4,191 research outputs found

    A Compact Third-order Gas-kinetic Scheme for Compressible Euler and Navier-Stokes Equations

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    In this paper, a compact third-order gas-kinetic scheme is proposed for the compressible Euler and Navier-Stokes equations. The main reason for the feasibility to develop such a high-order scheme with compact stencil, which involves only neighboring cells, is due to the use of a high-order gas evolution model. Besides the evaluation of the time-dependent flux function across a cell interface, the high-order gas evolution model also provides an accurate time-dependent solution of the flow variables at a cell interface. Therefore, the current scheme not only updates the cell averaged conservative flow variables inside each control volume, but also tracks the flow variables at the cell interface at the next time level. As a result, with both cell averaged and cell interface values the high-order reconstruction in the current scheme can be done compactly. Different from using a weak formulation for high-order accuracy in the Discontinuous Galerkin (DG) method, the current scheme is based on the strong solution, where the flow evolution starting from a piecewise discontinuous high-order initial data is precisely followed. The cell interface time-dependent flow variables can be used for the initial data reconstruction at the beginning of next time step. Even with compact stencil, the current scheme has third-order accuracy in the smooth flow regions, and has favorable shock capturing property in the discontinuous regions. Many test cases are used to validate the current scheme. In comparison with many other high-order schemes, the current method avoids the use of Gaussian points for the flux evaluation along the cell interface and the multi-stage Runge-Kutta time stepping technique.Comment: 27 pages, 38 figure

    Hidden Markov models for simultaneous testing of multiple gene sets and adaptive and dynamic adaptive procedures for false discovery rate control and estimation

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    This dissertation explored important issues of adaptive multiple testing problems. In Chapter 2, we showed that a class of dynamic adaptive procedures provides conservative point estimations for the proportion of true null hypotheses and FDR. These procedures are truly adaptive procedures because of their ability to adapt to the data when estimating null proportion. Thus, the dynamic adaptive procedures offer a solution to the problem of choosing the tuning parameters for adaptive procedures. In Chapter 3, we discussed important issues of gene set testing, which are commonly used in biological research, and the related multiple testing problems. We developed new methodology based on a hidden Markov model to test multiple gene sets of the Gene Ontology. Our method not only honors the logical relationships among the null hypotheses but also uses them to achieve more powerful results than other existing methods. In a sense, our method is able to adapt to dependences among null hypotheses to make better inference. In Chapter 4, we developed a more computationally efficient method to implement our hidden Markov methodology
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