Latin Etymologies as Features on BNC Text Categorization

PACLIC 23 / City University of Hong Kong / 3-5 December 200

Raman piezospectroscopic evaluation of intergrowth ferroelectric polycrystalline ceramic in biaxial bending configuration

The piezospectroscopic (PS) effect was studied in an intergrowth bismuth layer-structure ferroelectricceramicBi₅TiNbWO₁₅ according to a micro-Raman spectroscopic evaluation. By using a ball-on-ring flexure configuration, a biaxial stress was generated in a Bi₅TiNbWO₁₅ plate-like specimen and in situ collected Raman spectra were acquired and analyzed under several loading conditions. As the observed spectral line contained signals arising from the whole illuminated in-depth region, the laser probe information was deconvoluted (by means of an in-depth probe response function obtained according to the defocusing method) in order to deduce biaxial PS coefficients for the three Raman bands of Bi₅TiNbWO₁₅ located at 763, 857, and 886 cm−1, respectively. The biaxial PS coefficients of these bands were derived to be −1.74±0.16, −2.51±0.16, and −2.64±0.31 cm⁻¹/GPa, respectively, and should be referred to the c axis of the Bi5TiNbWO15 crystal

Spectrally resolved microprobe cathodoluminescence of intergrowth Bi₅ˍₓLaₓTiNbWO₁₅ ferroelectrics

Spectrally resolved cathodoluminescence measurements of Bi₅ˍₓLaₓTiNbWO₁₅(x=0–1.50) ceramics at room temperature showed three distinct luminescence bands located at about 380, 502, and 660nm, respectively, which were tentatively assigned to F+ center, oxygen vacancy-related defect and octahedron structure-related luminescence center, respectively. These assignments could be made in light of electron irradiation experiments with different exposure times. Bands related to oxygen vacancies were clearly enhanced by lanthanum doping, indicating that charge compensation occurred by the substitution of Bi for La3+ in perovskitelike structured intergrowth ferroelectrics. We observed that, for contents of La³⁺ x>0.75, La³⁺ ions entered the [Bi₂O₂]²⁺ layer according to a doping mechanism which is briefly discussed in this letter.This work was supported by the Ministry of Sciences and Technology of China through 973-project 2002CB613307 and National Natural Science Foundation of China NSFC No. 50572113

Augmenting Sign Language Exposure for Hearing Parent-Deaf Child Interaction

Above 90% of deaf children are born to hearing parents who are often non-fluent with sign language. The developmental consequences of early language deprivation experienced by deaf children can be witnessed in their later life outcomes. A significant portion of the deaf population are prone to cognitive delays, poor educational experiences, diminished career opportunities, and psychosocial difficulties (Hall 2017, 961). Given this, it becomes imperative to improve early childhood language experiences. To foster neuropsychological growth, language must be accessible to the child; in the case of deaf children, this would mean early exposure to a visual language..

Construction and characterization of infectious hepatitis C virus chimera containing structural proteins directly from genotype 1b clinical isolates

AbstractHCV genotype is a major determinant of clinical outcome, and GT1b HCV infection is the most difficult to treat and also the predominant genotype in East Asia and Europe. We developed 1b/JFH-1 inter-genotypic recombinants containing the structural genes (Core, E1, E2), p7 and the 1stTMD of NS2 directly from GT1b clinical isolates. Through a cloning selection strategy, we obtained 4 functional clones from 3 cases of GT1b patients' sera, which could produce infectious viruses in Huh7.5.1 cells. Sequencing analysis of recovered viruses from serial passage and reverse genetics revealed that adaptive mutations in the GT1b-originated region were enough for the enhancement of infectivity. A monoclonal antibody to E2 and original patient sera could efficiently block 3 of the viruses (26C3mt, 52B6mt and 79L9) while had little effect on 26C6mt viruses. The availability of 1b/JFH-1 chimeric viruses will be important for studies of isolate-specific neutralization and useful in evaluating antiviral therapies

Discussion on the mechanism of Danggui Sini decoction in treating diabetic foot based on network pharmacology and molecular docking and verification of the curative effect by meta-analysis

ObjectiveThe main active components and mechanism of Danggui Sini decoction (DSD) in treating diabetic foot (DF) were studied and verified by network pharmacology and molecular docking. Evidence-based medicine was used to prove its efficacy.MethodsThe TCMSP systematic pharmacology platform screened out DSD’s practical components and targets—screening disease targets in GeneCards database, using Cytoscape 3.7.2 to draw DSD–active ingredient–target network diagram, and drawing the protein interaction network diagram through STRING database. The Metascape platform was used to analyze the GO function enrichment and KEGG signal pathway. The molecular docking experiment was carried out by using Auto Dock vina 4.2. The related literature on DSD in treating DF in China Zhiwang, Wanfang, Weipu, and China Biomedical Literature Database was searched. The literature was screened, data was extracted, and quality was evaluated according to the inclusion and exclusion criteria. Then, a meta-analysis was performed using RevMan 5.3 software.ResultsA total of 256 targets of all effective components of DSD were obtained. Among 1,272 disease targets, there are 113 common targets. The GO analysis received 6,179 entries, and the KEGG pathway enrichment analysis found 251 related pathways. The molecular docking results of the main targets of diabetic foot and the active substances of DSD all showed a high docking activity. The meta-analysis included six literature, all of which were randomized controlled experiments. The quality grade of the literature was C, and the results showed that the total effective rate of clinical efficacy in the experimental group was significantly higher than that in the control group.ConclusionsDSD may treat DF by participating in biological processes such as cell proliferation regulation, inflammatory reaction, oxidative stress reaction, and promotion of angiogenesis. DSD treats DF through AKT1, TP53, IL6, TNF, VEGFA, and other targets. DSD plays a role in treating DF mainly through the AGE-RAGE signaling pathway and PI3K-AKT signaling pathway. The molecular docking results of AKT1, TP53, IL-6, TNF, and VEGFA with the active substances of DSD show that they all have a high docking activity; among them, VEGFA has a higher docking activity. Compared with conventional treatment, DSD has a high effective rate, short wound healing time, large wound healing area, and high ABI index

Acupuncture for Pain Management in Cancer: A Systematic Review and Meta-Analysis

Objective. To evaluate the effectiveness and safety of acupuncture for cancer-related pain. Methods. A systematic review of literatures published from database inception to February 2015 was conducted in eight databases. RCTs involving acupuncture for treatment of cancer-related pain were identified. Two researchers independently performed article selection, data extraction, and quality assessment of data. Results. 1,639 participants in twenty RCTs were analyzed. All selected RCTs were associated with high risk of bias. Meta-analysis indicated that acupuncture alone did not have superior pain-relieving effects as compared with conventional drug therapy. However, as compared with the drug therapy alone, acupuncture plus drug therapy resulted in increased pain remission rate, shorter onset time of pain relief, longer pain-free duration, and better quality of life without serious adverse effects. However, GRADE analysis revealed that the quality of all outcomes about acupuncture plus drug therapy was very low. Conclusions. Acupuncture plus drug therapy is more effective than conventional drug therapy alone for cancer-related pain. However, multicenter high-quality RCTs with larger sample sizes are needed to provide stronger evidence for the effectiveness of acupuncture in cancerrelated pain due to the low data quality of the studies included in the current meta-analysis