Aqua­(2,6-dihy­droxy­benzoato-κO 1)bis­(1,10-phenanthroline-κ2 N,N′)manganese(II) 2,6-dihy­droxy­benzoate hemihydrate

In the complex cation of the title compound, [Mn(C7H5O4)(C12H8N2)2(H2O)](C7H5O4)·0.5H2O, the MnII atom has a six-coordinate octa­hedral environment defined by one carboxyl­ate O atom belonging to a 2,6-dihy­droxy­benzoate (DHB) ligand, four N atoms from two chelating 1,10-phenanthroline mol­ecules and one water mol­ecule. The lattice water mol­ecule lies on a twofold rotation axis. Intra­molecular O—H⋯O hydrogen bonds are present in the DHB anions and complex cations. Inter­molecular O—H⋯O hydrogen bonds link two cations, two anions and one water mol­ecule into a dimer. π–π inter­actions between the pyridine and benzene rings and between the benzene rings are also observed [centroid–centroid distances = 3.7774 (16), 3.7912 (16) and 3.7310 (17) Å]

Research on vibration displacement test method for large-caliber artillery muzzle

In order to solve the problem of muzzle vibration displacement test of large caliber under high elevation, this paper presents a test method by two high-speed photography. The method fully considers the influence of the muzzle torsion on the measurement results, and accurately obtains the three-dimensional vibration displacement of the muzzle of the large caliber artillery. Finally, through the result analysis, the accuracy of the measurement results can reach 0.1 mm, which shows the advantage of the sub-pixel-based high-speed camera processing method in the muzzle vibration displacement test of the conventional artillery. This paper proposes an innovative test method that accurately measures the vibration displacement of the muzzle using a non-contact method

Diaqua­(2,6-dihy­droxy­benzoato-κ2 O 1 ,O 1′)bis­(2,6-dihy­droxy­benzoato-κO 1)bis­(1,10-phenanthroline-κ2 N,N′)lanthanum(III)–1,10-phenanthroline (1/1)

In the title compound, [La(C7H5O4)3(C12H8N2)3(H2O)2]·C12H8N2, the LaIII atom is coordinated by four N atoms from two chelating 1,10-phenanthroline (phen) ligands, four O atoms from three 2,6-dihy­droxy­benzoate (DHB) anions (one monodentate, the other bidentate) and two water O atoms, completing a distorted LaN4O6 bicapped square-anti­prismatic geometry. Within the mononuclear complex mol­ecule, intra­molecular π–π stacking inter­actions are observed, the first between a coordinated phen mol­ecule and a DHB ligand [centroid–centroid distance = 3.7291 (16) Å], and the second between a coordinated phen mol­ecule and an uncoordinated phen ligand [centroid–centroid distance = 3.933 (2) Å]. Inter­molecular π–π stacking is observed between adjacent complexes [inter­planar distance = 3.461 (3) Å]. Intra- and inter­molecular O—H⋯O hydrogen bonds are observed in the DHB ligands and between a water mol­ecule and DHB ligands, respectively. O—H⋯N hydrogen bonds are also observed in the DHB ligands and between uncoordinated phen mol­ecules and aqua ligands

Acupuncture for migraine: a protocol for a meta-analysis and meta-regression of randomised controlled trials

INTRODUCTION Although the effectiveness of acupuncture for episodic migraine has been confirmed by multiple clinical trials and Cochrane systematic reviews, the mechanisms underlying the specific effect of acupuncture for migraine remain controversial. We aim to evaluate the effectiveness and safety of acupuncture for both episodic migraine and chronic migraine by meta-analysis and explore the possible factors influencing the specific effect of acupuncture for migraine by meta-regression. METHODS AND ANALYSIS We will search for randomised control trials of acupuncture for migraine in the following eight databases: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, AMED (via OVID) and four Chinese databases (Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database and Wanfang Database) from inception to 31 December 2017. We will also search OpenSIGLE (opensigle.inist.fr) for conference abstracts. No language restriction will be applied. The selection of studies, data extraction and coding and assessment of risk of bias of the included studies will be conducted independently by two reviewers. Standard meta-analysis and, if appropriate, meta-regression will be performed using the R packages Meta and Metafor. ETHICS AND DISSEMINATION The results of this meta-analysis and meta-regression will be disseminated through publication in a peer-reviewed journal and presented at a relevant conference. The data used in this meta-analysis will not contain individual patient data; therefore, ethical approval is not required. PROSPERO REGISTRATION NUMBER CRD42018087270

