1,120 research outputs found
Comparison of serum apolipoprotein A-I between Chinese multiple sclerosis and other related autoimmune disease
<p>Abstract</p> <p>Background</p> <p>Serum apolipoprotein (apo) A-I was considered to be an immune regulator and could suppress pro-inflammatory cytokines generated by activated T cell in some autoimmune diseases. However, the change of serum apoA-I levels in multiple sclerosis (MS) patients is unknown.</p> <p>Methods</p> <p>In the presentation we performed a study on serum apoA-I levels in the patients with MS. We enrolled some age and gender matched patients with MS, autoimmune demyelinating diseases (Guillain-Barre Syndrome and Clinically Isolated Syndrome), neuroinflammatory diseases (viral encephalitis), autoimmune connective diseases (rheumatoid arthritis and systemic lupus erythematosus) and healthy control groups, and tested their serum lipids levels: total cholesterol (TC), triglyceride (TG), high-density lipoproteins (HDL), apolipoproteinB100 (apoB100), apolipoproteinA-I (apoA-I).</p> <p>Results</p> <p>For all patients, age had no effect on serum apoA-I levels (<it>P </it>> 0.05). Meanwhile, we proved the highest serum apoA-I levels in MS patients and the lowest serum apoA-I levels in SLE patients. Serum apoA-I levels was significantly elevated in female MS patients (P = 0.033; P < 0.05).</p> <p>Conclusion</p> <p>In short we believed that patients with MS and other autoimmune demyelination had significantly decreased serum levels of apo A-I.</p
Supermassive Black Holes with High Accretion Rates in Active Galactic Nuclei. III. Detection of Fe II Reverberation in Nine Narrow-Line Seyfert 1 Galaxies
This is the third in a series of papers reporting on a large
reverberation-mapping campaign aimed to study the properties of active galactic
nuclei (AGNs) with high accretion rates. We present new results on the
variability of the optical Fe II emission lines in 10 AGNs observed by the
Yunnan Observatory 2.4m telescope during 2012--2013. We detect statistically
significant time lags, relative to the AGN continuum, in nine of the sources.
This accurate measurement is achieved by using a sophisticated spectral fitting
scheme that allows for apparent flux variations of the host galaxy, and several
narrow lines, due to the changing observing conditions. Six of the newly
detected lags are indistinguishable from the Hbeta lags measured in the same
sources. Two are significantly longer and one is slightly shorter. Combining
with Fe II lags reported in previous studies, we find a Fe II
radius--luminosity relationship similar to the one for Hbeta, although our
sample by itself shows no clear correlation. The results support the idea that
Fe II emission lines originate in photoionized gas which, for the majority of
the newly reported objects, is indistinguishable from the Hbeta-emitting gas.
We also present a tentative correlation between the lag and intensity of Fe II
and Hbeta and comment on its possible origin.Comment: 14 pages, 10 figures, accepted for publication in The Astrophysical
Journa
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