Modeling and Simulation Study of Designer’s Bidirectional Behavior of Task Selection in Open Source Design Process

Open source design (OSD) is an emerging mode of product design. In OSD process, how to select right tasks directly influences the efficiency and quality of task completion, hence impacting the whole evolution process of OSD. In this paper, designer’s bidirectional behavior of task selection integrating passive selection based on website recommendation and autonomous selection is modeled. First, the model of passive selection behavior by website recommendation is proposed with application of collaborative filtering algorithm, based on a three-dimensional matrix including information of design agents, tasks, and skills; second, the model of autonomous selection behavior is described in consideration of factors such as skill and incentive; third, the model of bidirectional selection behavior is described integrating the aforementioned two selection algorithms. At last, contrast simulation analysis of bidirectional selection, passive selection based on website recommendation, and autonomous selection is proposed with ANOVA, and results show that task selection behavior has significant effect on OSD evolution process and that bidirectional selection behavior is more effective to shorten evolution cycle according to the experiment settings. In addition, the simulation study testifies the model of bidirectional selection by describing the task selection process of OSD in microperspective

Adherence to an antioxidant diet and lifestyle is associated with reduced risk of cardiovascular disease and mortality among adults with nonalcoholic fatty liver disease: evidence from NHANES 1999–2018

BackgroundNonalcoholic fatty liver disease (NAFLD) stands a prevalent chronic liver condition significantly influenced by oxidative stress. We investigated the unclear relationship between antioxidant-rich diet and lifestyle and cardiovascular disease (CVD) prevalence rate and mortality in adult patients with NAFLD.MethodsThis study utilized data from the National Health and Nutrition Examination Survey (NHAENS) spanning from 1999 to 2018 to investigate the association between adherence to an antioxidant-rich diet and lifestyle and the cardiovascular disease (CVD) prevalence rate and mortality in adult patients with NAFLD. The study employed the Oxidative Balance Score (OBS) to define antioxidant diet and lifestyle.ResultsIncluding 8,670 adult patients with NAFLD, the study revealed an inverse association between OBS and the prevalence of most CVD conditions. Fully adjusted models demonstrated that each unit increase in diet OBS, lifestyle OBS, and overall OBS corresponded to a 2, 7, and 2% reduction in all-cause mortality, respectively. In models 2, findings revealed that lifestyle Q2 and Q3 were linked to reduced cancer mortality, whereas diet and overall OBS did not exhibit an association. Additionally, Stratified analysis revealed that age (<45 years) and education level (> high school) significantly influenced the association between the OBS and the prevalence of CVD.ConclusionThese results underscore the protective link between adherence to an antioxidant diet and lifestyle and a diminished prevalence of CVD and mortality in adults with NAFLD, particularly among younger and higher-educated populations

The non-occurrence of events

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Study on the influence diffusion of SMEs in open-source communities from the perspective of complex networks

In the era of digital economy, enterprise research and development (R&D) tends to be open-source. Due to their limited resources, small and medium-sized enterprises (SMEs) can join open-source platforms to get additional creative resources and technical support. In this context, from the perspective of complex networks, the influence diffusion of SMEs after embedding open-source innovation networks is studied in this paper. First, an integrated simulation model including a network model, agent model and innovative diffusion model is constructed. Second, the influence diffusion strategy is proposed considering initial impact, embedding timing and connection mode (same-match and heterogeneous) of the enterprise. Third, the dynamic simulation of the influence diffusion process of SMEs demonstrates that embedding timing has a significant impact. There is no significant difference in the influence diffusion at the early and mature stages in the evolution process of open-source innovation networks. The initial impact of enterprises has a significant influence on the diffusion during the developing period, but the effect on its influence diffusion at the initial and mature stages is not obvious. Finally, in light of experiment results, it is clear that the open-source platform plays an important role on the growth of SMEs as evidenced by the close correlation between the spread of SMEs' influence within the open-source innovation network and the community's stage of development

Role of GM-CSF in lung balance and disease

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor originally identified as a stimulus that induces the differentiation of bone marrow progenitor cells into granulocytes and macrophages. GM-CSF is now considered to be a multi-origin and pleiotropic cytokine. GM-CSF receptor signals activate JAK2 and induce nuclear signals through the JAK-STAT, MAPK, PI3K, and other pathways. In addition to promoting the metabolism of pulmonary surfactant and the maturation and differentiation of alveolar macrophages, GM-CSF plays a key role in interstitial lung disease, allergic lung disease, alcoholic lung disease, and pulmonary bacterial, fungal, and viral infections. This article reviews the latest knowledge on the relationship between GM-CSF and lung balance and lung disease, and indicates that there is much more to GM-CSF than its name suggests