8,202 research outputs found
Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for the treatment of multiple autoimmune diseases (1). In this study, we investigated the therapeutic effects and molecule mechanism of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment significantly alleviated clinical development in the myelin oligodendrocyte glycoprotein (MOG35–55) peptide-induced EAE model, markedly decreased inflammatory cell infiltration into the central nervous system and reduced demyelination. Further, carnosol inhibited Th17 cell differentiation and signal transducer and activator of transcription 3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia. Taken together, our results show that carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as MS
A SiO J = 5 - 4 Survey Toward Massive Star Formation Regions
We performed a survey in the SiO line toward a sample of
199 Galactic massive star-forming regions at different evolutionary stages with
the SMT 10 m and CSO 10.4 m telescopes. The sample consists of 44 infrared dark
clouds (IRDCs), 86 protostellar candidates, and 69 young \HII\ regions. We
detected SiO line emission in 102 sources, with a detection
rate of 57\%, 37\%, and 65\% for IRDCs, protostellar candidates, and young
\HII\ regions, respectively. We find both broad line with Full Widths at Zero
Power (FWZP) 20 \kms and narrow line emissons of SiO in objects at various
evolutionary stages, likely associated with high-velocity shocks and
low-velocity shocks, respectively. The SiO luminosities do not show apparent
differences among various evolutionary stages in our sample. We find no
correlation between the SiO abundance and the luminosity-to-mass ratio,
indicating that the SiO abundance does not vary significantly in regions at
different evolutionary stages of star formation.Comment: 25 pages, 9 figures, 5 tables, accepted for publication in Ap
Interacting heavy fermions in a disordered optical lattice
We have theoretically studied the effect of disorder on ultracold
alkaline-earth atoms governed by the Kondo lattice model in an optical lattice
via simplified double-well model and hybridization mean-field theory.
Disorder-induced narrowing and even complete closure of hybridization gap have
been predicted and the compressibility of the system has also been investigated
for metallic and Kondo insulator phases in the presence of the disordered
potential. To make connection to the experimental situation, we have
numerically solved the disordered Kondo lattice model with an external harmonic
trap and shown both the melting of Kondo insulator plateau and an
compressibility anomaly at low-density
Mining Parallel Text from the Web based on Sentence Alignment
PACLIC 21 / Seoul National University, Seoul, Korea / November 1-3, 200
Millimeter Spectral Line Mapping Observations Toward Four Massive Star Forming HII Regions
We present spectral line mapping observations toward four massive
star-forming regions (Cepheus A, DR21S, S76E and G34.26+0.15), with the IRAM 30
meter telescope at 2 mm and 3 mm bands. Totally 396 spectral lines from 51
molecules, one helium recombination line, ten hydrogen recombination lines, and
16 unidentified lines were detected in these four sources. An emission line of
nitrosyl cyanide (ONCN, 14-13) was detected in G34.26+0.15,
as first detection in massive star-forming regions. We found that the
-CH and NHD show enhancement in shocked regions as
suggested by evidences of SiO and/or SO emission. Column density and rotational
temperature of CHCN were estimated with the rotational diagram method for
all four sources. Isotope abundance ratios of C/C were derived
using HCN and its C isotopologue, which were around 40 in all four
massive star-forming regions and slightly lower than the local interstellar
value (65). N/N and O/O abundance ratios in
these sources were also derived using double isotopic method, which were
slightly lower than that in local interstellar medium. Except for Cep A,
S/S ratio in the other three targets were derived, which were
similar to that in the local interstellar medium. The column density ratios of
N(DCN)/N(HCN) and N(DCO)/N(HCO) in these sources were more than two
orders of magnitude higher than the elemental [D]/[H] ratio, which is
1.510. Our results show the later stage sources, G34.26+0.15 in
particular, present more molecular species than earlier stage ones. Evidence of
shock activity is seen in all stages studied.Comment: 32 pages, 11 figures, 8 tables, accepted for publication in MNRA
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