In Search of Harmony Under Fast-Changing And Uncertain Environment:

Abstract: In front of more and more uncertain and fast-changing environment, modern management science with ground roots on Western reductionism philosophy is tending to be not applicable in many cases. Through the lens of holistic perspective from Chinese philosophical intelligence, the Confucian concept of harmony was introduced and compared with the Chinese pronunciation of harmony, He-Xie to help find the way to effective organizational management. The proposed He-Xie Management Theory (HXM) contains constructivism and evolutionary perspectives, adopting “design and optimizing” and “inducement evolution” mechanisms respectively, provides a pragmatic methodology and tool kits to both scholars and practitioners for cope with fast-changing and complex uncertain world by integrating traditional Chinese philosophical intelligence and modern scientific knowledge and techniques on problem-solving. This indigenous approach is supposed to offer a holistic intelligence towards bridging the current gap between micro and macro domains in management field. Key words: harmony; uncertainty; complexity; He-Xie Management Theor

Regulatory Mechanism and Application of lncRNAs in Poultry

Long noncoding RNA (lncRNAs) are transcripts greater than 200 nt in length with decreased coding potential and are widespread in all types of biological organisms. lncRNAs can interact with protein, DNA and RNA, respectively, which may participate in the multilevel regulation of transcriptional, post-transcriptional and epigenetic modifications. It is well known that lncRNA, which length is single-stranded non-coding RNA molecule, plays crucial roles in animal growth, development, cell proliferation and differentiation, and other life activities. In this research, we review the regulation mechanism and current research status of lncRNAs in chicken economic traits and disease, which would contribute to further understanding the regulatory mechanisms and application of lncRNAs in poultry

Interspecific and Intersexual Differences in the Chemical Composition of Floral Scent in Glochidion

Plants of the Glochidion (Phyllanthaceae) genus are pollinated exclusively by host-specific Epicephala (Gracillariidae) moths. Floral scent has been thought to play key role in the obligate pollination mutualism between Glochidion plants and Epicephala moths, but few studies have been reported about chemical variation in floral volatiles of Glochidion species in China. Floral volatiles of male and female flowers of five Glochidion species in south China were collected by dynamic headspace absorption technique and then were chemically analyzed by using gas chromatography-mass spectrometry. A total of 69 compounds were identified from floral scents of five investigated species. Glochidion hirsutum and G. zeylanicum showed no qualitative differences in floral scent, whereas there were clear variations of floral scent among other species (G. eriocarpum, G. daltonii, and G. sphaerogynum) and also they distinctly differed from these two species. Male flowers emitted significantly more scent than female flowers. Glochidion plants exhibited qualitative and quantitative differences in floral scent between two sexes of flowers. The findings suggest that the volatile variation of floral scent among Glochidion species reflects adaptations to specific pollinators. Sexual dimorphism in floral scent has evolved to signal alternative rewards provided by each sex to Epicephala moths

Financing Sources, R&D Investment and Enterprise Risk

AbstractResearch and development (R&D) investment of high-tech enterprises has an impact on enterprise risk, but the effect is different when funding sources are different. This paper aims to study the relationships among financing sources, R&D investment and enterprise risk. The empirical results suggest that the relationship between endogenous financing rate and R&D investment is significantly positive, and asset-liability ratio has a significantly negative impact on R&D investment. Furthermore, the study shows that relationship between enterprise risk and R&D investment can be described with a quadratic parabola

Detection and Utility of Genetic Variation in Chinese Local Chicken Breeds

China has a wide variety of indigenous chicken breeds. Most of these local chicken varieties have valuable genetic features. These resources could provide valuable breeding material for the poultry industry in China and even for the rest of the world. Assessment of genetic differences of these important chicken genetic resources is an important prerequisite to establish efficient conservation and utilization. Up to now, several types of genetic variations have been identified across genomes, and the area of genetic variation in the chicken genome seems to be a rapidly growing research topic in China. These research data can also provide additional evidence for our understanding of chicken genome variation, developing molecular markers, and elucidating the association between genetic variations and phenotypes in the future. This chapter reviews the research progress of molecular genetic variation in Chinese native chicken breeds in recent years

Association of myocardial iron deficiency based on T2* CMR with the risk of mild left ventricular dysfunction in HIV-1-infected patients

ObjectivesThis study sought to noninvasively determine myocardial iron levels in HIV-1-infected patients using CMR and explore the association between T2* values and mild left ventricular systolic dysfunction (LVSD).MethodsThis prospective study was conducted from June 2019 to July 2021. HIV-1-infected adults and healthy controls were consecutively enrolled for CMR exam. CMR exam included the assessment of myocardium iron content (T2*), cardiac function (cine), inflammation (T2), and fibrosis (through extracellular volume fraction [ECV] and late gadolinium enhancement [LGE]) measurements. Mild LVSD is defined as a left ventricular ejection fraction (LVEF) between 40% and 49%.ResultsOf 47 HIV-1-infected patients enrolled, 12 were diagnosed with mild LVSD (HIV-1+/LEVF+) and 35 were diagnosed with preserved LV function (HIV-1+/LEVF−). Compared with healthy controls, HIV-1-infected patients displayed higher T2*, T1, T2, ECV values and lower global circumferential strain (GCS) and global radial strain (GRS) (all P < 0.05). However, between patients with and without mild LVSD, only the T2* values and ECV (all P <0.05) were different. The association between increased T2* values (>26 ms) and mild LVSD remained significant after adjusting for the established univariate predictors (ECV >32.9%, T1 values >1336 ms) of mild LVSD (odds ratio [OR], 10.153; 95% confidence interval [CI] 1.565–65.878, P = 0.015).ConclusionsMyocardial T2* values were elevated in HIV-1-infected patients, supporting the notion that ID was associated with mild LVSD. Our findings highlight the potential for ID in HIV-1-infected patients as an auxiliary biomarker to monitor the course of LVSD

Competition of zinc ion for the [2Fe-2S] cluster binding site in the diabetes drug target protein mitoNEET

Human mitochondrial protein mitoNEET is a novel target of type II diabetes drug pioglitazone, and contains a redox active [2Fe-2S] cluster that is hosted by a unique ligand arrangement of three cysteine and one histidine residues. Here we report that zinc ion can compete for the [2Fe-2S] cluster binding site in human mitoNEET and potentially modulate the physiological function of mitoNEET. When recombinant mitoNEET is expressed in Escherichia coli cells grown in M9 minimal media, purified mitoNEET contains very little or no iron-sulfur clusters. Addition of exogenous iron or zinc ion in the media produces mitoNEET bound with a [2Fe-2S] cluster or zinc, respectively. Mutations of the amino acid residues that hosting the [2Fe-2S] cluster in mitoNEET diminish the zinc binding activity, indicating that zinc ion and the [2Fe-2S] cluster may share the same binding site in mitoNEET. Finally, excess zinc ion effectively inhibits the [2Fe-2S] cluster assembly in mitoNEET in E. coli cells, suggesting that zinc ion may impede the function of mitoNEET by blocking the [2Fe-2S] cluster assembly in the protein. Copyright © Springer Science+Business Media, LLC. 2012

mTOR Signaling in X/A‐Like Cells Contributes to Lipid Homeostasis in Mice

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147831/1/hep30229-sup-0001-FigS1-S8.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147831/2/hep30229_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147831/3/hep30229.pd