6,054 research outputs found
Magnetic Moments of Pentaquarks
If the of and pentaquarks is really found to
be by future experiments, they will be accompanied by
partners in some models. It is reasonable to expect that
these states will also be discovered in the near future with
the current intensive experimental and theoretical efforts. We estimate
pentaquark magnetic moments using different models.Comment: 13 page
High performance perovskite solar cells using Cu9S5 supraparticles incorporated hole transport layers
Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric cancer patients
Zipper-interacting Protein Kinase (ZIPK) belongs to the death-associated protein kinase family. ZIPK has been characterized as a tumor suppressor in various tumors, including gastric cancer. On the other hand, ZIPK also promotes cell survival. In this study, both in vitro and in vivo assays indicated that ZIPK promoted cell growth, proliferation, migration, invasion, tumor formation and metastasis in nude mice. ZIPK induced epithelial-mesenchymal transition (EMT) with increasing expression of ÎČ-catenin, mesenchymal markers, Snail and Slug, and with decreasing expression of E-cadherin. Furthermore, ZIPK activated the AKT/IÎșB/NF-ÎșB pathway, which can promote EMT and metastasis. Additionally, ZIPK expression was detected in human primary gastric cancer and their matched metastatic lymph node samples by immunohistochemistry. Increased expression of ZIPK in lymph node metastases was significantly associated with stage VI and abdominal organ invasion. Survival analysis revealed that patients with increased ZIPK expression in metastatic lymph nodes had poor disease-specific survival. Taken together, our study reveals that ZIPK is a pro-oncogenic factor, which promotes cancer metastasis.published_or_final_versio
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Influence of cooling speed on the physical and mechanical properties of granite in geothermal-related engineering
In deep-earth engineering, the high earth temperature can significantly affect the rock's mechanical properties, especially when the rock is cooled during the construction process. Accordingly, whether the cooling speed affects the mechanical and physical properties of rocks is worth to be investigated. The present study explored the influence of the cooling rate on the physical and chemical properties of granite heated at 25â800â°C. The mechanical and physical properties involved in this study included uniaxial compression strength, peak strain, modulus, P-wave velocity, mass and volume, the change of which could reflect the sensitivity of granite to the cooling rate. Acoustic emission (AE) monitoring, microscopic observation, and X-ray diffraction (XRD) are used to analyze the underlying damage mechanism. It is found that more AE signals and large-scale cracks are accounted for based on the b-value method when the specimens are cooled by water. Furthermore, the microscopic observation by polarized light microscopy indicates that the density, opening degree, and connectivity of the cracks under water cooling mode are higher than that under natural cooling mode. In addition, the XRD illustrates that there is no obvious change in mineral content and diffraction angle at different temperatures, which confirms that the change of mechanical properties is not related to the chemical properties. The present conclusion can provide a perspective to assess the damage caused by different cooling methods to hot rocks.The National Natural Science Foundation of China, Grant/Award Number: 41702326;the Innovative Experts, Longâterm Program of Jiangxi Province, Grant/Award Number:jxsq2018106049; the Natural Science Foundation of Jiangxi Province,Grant/Award Number: 20202ACB214006;the Supported by Program of Qing jiang Excellent Young Talents, Jiangxi University of Science and Technolog
Search for D to phi l nu and measurement of the branching fraction for D to phi pi
Using a data sample of integrated luminosity of about 33 pb collected
around 3.773 GeV with the BESII detector at the BEPC collider, the semileptonic
decays , and the hadronic
decay are studied. The upper limits of the branching
fractions are set to be 2.01% and 2.04% at the 90% confidence level. The ratio of the
branching fractions for relative to is measured to be . In addition, the
branching fraction for is obtained to be .Comment: 6 pages, 5 figures, to be published in Eur.Phys.J.
