperature anomalies at different longitudes and the frequency of TC landfalls along the coastal areas of China (South China, East China, and the whole of China). The thermocline temperature anomalies at different longitudes are tested in order to confirm our hypothesis that the eastward and westward transports of ocean heat from the warm pool are the causes of the significant correlations. The results show some significant correlations at various longitudes, and the temperature anomalies can predict the TC landfall frequency for several months or longer. Further study also shows the close relationship between the ocean heat transport and the sea surface temperature anomalies at the genesis locations of TC landfalls. The locations of the western Pacific subtropical high (WPSH) during high-frequency TC landfall years also show favorable spatial patterns to the TC landfall in South China and East China, respectively. In years with a high TC frequency in South China, the westward displacement of the WPSH ridge steers TC toward South China, while during high-frequency TC landfall years in East China, WPSH is located further north, and the westward extension of the ridge is in close proximity to the East China Sea

Urotensin II promotes the proliferation and secretion of vascular endothelial growth factor in rat dermal papilla cells by activating the Wnt-β-catenin signaling pathway

Introduction. Urotensin II (U II) is a kind of active peptide with a variety of biological effects, such as promoting cell proliferation and endocrine effects. The aim of this study is to investigate the effect of urotensin II on the proliferation and secretion of vascular endothelial growth factor (VEGF) in cultured rat dermal papilla cells (DPCs), and to explore its molecular mechanism. Materials and Methods. We used the DPCs isolated from the thoracic aortas of Wistar-Kyoto rats to run the CCK8 and ELISA assay, RC-PCR and Western blotting techniques to identify the effect of Urotensin II on the proliferation and secretion of VEGF in DPCs, data were analyzed by one-way ANOVA or t-test. Results. U II can increase the mRNA expression of proliferation markers Ki67 and PCNA. In addition, the Wnt/β-catenin pathway was activated by U II, but Wnt inhibitor DKK1 reversed the effect of U II. Conclusions. U II promoted the proliferation and secretion of VEGF in rat DPCs through activation of the Wnt-β-catenin signaling pathway

Research on quantitative inversion of ion adsorption type rare earth ore based on convolutional neural network

Rare earth resource is a national strategic resource, which plays an essential role in the field of high technology research and development. In this paper, we aim to use remote sensing quantitative inversion prospecting technology, use surface-to-surface mode, and model inversion and evaluation through convolutional neural network model to achieve a new research method for large-scale, low-cost, rapid and efficient exploration of ion-adsorbed rare earth ore. The results show that the RE2O3 content of samples has significant negative correlation with the second, third and fourth band of GF-2 image, but has no significant correlation with the first band of GF-2 image; the convolution neural network model can be used to reconstruct the RE2O3 content. The content distribution map of RE2O3 obtained by inversion is similar to that of geochemical map, which indicates that the convolution neural network model can be used to invert the RE2O3 content in the sampling area. The quantitative inversion results show that the content distribution characteristics of ion adsorption rare earth ore in the study area are basically consistent with the actual situation; there are two main high anomaly areas in the study area. The high anomaly area I is a known mining area, and the high anomaly area II can be a prospective area of ion adsorption type rare earth deposit. It shows that the remote sensing quantitative inversion prospecting method of ion adsorption type rare earth deposit based on Convolutional Neural Networks (CNN) model is feasible

Observed variability of intertropical convergence zone over 1998-2018

The intertropical convergence zone (ITCZ) accounts for more than 30% of the global precipitation and its variability has a great effect on the people living in the tropical area. It is the manifestation of the Hadley circulation, tropical dynamic and thermodynamic coupling and the air-sea interaction. Therefore, it is essential to understand the changes and variability of the ITCZ, including its position and intensity. Using observed precipitation from GPCP and TRMM 3B43, as well as the ERA5 reanalysis data, we examine the ITCZ variations over the global and seven regions from 1998-2018. These data sets show consistent ITCZ climatology and inter-annual variability. Except over Atlantic and eastern Pacific where ITCZ stays in the northern hemisphere, the ITCZ crosses the equator after equinoxes over other sections. There is no overall significant shift of annual mean ITCZ position over the globe and seven regions, except over the America section where the GPCP data show a significant increase trend of 0.8°decade-1 and over the western Pacific section where ERA5 data show a significant decrease trend of -1.2°decade-1. The ITCZ positions over the globe and Africa are related to both ENSO and NAO, while ITCZ position over eastern Pacific is significantly affected by ENSO and the Atlantic ITCZ is mainly related to NAO. Except for the western Pacific, all other sections are significantly related to local meridional surface temperature gradient, particularly over America, Atlantic and eastern Pacific. The meridional gradient variation of the vertically integrated moist static energy has generally good agreement with the shift of the intertropical convergence zone, particularly for the seasonal climatology over the Africa region. The relationship between ITCZ position and intensity shows complicated patterns, with positive correlation over the globe, but different correlations over different sections. The two observed data sets are more or less consistent, but ERA5 shows discrepancies over some sections. It is also found that the local meridional temperature gradient has more influences on the ITCZ positions than the global on