Simulation and experimental investigation of high-speed projectile impacting closed-cell aluminum foam

In order to analyze the impact acceleration of the projectile impacting the aluminum foam material, a dynamic non-linear finite element model of the projectile impacting the closed-cell aluminum foam experiment device was established and verified by the experiment. It is found that the numerical simulation results of projectile impact closed-cell aluminum foam are consistent with the change of experimental results. When the projectile impacts the homogeneous closed-cell aluminum foam, the impact acceleration is trapezoidal and the impact peak and pulse width are related to the density of the aluminum foam material. With the increase of the porosity of the aluminum foam, the peak value of the acceleration rises and the pulse width of acceleration decreases

Activated NK cells kill hepatic stellate cells via p38/PI3K signaling in a TRAIL-involved degranulation manner

NK cells are important in regulating hepatic fibrosis via their cytotoxic killing of hepatic stellate cells (HSCs). NK cells are activated by both cytokines such as IL-12 and IL-18, and innate immune stimuli such as ligation of TLRs. The secretion of IL-18 depends upon activation of the inflammasome, whereas TLRs are stimulated by microbial products. In the case of NK cells, IL-18 acts synergistically with stimulation of TLR3 to cause cell activation and cytotoxic function. In the present study, we activated NK cells to kill HSCs via IL-18 and TLR3 ligand stimulation, and dissected the signaling pathways or molecules critical for such activation or killing. We find that such activation depends on signaling via the p38/PI3K/AKT pathway, and that the activatedNK cells mediate HSC death in a TRAIL-involved mechanism. As liver fibrosis is a major global health problem with no good solution, these results emphasize that the p38/PI3K/AKT pathway in NK cells may be a novel drug target to promote fibrosis regression

Photodynamic therapy with light-emitting diode arrays producing different light fields induces apoptosis and necrosis in gastrointestinal cancer

IntroductionLight-emitting diodes (LEDs) have become a new light source for photodynamic therapy (PDT) because of their excellent optical properties, small size, and low cost. LED arrays have so far been designed to meet the need for accurate illumination of irregular lesions. However, LED arrays determine not only the shape of the illuminated spot but also the light field, which has a significant impact on the efficacy of PDT.MethodsWe designed three types of LED arrays producing different light fields, namely an intensive LED array for a uniform light field, a sparse LED array for a non-uniform light field, and a point LED array for a Gaussian-like light field, and investigated the effect and mechanism of these light fields on PDT for gastrointestinal cancer both in vitro and in vivo.ResultsWe found that intensive LED-PDT induced earlier and more serious cell death, including apoptosis and necrosis, than sparse LED-PDT and point LED-PDT. Among the three LED arrays, the intensive LED array induced cells to produce more differential proteins (DEPs), mainly related to mitochondria, ribosomes, and nucleic acids. DEPs in cells subjected to sparse LED- and point LED-PDT were mainly involved in extracellular activities. For MGC-803 tumor-bearing mice, intensive LED-PDT and point LED-PDT had better tumor ablation effect than sparse LED-PDT. Notably, recurrence was observed on day 7 after sparse LED-PDT. VCAM-1 and ICAM-1 were highly expressed in sparse LEDs-PDT treated tumor tissues and were associated tumor angiogenesis, which in turn lead to poor tumor suppression.ConclusionsTherefore, the type of LED array significantly affected the performance of PDT for gastrointestinal cancer. Uniform light field with low power densities work better than non-uniform and Gaussian-like light fields