Anti-resonance, inhibited coupling and mode transition in depressed core fibers

The depressed core fiber (DCF), consisting of a low-index solid core, a high-index cladding and air surrounding, is in effect a bridge between the conventional step-index fiber and the tube-type hollow-core fiber from the point of view of the index profile. In this paper the dispersion diagram of a DCF is obtained by solving the full-vector eigenvalue equations and analyzed using the theory of anti-resonant and the inhibited coupling mechanisms. While light propagation in tube-type hollow-core fibers is commonly described by the symmetric planar waveguide model, here we propose an asymmetric planar waveguide for the DCFs in an anti-resonant reflecting optical waveguide (ARROW) model. It is found that the anti-resonant core modes in the DCFs have real effective indices, compared to the anti-resonant core modes with complex effective indices in the tube-type hollow-core fibers. The anti-resonant core modes in the DCFs exhibit similar qualitative and quantitative behavior as the core modes in the conventional step-index fibers. The full-vector analytical results for the simple-structure DCFs can contribute to a better understanding of the anti-resonant and inhibited coupling guidance mechanisms in other complex inversed index fibers

Spectral dependence of transmission losses in high-index polymer coated no-core fibers

A high-index polymer coated no-core fiber (PC-NCF) is effectively a depressed core fiber, where the light is guided by the anti-resonant, inhibited coupling and total internal reflection effects and the dispersion diagram shows periodic resonant and anti-resonant bands. In this paper, the transmission spectra of the straight and bent PC-NCFs (length > 5 cm) are measured and analyzed from a modal dispersion perspective. For the purpose of the study, the PC-NCFs are contained within a fiber hetero-structure using two single-mode fiber (SMF) pigtails forming a SMF-PC-NCF-SMF structure. The anti-resonance spectral characteristics are suppressed by the multimode interference in the PC-NCF with a short fiber length. The increase of the length or fiber bending (bend radius > 28 cm) can make the anti-resonance dominate and result in the periodic transmission loss dips and variations in the depth of these loss dips, due to the different modal intensity distributions in different bands and the material absorption of the polymer. The PC-NCFs are expected to be used in many devices including curvature sensors and tunable loss filters, as the experiments show that the change of loss dip around 1550 nm is over 31 dB and the average sensitivity is up to 14.77 dB/m-1 in the bend radius range from to 47.48 cm. Our study details the general principles of the effect of high-index layers in the formation of the transmission loss dips in fiber optics

SNS OPTICAL FIBER STRUCTURE SENSOR FOR DIRECT DETECTION OF THE PHASE TRANSITION IN C18H38 N-ALKANE MATERIAL

A singlemode-no-core-singlemode (SNS) fiber structure optical sensor for detecting the solid-liquid phase change in a phase change material: C18H38 n-alkane material (n-octadecane) is proposed and demonstrated. The transmission-type sensor probe consists of a short section of no-core fiber sandwiched between two sections of a singlemode fiber. Phase changes in n-octadecane are accompanied by large step-like variations of its refractive index (RI). Such a large discontinuous change of the n-octadecane’s RI during its phase transition, leads to the corresponding step-like change in the transmitted optical power that can reliably indicate the phase change of the sample in the vicinity of the sensor. In addition, the proposed sensor can detect whether the sample is in solid or liquid phase based on a single power measurement, can detect supercooling, and is resistant to bending and strain disturbances during the measurements. The results of this work also illustrate that the proposed sensor can be applied to detect liquid-solid phase changes in other materials with thermo-optic properties similar to n-octadecane

SNS optical fiber sensor for direct detection of phase transitions in C18H38 n-alkane material