Heavy and Light Pentaquark Chiral Lagrangian
Using the SU(3) flavor symmetry, we construct the chiral Lagrangians for the
light and heavy pentaquarks. The correction from the nonzero quark is taken
into account perturbatively. We derive the Gell-MannOkubo type relations for
various pentaquark multiplet masses and Coleman-Glashow relations for
anti-sextet heavy pentaquark magnetic moments. We study possible decays of
pentaquarks into conventional hadrons. We also study the interactions between
and within various pentaquark multiplets and derive their coupling constants in
the symmetry limit. Possible kinematically allowed pionic decay modes are
pointed out
Prevalence of phase variable epigenetic invertons among host-associated bacteria.
Type I restriction-modification (R-M) systems consist of a DNA endonuclease (HsdR, HsdM and HsdS subunits) and methyltransferase (HsdM and HsdS subunits). The hsdS sequences flanked by inverted repeats (referred to as epigenetic invertons) in certain Type I R-M systems undergo invertase-catalyzed inversions. Previous studies in Streptococcus pneumoniae have shown that hsdS inversions within clonal populations produce subpopulations with profound differences in the methylome, cellular physiology and virulence. In this study, we bioinformatically identified six major clades of the tyrosine and serine family invertases homologs from 16 bacterial phyla, which potentially catalyze hsdS inversions in the epigenetic invertons. In particular, the epigenetic invertons are highly enriched in host-associated bacteria. We further verified hsdS inversions in the Type I R-M systems of four representative host-associated bacteria and found that each of the resultant hsdS allelic variants specifies methylation of a unique DNA sequence. In addition, transcriptome analysis revealed that hsdS allelic variations in Enterococcus faecalis exert significant impact on gene expression. These findings indicate that epigenetic switches driven by invertases in the epigenetic invertons broadly operate in the host-associated bacteria, which may broadly contribute to bacterial host adaptation and virulence beyond the role of the Type I R-M systems against phage infection
Direct Measurements of the Branching Fractions for Inclusive and Inclusive Semileptonic Decays of and Mesons
With singly-tagged samples selected from the data collected at and
around 3.773 GeV with the BESII detector at the BEPC collider, we have measured
the branching fractions for the inclusive decays of and
mesons, which are , , and
, respectively. We have also
measured the branching fractions for the inclusive semileptonic decays of
and mesons to be and . These yield the ratio of their partial
widths to be .Comment: 6 pages, 5 figure
Accurate Diagnosis of Colorectal Cancer Based On Histopathology Images Using Artificial Intelligence
Background: Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming and knowledge-intensive, but is essential for CRC patientsâ treatment. The current heavy workload of pathologists in clinics/hospitals may easily lead to unconscious misdiagnosis of CRC based on daily image analyses.
Methods: Based on a state-of-the-art transfer-learned deep convolutional neural network in artificial intelligence (AI), we proposed a novel patch aggregation strategy for clinic CRC diagnosis using weakly labeled pathological whole-slide image (WSI) patches. This approach was trained and validated using an unprecedented and enormously large number of 170,099 patches, \u3eâ14,680 WSIs, from \u3eâ9631 subjects that covered diverse and representative clinical cases from multi-independent-sources across China, the USA, and Germany.
Results: Our innovative AI tool consistently and nearly perfectly agreed with (average Kappa statistic 0.896) and even often better than most of the experienced expert pathologists when tested in diagnosing CRC WSIs from multicenters. The average area under the receiver operating characteristics curve (AUC) of AI was greater than that of the pathologists (0.988 vs 0.970) and achieved the best performance among the application of other AI methods to CRC diagnosis. Our AI-generated heatmap highlights the image regions of cancer tissue/cells.
Conclusions: This first-ever generalizable AI system can handle large amounts of WSIs consistently and robustly without potential bias due to fatigue commonly experienced by clinical pathologists. It will drastically alleviate the heavy clinical burden of daily pathology diagnosis and improve the treatment for CRC patients. This tool is generalizable to other cancer diagnosis based on image recognition
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