Refinement and growth enhancement of Al2Cu phase during magnetic field assisting directional solidification of hypereutectic Al-Cu alloy.

International audienceUnderstanding how the magnetic fields affect the formation of reinforced phase during solidification is crucial to tailor the structure and therefor the performance of metal matrix in situ composites. In this study, a hypereutectic Al-40 wt.% Cu alloy has been directionally solidified under various axial magnetic fields and the morphology of Al2Cu phase was quantified in 3D by means of high resolution synchrotron X-ray tomography. With rising magnetic fields, both increase of Al2Cu phase's total volume and decrease of each column's transverse section area were found. These results respectively indicate the growth enhancement and refinement of the primary Al2Cu phase in the magnetic field assisting directional solidification. The thermoelectric magnetic forces (TEMF) causing torque and dislocation multiplication in the faceted primary phases were thought dedicate to respectively the refinement and growth enhancement. To verify this, a real structure based 3D simulation of TEMF in Al2Cu column was carried out, and the dislocations in the Al2Cu phase obtained without and with a 10T high magnetic field were analysed by the transmission electron microscope

Intermittent High Glucose Enhances Apoptosis in INS-1 Cells

To investigate the effect of intermittent high glucose (IHG) and sustained high glucose (SHG) on inducing β-cell apoptosis and the potential involved mechanisms, INS-1 beta cells were incubated for 72 h in the medium containing different glucose concentrations: control (5.5 mmol/L), SHG (33.3 mmol/L), and IHG (5.5 mmol/L and 33.3 mmol/L glucose alternating every 12 h). Cell viability, apoptosis rate, and oxidative-stress markers were determined. The results showed that the apoptosis induced by IHG was more obvious than that by SHG. Simultaneously, the intracellular level of oxidative stress was more significantly increased in INS-1 cells exposed to IHG. These findings suggest that intermittent high glucose could be more deleterious to β-cell than a constant high concentration of glucose, this may be due to the aggravation of oxidative stress triggered by intermittent high glucose

Kaya: A Testing Framework for Blockchain-based Decentralized Applications

In recent years, many decentralized applications based on blockchain (DApp) have been developed. However, due to inadequate testing, DApps are easily exposed to serious vulnerabilities. We find three main challenges for DApp testing, i.e., the inherent complexity of DApp, inconvenient pre-state setting, and not-so-readable logs. In this paper, we propose a testing framework named Kaya to bridge these gaps. Kaya has three main functions. Firstly, Kaya proposes DApp behavior description language (DBDL) to make writing test cases easier. Test cases written in DBDL can also be automatically executed by Kaya. Secondly, Kaya supports a flexible and convenient way for test engineers to set the blockchain pre-states easily. Thirdly, Kaya transforms incomprehensible addresses into readable variables for easy comprehension. With these functions, Kaya can help test engineers test DApps more easily. Besides, to fit the various application environments, we provide two ways for test engineers to use Kaya, i.e., UI and command-line. Our experimental case demonstrates the potential of Kaya in helping test engineers to test DApps more easily

catena-Poly[[aqua­trimethyl­tin(IV)]-{[trimethyl­tin(IV)]-μ3-thio­phene-2,5-dicarboxyl­ato}]

In the title compound, [Sn2(CH3)6(C6H2O4S)(H2O)]n, each of the two crystallographically independent Sn atoms exhibits a distorted trigonal–bipyramidal coordination geometry formed by two O and three C atoms. The coordinated water mol­ecule plays an important role in crystal packing consolidation via O—H⋯O hydrogen bonding

IMP3 signatures of fallopian tube: a risk for pelvic serous cancers

BACKGROUND:Recent advances suggest fallopian tube as the main cellular source for women's pelvic serous carcinoma (PSC). In addition to TP53 mutations, many other genetic changes are involved in pelvic serous carcinogenesis. IMP3 is an oncofetal protein which has recently been observed to be overexpressed in benign-looking tubal epithelia. Such findings prompted us to examine the relationship between IMP3 over-expression, patient age and the likelihood of development of PSC.METHODS:Fallopian tubes from three groups (low-risk, high-risk, and PSC) of patients with matched ages were studied. Age was recorded in 10years intervals ranging from age 20 to older than 80. The number of IMP3 signatures (defined by 10 or more tubal secretory cells stained positively and continuously in benign appearing tubal mucosa) from both tubal fimbria and ampulla segments was measured. The data was analyzed by standard contingency table and Poisson distribution methods after age adjustment. IMP3 overexpression was also examined in serous tubal intraepithelial carcinoma and PSC.RESULTS:The positive IMP3-stained cells are mainly tubal secretory cells. The absolute number of tubal IMP3 signatures increased significantly within each age group. Age remained a significant risk factor for serous neoplasia after age adjustment. IMP3 signatures were more frequent in the patients of both high-risk and PSC groups. The presence of IMP3 signatures in tubal mucosa was significantly associated with tubal or pelvic serous carcinogenesis (p<0.001).CONCLUSIONS:The findings suggest that tubal secretory cells with IMP3 signatures showing growth advantage could potentially serve as a latent precancer biomarker for tubal or pelvic serous carcinomas in women.This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at [email protected]