Voltammetry at porous electrodes: A theoretical study

Theory is presented to simulate both chronoamperometry and cyclic voltammetry at porous electrodes fabricated by means of electro-deposition around spherical templates. A theoretical method to extract heterogeneous rate constants for quasireversible and irreversible systems is proposed by the approximation of decoupling of the diffusion within the porous electrode and of bulk diffusion to the electrode surface

An investigation into machine pattern recognition based on time-frequency image feature extraction using a support vector machine

In this article, a new method of pattern recognition for machine working conditions is presented that is based on time-frequency image (TFI) feature extraction and support vector machines (SVMs). In this study, the Hilbert time-frequency spectrum (HTFS) is used to construct TFIs because of its good performance in non-stationary and non-linear signal analysis. Cyclostationarity signal analysis is a pre-processing method for improving the performance of the HTFS in the construction of TFIs. Feature extraction for TFIs is investigated in detail to construct a feature vector for pattern recognition. Gravity centre and information entropy of TFIs are used to construct the feature vector for pattern recognition. SVMs are used for different working conditions classification by the constructed feature vector because of its powerful performance even for small samples. In the end, rolling bearing pattern recognition is used as an example to testify the effectiveness of this method. According to the result analysis, it can be concluded that this method will contribute to the development of preventative maintenance

Effect of hukou Accessibility on Migrants’ Long Term Settlement Intention in Destination

Migrants’ long-term settlement intention in urban areas has been emphasized by both policy makers and researchers in promoting urbanization and coordinating regional economic development. This study advances the body of knowledge by investigating the effect of what E.S. Lee has proposed as ‘intervening obstacles’ in the ‘push-and-pull’ theory—the difficulty in obtaining hukou in migration destination, on their long-term settlement intention in urban areas. Logistic regressions were applied to examine the effect of urban registered residence system (the hukou system) accessibility on migrants’ long-term settlement intention in urban areas, as well as the determinants of subjective evaluated difficulty in obtaining urban hukou, based on a nation-wide large-scale survey in 46 Chinese cities. Our results suggest that difficulty in obtaining urban hukou does play an important role in shaping country-wide population movement. However, the negative impact of hukou difficulty on migrant workers’ residence intention is not linear, and only when the threshold in obtaining hukou is too high and difficult to achieve will migrant workers choose to return to their hometown in the long term. Moreover, the subjective evaluation of difficulty is further influenced by personal capability and living conditions in cities. This study provides pragmatic implications for administrations from either push side or pull side to improve habitant-related development strategies

MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors

Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have synergistic roles in cellular systems and their disruption may cause diseases including cancer. FFLs may include two regulators such as transcription factors (TFs) and microRNAs (miRNAs). In this study, we extensively investigated TF and miRNA regulation pairs, their FFLs, and TF-miRNA mediated regulatory networks in two major types of testicular germ cell tumors (TGCT): seminoma (SE) and non-seminoma (NSE). Specifically, we identified differentially expressed mRNA genes and miRNAs in 103 tumors using the transcriptomic data from The Cancer Genome Atlas. Next, we determined significantly correlated TF-gene/miRNA and miRNA-gene/TF pairs with regulation direction. Subsequently, we determined 288 and 664 dysregulated TF-miRNA-gene FFLs in SE and NSE, respectively. By constructing dysregulated FFL networks, we found that many hub nodes (12 out of 30 for SE and 8 out of 32 for NSE) in the top ranked FFLs could predict subtype-classification (Random Forest classifier, average accuracy ≥90%). These hub molecules were validated by an independent dataset. Our network analysis pinpointed several SE-specific dysregulated miRNAs (miR-200c-3p, miR-25-3p, and miR-302a-3p) and genes (EPHA2, JUN, KLF4, PLXDC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR-367-3p, miR-519d-3p, and miR-96-5p) and genes (NR2F1 and NR2F2). This study is the first systematic investigation of TF and miRNA regulation and their co-regulation in two major TGCT subtypes

A New Method for Analyzing Integrated Stealth Ability of Penetration Aircraft

AbstractTaking into account the limitations of existing stealth performance analysis methods, a method termed as the integrated stealth performance analysis method is proposed for evaluating the stealth ability of the penetration aircraft. Based on various target radar cross section (RCS) scattering characters, this article integrates the relevant parameters needed for building up target circumferential RCS scattering model and proposes the RCS scattering controlling parameters to control the changing trends of the relevant model RCS scattering characters. According to the radar dynamic detecting characters during the whole penetration course, a dynamic stealth performance evaluating model is proposed accompanied by a series of stealth ability estimation rules. This new analysis method can enhance the integrality and dependability of the stealth analysis conclusions and summarize the relationship between the target RCS scattering characters and their effects on stealth performance. The rules indicated by this relationship can be used as the reference for designing new type of stealth aircraft and setting up specific penetration tactics

Demonstration of two novel methods for predicting functional siRNA efficiency

BACKGROUND: siRNAs are small RNAs that serve as sequence determinants during the gene silencing process called RNA interference (RNAi). It is well know that siRNA efficiency is crucial in the RNAi pathway, and the siRNA efficiency for targeting different sites of a specific gene varies greatly. Therefore, there is high demand for reliable siRNAs prediction tools and for the design methods able to pick up high silencing potential siRNAs. RESULTS: In this paper, two systems have been established for the prediction of functional siRNAs: (1) a statistical model based on sequence information and (2) a machine learning model based on three features of siRNA sequences, namely binary description, thermodynamic profile and nucleotide composition. Both of the two methods show high performance on the two datasets we have constructed for training the model. CONCLUSION: Both of the two methods studied in this paper emphasize the importance of sequence information for the prediction of functional siRNAs. The way of denoting a bio-sequence by binary system in mathematical language might be helpful in other analysis work associated with fixed-length bio-sequence

An investigation into frequency resolution estimation model for impact signal analysis by using Hilbert spectrum and condition classification for marine diesel engine

In this paper, frequency resolution determination method is investigated according to Hilbert spectrum performance for impact signal analysis. A new constructed performance estimation model for the best frequency resolution is put forward in this research for the impact signal pattern recognition. Different parameters in the time-frequency distribution by using Hilbert spectrum are considered in this estimation model for the best frequency resolution determination. To verify the effectiveness of this estimation model, numerical simulation is used for Hilbert spectrum construction analysis. At the same time, different marine diesel engine working condition signals analysis are also used to illustrate the methodology developed in this research and verify the effectiveness. It can be concluded that this method can contribute the development for impact signal analysis by using Hilbert spectrum