GCTOF-MS Combined LC-QTRAP-MS/MS Reveals Metabolic Difference Between Osteoarthritis and Osteoporotic Osteoarthritis and the Intervention Effect of Erxian Decoction

PurposeOP and OA are chronic bone diseases with high incidence in the middle-aged and elderly populations. The latest research shows that the pathological environment of OP may be involved in the aggravation of the pathological process of OA, and the pathological state of OP plays an important role in the aggravation of OA pathology. EXD is a traditional Chinese medicine decoction that has been used to treat osteoporosis. Therefore, we further study whether OA will be aggravated in the OP environment and whether EXD can alleviate OA by intervening in the OP environment. The purpose of this study was to analyze the effect of OP on OA metabolites by using metabolomic methods and to explore the intervention mechanism of EXD on osteoporotic OA.MethodThirty-two SD rats were randomly divided into normal group, OA group, OP-OA group, and EXD group. EXD was administered by gavage. Histopathological evaluation of cartilage tissue was performed using Saffron fast green and HE staining. Western blot and qRT-PCR were used to detect the expression levels of chondrogenesis genes SOX9, COL2A1, and COMP in cartilage tissue. GC-TOFMS and LC-QTRAP-MS/MS metabolomics methods were used to analyze the changes of metabolites in serum samples of rats in each group.ResultThe slice results showed that the cartilage damage in the OP-OA group was more serious than that in the OA group, which was significantly relieved after EXD intervention, indicating that the cartilage damage in the OP-OA group was more severe than that in the OA group and further reduced the protein and gene expressions of cartilage markers SOX9, COL2A1, and COMP. Thirty-seven substances were identified, and gentiopicroside, emodin, quercetin, and diosmetin were analyzed as possible active components of EXD. EXD treatment significantly reduced cartilage damage and reversed the expression of these markers. Metabolomics showed that EXD attenuated cartilage destruction by modulating the expression of cystine, chenodeoxycholate, and D-Turanose, involving glycolysis/gluconeogenesis, pantothenate, and CoA biosynthesis metabolic pathways.ConclusionThe OP environment may promote the progression of OA through metabolic factors. The benign intervention of EXD in osteoporotic OA involves cystine, chenodeoxycholate, and D-Turanose, and their associated glycolysis/gluconeogenesis, pantothenate, and CoA biosynthesis metabolic pathways. Therefore, we have a deep understanding of the metabolic-related intervention of EXD in osteoporotic OA and are eager to better understand the mechanism of multi-targeted intervention of EXD in bone metabolic lesions

The calcimimetic R-568 induces apoptotic cell death in prostate cancer cells

<p>Abstract</p> <p>Background</p> <p>Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in parathyroid cells. In this study, we investigated the effect of R-568 on cellular survival of prostate cancer cells.</p> <p>Methods</p> <p>Prostate cancer cell lines LNCaP and PC-3 were used in this study. Cellular survival was determined with MTT, trypan blue exclusion and fluorescent Live/Death assays. Western blot assay was utilized to assess apoptotic events induced by R-568 treatment. JC-1 staining was used to evaluate mitochondrial membrane potential.</p> <p>Results</p> <p>In cultured prostate cancer LNCaP and PC-3 cells, R-568 treatment significantly reduced cellular survival in a dose- and time-dependent manner. R-568-induced cell death was an apoptotic event, as evidenced by caspase-3 processing and PARP cleavage, as well as JC-1 color change in mitochondria. Knocking down calcium sensing receptor (CaSR) significantly reduced R-568-induced cytotoxicity. Enforced expression of Bcl-xL gene abolished R-568-induced cell death, while loss of Bcl-xL expression led to increased cell death in R-568-treated LNCaP cells,.</p> <p>Conclusion</p> <p>Taken together, our data demonstrated that calcimimetic R-568 triggers an intrinsic mitochondria-related apoptotic pathway, which is dependent on the CaSR and is modulated by Bcl-xL anti-apoptotic pathway.</p