A single-mode-no-core-single-mode (SNS) fiber optical sensor for the detection of solid-liquid and liquid-solid phase changes in C18H38 n-alkane (n-octadecane) is proposed and demonstrated. The transmission-type sensor probe consists of a short section of no-core fiber sandwiched between two sections of a single-mode fiber. Phase changes in n-octadecane are accompanied by large step-like variations of its refractive index (RI). Such a large discontinuous change of the n-octadecane’s RI during its phase transition leads to the corresponding step-like change in the transmitted optical power that can reliably indicate the phase change of the sample in the vicinity of the sensor. The proposed sensor probe is simple, accurate and is capable of detecting the material’s phase based on a single measurement. The results of this work suggest that the proposed sensor is potentially capable of detecting liquid-solid phase changes in other materials whose thermo-optic properties are similar to those of n-octadecane

An inventory of invasive alien species in China

Invasive alien species (IAS) are a major global challenge requiring urgent action, and the Strategic Plan for Biodiversity (2011–2020) of the Convention on Biological Diversity (CBD) includes a target on the issue. Meeting the target requires an understanding of invasion patterns. However, national or regional analyses of invasions are limited to developed countries. We identified 488 IAS in China’s terrestrial habitats, inland waters and marine ecosystems based on available literature and field work, including 171 animals, 265 plants, 26 fungi, 3 protists, 11 procaryots, and 12 viruses. Terrestrial plants account for 51.6% of the total number of IAS, and terrestrial invertebrates (104 species) for 21.3%. Of the total numbers, 67.9% of plant IAS and 34.8% of animal IAS were introduced intentionally. All other taxa were introduced unintentionally despite very few animal and plant species that invaded naturally. In terms of habitats, 64.3% of IAS occur on farmlands, 13.9% in forests, 8.4% in marine ecosystems, 7.3% in inland waters, and 6.1% in residential areas. Half of all IAS (51.1%) originate from North and South America, 18.3% from Europe, 17.3% from Asia not including China, 7.2% from Africa, 1.8% from Oceania, and the origin of the remaining 4.3% IAS is unknown. The distribution of IAS can be divided into three zones. Most IAS are distributed in coastal provinces and the Yunnan province; provinces in Middle China have fewer IAS, and most provinces in West China have the least number of IAS. Sites where IAS were first detected are mainly distributed in the coastal region, the Yunnan Province and the Xinjiang Uyghur Autonomous Region. The number of newly emerged IAS has been increasing since 1850. The cumulative number of firstly detected IAS grew exponentially

Promoting Cardiac Repair through Simple Engineering of Nanoparticles with Exclusive Targeting Capability toward Myocardial Reperfusion Injury by Thermal Resistant Microfluidic Platform

Nanoparticle (NP)-based intravenous administration represents the most convenient cardiac targeting delivery routine, yet, there are still therapeutic issues due to the lack of targeting efficiency and specificity. Active targeting methods using functionalization of ligands onto the NPs' surface may be limited by trivial modification procedures and reduced targeting yield in vivo. Here, a microfluidics assisted single step, green synthesis method is introduced for producing targeting ligands free heart homing NPs in a tailored manner. The generated beta-glucan-based NPs exhibit precise and efficient targeting capability toward Dectin-1(+) monocytes/macrophages, which are confirmed as main pathogenesis mediators for cardiac ischemic/reperfusion (I/R) injury, with a sequentially enhanced cardiac NP accumulation, and this targeting strategy is exclusively suitable for cardiac I/R but not for other cardiovascular diseases, as confirmed both in murine and human model. Comparing to FDA-approved nano-micelles formulation, beta-glucan NPs loaded with NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome inhibitor (CY-09) exhibit better efficiency in ameliorating myocardial injury and heart failure induced by surgically induced I/R. These findings indicate a simple production of targeting-ligand free NPs, and demonstrate their potential therapeutic applications for preclinical I/R-induced cardiac injury amelioration.Peer reviewe

Promoting Cardiac Repair through Simple Engineering of Nanoparticles with Exclusive Targeting Capability toward Myocardial Reperfusion Injury by Thermal Resistant Microfluidic Platform

