1,378 research outputs found
Thoracic Disease Identification and Localization with Limited Supervision
Accurate identification and localization of abnormalities from radiology
images play an integral part in clinical diagnosis and treatment planning.
Building a highly accurate prediction model for these tasks usually requires a
large number of images manually annotated with labels and finding sites of
abnormalities. In reality, however, such annotated data are expensive to
acquire, especially the ones with location annotations. We need methods that
can work well with only a small amount of location annotations. To address this
challenge, we present a unified approach that simultaneously performs disease
identification and localization through the same underlying model for all
images. We demonstrate that our approach can effectively leverage both class
information as well as limited location annotation, and significantly
outperforms the comparative reference baseline in both classification and
localization tasks.Comment: Conference on Computer Vision and Pattern Recognition 2018 (CVPR
2018). V1: CVPR submission; V2: +supplementary; V3: CVPR camera-ready; V4:
correction, update reference baseline results according to their latest post;
V5: minor correction; V6: Identification results using NIH data splits and
various image model
Noncollinearity-modulated electronic properties of the monolayer CrI
Introducing noncollinear magnetization into a monolayer CrI is proposed
to be an effective approach to modulate the local electronic properties of the
two-dimensional (2D) magnetic material. Using first-principles calculation, we
illustrate that both the conduction and valence bands in the monolayer CrI
are lowered down by spin spiral states. The distinct electronic structure of
the monolayer noncollinear CrI can be applied in nanoscale functional
devices. As a proof of concept, we show that a magnetic domain wall can form a
one-dimensional conducting channel in the 2D semiconductor via proper gating.
Other possible applications such as electron-hole separation and identical
quantum dots are also discussed
Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for the treatment of multiple autoimmune diseases (1). In this study, we investigated the therapeutic effects and molecule mechanism of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment significantly alleviated clinical development in the myelin oligodendrocyte glycoprotein (MOG35–55) peptide-induced EAE model, markedly decreased inflammatory cell infiltration into the central nervous system and reduced demyelination. Further, carnosol inhibited Th17 cell differentiation and signal transducer and activator of transcription 3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia. Taken together, our results show that carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as MS
- …