Ownership structure and new product development in transnational corporations in China

This paper examines the relationship between the ownership structure and new product development (NPD) at the affiliates of transnational corporations in China. Seven research hypotheses are tested on a panel data set covering 10,000 manufacturing firms with foreign involvement for the period 1998-2001. The results from probit and tobit models show that contractual joint ventures, equity joint ventures and joint stock enterprises are better organizational forms than wholly owned enterprises for increasing both the probability and intensity of NPD. We also find that ventures with OECD participation are more likely to be involved in NPD than those with participation by “overseas” Chinese TNCs

Distinct biological effects of different nanoparticles commonly used in cosmetics and medicine coatings

<p>Abstract</p> <p>Background</p> <p>Metal oxides in nanoparticle form such as zinc oxide and titanium dioxide now appear on the ingredient lists of household products as common and diverse as cosmetics, sunscreens, toothpaste, and medicine. Previous studies of zinc oxide and titanium dioxide in non-nanoparticle format using animals have found few adverse effects. This has led the FDA to classify zinc oxide as GRAS (generally recognized as safe) for use as a food additive. However, there is no regulation specific for the use of these chemicals in nanoparticle format. Recent studies, however, have begun to raise concerns over the pervasive use of these compounds in nanoparticle forms. Unfortunately, there is a lack of easily-adaptable screening methods that would allow for the detection of their biological effects.</p> <p>Results</p> <p>We adapted two image-based assays, a fluorescence resonance energy transfer-based caspase activation assay and a green fluorescent protein coupled-LC3 assay, to test for the biological effects of different nanoparticles in a high-throughput format. We show that zinc oxide nanoparticles are cytotoxic. We also show that titanium dioxide nanoparticles are highly effective in inducing autophagy, a cellular disposal mechanism that is often activated when the cell is under stress.</p> <p>Conclusion</p> <p>We suggest that these image-based assays provide a method of screening for the biological effects of similar compounds that is both efficient and sensitive as well as do not involve the use of animals.</p

LIO-PPF: Fast LiDAR-Inertial Odometry via Incremental Plane Pre-Fitting and Skeleton Tracking

As a crucial infrastructure of intelligent mobile robots, LiDAR-Inertial odometry (LIO) provides the basic capability of state estimation by tracking LiDAR scans. The high-accuracy tracking generally involves the kNN search, which is used with minimizing the point-to-plane distance. The cost for this, however, is maintaining a large local map and performing kNN plane fit for each point. In this work, we reduce both time and space complexity of LIO by saving these unnecessary costs. Technically, we design a plane pre-fitting (PPF) pipeline to track the basic skeleton of the 3D scene. In PPF, planes are not fitted individually for each scan, let alone for each point, but are updated incrementally as the scene 'flows'. Unlike kNN, the PPF is more robust to noisy and non-strict planes with our iterative Principal Component Analyse (iPCA) refinement. Moreover, a simple yet effective sandwich layer is introduced to eliminate false point-to-plane matches. Our method was extensively tested on a total number of 22 sequences across 5 open datasets, and evaluated in 3 existing state-of-the-art LIO systems. By contrast, LIO-PPF can consume only 36% of the original local map size to achieve up to 4x faster residual computing and 1.92x overall FPS, while maintaining the same level of accuracy. We fully open source our implementation at https://github.com/xingyuuchen/LIO-PPF.Comment: IROS 202

Mutations in hepatitis C virus E2 located outside the CD81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity.

Broadly neutralizing antibodies are commonly present in the sera of patients with chronic hepatitis C virus (HCV) infection. To elucidate possible mechanisms of virus escape from these antibodies, retrovirus particles pseudotyped with HCV glycoproteins (HCVpp) isolated from sequential samples collected over a 26-year period from a chronically infected patient, H, were used to characterize the neutralization potential and binding affinity of a panel of anti-HCV E2 human monoclonal antibodies (HMAbs). Moreover, AP33, a neutralizing murine monoclonal antibody (MAb) to a linear epitope in E2, was also tested against selected variants. The HMAbs used were previously shown to broadly neutralize HCV and to recognize a cluster of highly immunogenic overlapping epitopes, designated domain B, containing residues that are also critical for binding of viral E2 glycoprotein to CD81, a receptor essential for virus entry. Escape variants were observed at different time points with some of the HMAbs. Other HMAbs neutralized all variants except for the isolate 02.E10, obtained in 2002, which was also resistant to MAb AP33. The 02.E10 HCVpp that have reduced binding affinities for all antibodies and for CD81 also showed reduced infectivity. Comparison of the 02.E10 nucleotide sequence with that of the strain H-derived consensus variant, H77c, revealed the former to have two mutations in E2, S501N and V506A, located outside the known CD81 binding sites. Substitution A506V in 02.E10 HCVpp restored binding to CD81, but its antibody neutralization sensitivity was only partially restored. Double substitutions comprising N501S and A506V synergistically restored 02.E10 HCVpp infectivity. Other mutations that are not part of the antibody binding epitope in the context of N501S and A506V were able to completely restore neutralization sensitivity. These findings showed that some nonlinear overlapping epitopes are more essential than others for viral fitness and consequently are more invariant during earlier years of chronic infection. Further, the ability of the 02.E10 consensus variant to escape neutralization by the tested antibodies could be a new mechanism of virus escape from immune containment. Mutations that are outside receptor binding sites resulted in structural changes leading to complete escape from domain B neutralizing antibodies, while simultaneously compromising viral fitness by reducing binding to CD81

Experimental Quantum Cloning with Prior Partial Information

When prior partial information about a state to be cloned is available, it can be cloned with a fidelity higher than that of universal quantum cloning. We experimentally verify this intriguing relationship between the cloning fidelity and the prior information by reporting the first experimental optimal quantum state-dependent cloning, using nuclear magnetic resonance techniques. Our experiments may further have important implications into many quantum information processing protocols.Comment: 4 pages, 2 figure