Nanoparticle (NP)-based intravenous administration represents the most convenient cardiac targeting delivery routine, yet, there are still therapeutic issues due to the lack of targeting efficiency and specificity. Active targeting methods using functionalization of ligands onto the NPs' surface may be limited by trivial modification procedures and reduced targeting yield in vivo. Here, a microfluidics assisted single step, green synthesis method is introduced for producing targeting ligands free heart homing NPs in a tailored manner. The generated beta-glucan-based NPs exhibit precise and efficient targeting capability toward Dectin-1(+) monocytes/macrophages, which are confirmed as main pathogenesis mediators for cardiac ischemic/reperfusion (I/R) injury, with a sequentially enhanced cardiac NP accumulation, and this targeting strategy is exclusively suitable for cardiac I/R but not for other cardiovascular diseases, as confirmed both in murine and human model. Comparing to FDA-approved nano-micelles formulation, beta-glucan NPs loaded with NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome inhibitor (CY-09) exhibit better efficiency in ameliorating myocardial injury and heart failure induced by surgically induced I/R. These findings indicate a simple production of targeting-ligand free NPs, and demonstrate their potential therapeutic applications for preclinical I/R-induced cardiac injury amelioration.Peer reviewe

Research progress of soy peptide，wheat peptide and collagen peptide in sports nutrition

This paper reviews the development trend and prospect of sports nutrition market，as well as the research advance and functions of soy peptide，wheat peptide and collagen peptide in sports nutrition.The functions mainly include offering the required protein and essential amino-acid (EAA)，relieving fatigue，repairing of exercise-induced muscle damage，promoting fat metabolism，elevating athletic ability and so on.The paper mainly describes the molecular weight distribution，essential amino acid composition and function of different peptides in sports performance which will provide some references and theoretical support for the application and development of sports nutrition products

Axin downregulates TCF-4 transcription via β-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells

<p>Abstract</p> <p>Background</p> <p>We previously reported that overexpression of Axin downregulates T cell factor-4 (TCF-4) transcription. However, the mechanism(s) by which Axin downregulates the transcription and expression of TCF-4 is not clear. It has been reported that β-catenin promotes and p53 inhibits TCF-4 transcription, respectively. The aim of this study was to investigate whether β-catenin and/or p53 is required for Axin-mediated downregulation of TCF-4.</p> <p>Results</p> <p>Axin mutants that lack p53/HIPK2 and/or β-catenin binding domains were expressed in lung cancer cells, BE1 (mutant p53) and A549 (wild type p53). Expression of Axin or AxinΔp53 downregulates β-catenin and TCF-4, and knock-down of β-catenin upregulates TCF-4 in BE1 cells. However, expression of AxinΔβ-ca into BE1 cells did not downregulate TCF-4 expression. These results indicate that Axin downregulates TCF-4 transcription via β-catenin. Although overexpression of wild-type p53 also downregulates TCF-4 in BE1 cells, cotransfection of p53 and AxinΔβ-ca did not downregulate TCF-4 further. These results suggest that Axin does not promote p53-mediated downregulation of TCF-4. Axin, AxinΔp53, and AxinΔβ-ca all downregulated β-catenin and TCF-4 in A549 cells. Knock-down of p53 upregulated β-catenin and TCF-4, but cotransfection of AxinΔβ-ca and p53 siRNA resulted in downregulation of β-catenin and TCF-4. These results indicate that p53 is not required for Axin-mediated downregulation of TCF-4. Knock-down or inhibition of GSK-3β prevented Axin-mediated downregulation of TCF-4. Furthermore, expression of Axin and AxinΔp53, prevented the proliferative and invasive ability of BE1 and A549, expression of AxinΔβ-ca could only prevented the proliferative and invasive ability effectively.</p> <p>Conclusions</p> <p>Axin downregulates TCF-4 transcription via β-catenin and independently of p53. Axin may also inhibits the proliferation and invasion of lung cancer cells via β-catenin and p53.</p