Lack of Hypothalamus Polysialylation Inducibility Correlates With Maladaptive Eating Behaviors and Predisposition to Obesity

High variability exists in individual susceptibility to develop overweight in an obesogenic environment and the biological underpinnings of this heterogeneity are poorly understood. In this brief report, we show in mice that the vulnerability to diet-induced obesity is associated with low level of polysialic acid-neural cell adhesion molecule (PSA-NCAM), a factor of neural plasticity, in the hypothalamus. As we previously shown that reduction of hypothalamic PSA-NCAM is sufficient to alter energy homeostasis and promote fat storage under hypercaloric pressure, inter-individual variability in hypothalamic PSA-NCAM might account for the vulnerability to diet-induced obesity. These data support the concept that reduced plasticity in brain circuits that control appetite, metabolism and body weight confers risk for eating disorders and obesity

Les céramiques du XIIe siècle de l'ensemble castral de l'ilot Saint Epoing à Nogent sur Seine dans leur contexte de production

International audienc

Présentation du projet de recherche sur la céramique aux Antilles et au Canada. Des confins occidentaux de la France aux Iles d’Amériques : vaisselle de table, de cuisine et de conservation importées du XVIe au XIXe siècle

International audienc

Les céramiques de raffinage du sucre en France et dans les colonies d’Amérique, XVIe – 1re moitié du XIXe siècle

International audienc

Role of the basolateral amygdala in retrieval of conditioned flavors in the awake rat

International audienceLearned association between odor, taste and further post-ingestive consequence is known as flavor nutrient conditioned preference. Amygdala is supposed to be one of the areas involved in these associations. In the present study, one flavor was associated with a 16% glucose (CS+) whereas another flavor was paired with less reinforcing 4% glucose (CS-). We showed that CS+ presentation after conditioning increased Fos expression in the basolateral nucleus of amygdala (BLA). Furthermore, we performed electrophysiological recordings in the BLA in free moving rats. After preference acquisition, rats were exposed to either the CS+ or the CS-. The proportion of neurons showing a decreased activity during the CS- presentation was significantly higher in conditioned rats compared to controls. Among this neuronal population recorded in conditioned rats, we noticed a significant proportion of neurons that also showed a decreased activity during the CS+ presentation. Our data indicate an involvement of BLA during retrieval of learned flavors. It also suggests that both flavors might have acquired a biological value through conditioning

Autocatalytic electroless nickel-boron platin of light alloys

peer reviewe

L’activité sucrière en Charentes du XVIe au XIXe s. Une synthèse des données archéologiques et archivistiques

International audienc